Epigenetics in Endocrine-Related Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: 25 December 2025 | Viewed by 255
Special Issue Editor
Interests: breast cancer; ovarian cancer; castration resistance prostate cancer (CRPC); histone methylation; transcriptional regulation; treatment resistance
Special Issue Information
Dear Colleagues,
Endocrine-related cancers are a group of solid tumors that arise within endocrine glands such as thyroid, ovary and prostate. Current treatments target hormones that support tumor growth, but hormone-targeted therapies often lead to endocrine resistance and aggressive tumors. Treatment resistance and identification of new therapeutic avenues are critical for offering cancer patients a longer life and better quality of life.
As an emerging hallmark of cancer, epigenetic alterations have been shown to play a role in cancer progression and treatment resistance. As epigenetic changes alter genomic stability, transcriptional regulation and splicing, understanding the epigenetic landscape within primary tumors and during endocrine resistance will also identify vulnerabilities that can be therapeutically targeted. Unlike hematological cancers, treating solid tumors with epigenetic inhibitors has been challenging. But with pharmacological inhibitors of epigenetic modifiers being used in the clinic (DNMT and BET inhibitors), the development of the next generation of ‘Epi-drugs’ and promise of targeting RNA moieties, can the use of ‘Epi-drugs’ in combination with current treatments increase treatment efficacy in solid tumors?
This Special Issue on ‘Epigenetics in Endocrine-Related Cancer’ aims to highlight how changes in epigenetic marks can be utilized as biomarkers for patient stratification, further understanding the role epigenetics plays in treatment resistance in endocrine-related cancers and identifying epigenetic modifiers as novel therapeutic targets, all towards utilizing the epigenetic landscape in precision medicine.
Dr. Jennie N Jeyapalan
Guest Editor
Manuscript Submission Information
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Keywords
- breast
- ovarian
- CRPC (castration-resistant prostate cancer)
- thyroid
- histone modification
- DNA methylation
- epigenomics, chromatin
- microRNAs
- lncRNAs
- epi-drugs
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