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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biliary Tract Cancer: Challenges and Strategies in Centralizing Care for Rare Tumors
edited by Angela Lamarca
submission deadline 31 Dec 2026 | Viewed by 209 | Submission Open
Keywords: biliary tract cancer; centralization of care; recommendations
Blood–Brain Barrier and Brain Metastases
edited by Liliana Santos
submission deadline 31 Dec 2026 | Viewed by 200 | Submission Open
Keywords: brain metastasis; blood–brain barrier; tumour microenvironment; cancer immunology; drug delivery; metastatic niche; targeted therapy
(This special issue belongs to the Section Cancer Metastasis)
Advances in Multimodal Treatment for Locally Advanced Head and Neck Cancer: Neoadjuvant Therapy, Surgery, and Radiotherapy De-Escalation
edited by and Hongli Gong
submission deadline 31 Dec 2026 | Viewed by 193 | Submission Open
Keywords: head and neck cancer; neoadjuvant therapy; immunotherapy; organ preservation; radiotherapy de‑escalation; predictive biomarkers; prognosis
(This special issue belongs to the Section Cancer Therapy)
Chronic Lymphocytic Leukemia and Indolent B-Cell Lymphomas: Clonal Evolution, Microenvironment, and Immune Remodeling
edited by Franco Fais
submission deadline 31 Dec 2026 | Viewed by 192 | Submission Open
Keywords: chronic lymphocytic leukemia; indolent B-cell lymphomas; clonal evolution; tumor microenvironment; lymph node and bone marrow niche; B-cell receptor signaling; immune dysfunction; T-cell exhaustion; therapy resistance; intratumoral heterogeneity; metabolic reprogramming
Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management (2nd Edition) submission deadline 31 Dec 2026 | Viewed by 187 | Submission Open
Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms
Surgical Oncology for Hepato-Pancreato-Biliary Cancer: 2nd Edition
edited by Zaed Z. R. Hamady
submission deadline 31 Dec 2026 | Viewed by 167 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research in Cancer)
Genomics, Epigenomics and Targeted Therapy of Oral Squamous Cell Carcinoma
edited by Mustafa Ozen
submission deadline 31 Dec 2026 | Viewed by 164 | Submission Open
Keywords: oral squamous cell carcinoma; genomics; epigenomics; targeted therapy; biomarkers; tumor microenvironment; precision medicine; translational research
Non-Contrast Breast Cancer MRI Screening: Diffusion-Weighted Imaging, DWIBS, and Clinical Implementation
edited by
submission deadline 31 Dec 2026 | Viewed by 161 | Submission Open
Keywords: non-contrast breast MRI; breast cancer screening; diffusion-weighted imaging; DWIBS; dense breasts; cancer detection rate; positive predictive value; quality control; remote interpretation; screening implementation
Cancer Without Borders: International Perspectives on Prevention, Diagnosis and Treatment
edited by Km Monirul Islam
submission deadline 31 Dec 2026 | Viewed by 159 | Submission Open
Keywords: global oncology; cancer prevention; early detection; health disparities; cancer care delivery
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Inducement Factors, Precision Diagnostics, and Targeted Therapeutic Strategies for Basal Cell Carcinoma
edited by
submission deadline 31 Dec 2026 | Viewed by 153 | Submission Open
Keywords: basal cell carcinoma; inducement factors; precision diagnostics; molecular profiling; targeted therapy; hedgehog signaling pathway; biomarkers; non-invasive imaging; personalized medicine; diagnostic histopathology
Cellular Plasticity in Cancer Progression
edited by Deemesh Oudit
submission deadline 31 Dec 2026 | Viewed by 153 | Submission Open
Keywords: cellular plasticity; epithelial-mesenchymal transition (EMT); cancer stem cells (CSCs); phenotypic plasticity; cell state transitions; lineage plasticity; tumour heterogeneity; dedifferentiation; drug-tolerant persistent cells; epigenetic reprogramming; phenotypic switching; transdifferentiation; cancer cell stemness; tumour microenvironment (TME); therapy resistance (adaptive/reversible resistance); single-cell RNA sequencing
(This special issue belongs to the Section Cancer Pathophysiology)
Contemporary Pathology of Genitourinary Cancers
edited by Gang Wang and
submission deadline 31 Dec 2026 | Viewed by 139 | Submission Open
Keywords: pathology; genitourinary cancers; diagnostic; molecular; biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Carbon-Ion Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer
edited by
submission deadline 31 Dec 2026 | Viewed by 137 | Submission Open
Keywords: prostate cancer; carbon-ion radiotherapy; androgen deprivation therapy; biochemical relapse-free survival; overall survival; salvage treatment
(This special issue belongs to the Section Cancer Therapy)
Advancements in Molecular Research of Prostate Cancer (2nd Edition)
edited by
submission deadline 31 Dec 2026 | Viewed by 135 | Submission Open
Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Role of PET/CT Imaging in Cancer Diagnosis and Precision Oncology submission deadline 31 Dec 2026 | Viewed by 129 | Submission Open
Keywords: PET; cancer diagnosis; oncology; molecular imaging; radiopharmaceuticals; quantitative imaging; radiomics; artificial intelligence; theranostics; precision oncology
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Understanding Drug Resistance in Multiple Myeloma: Biomarkers, Sensitivity and Resistance in MM Cells
edited by Barry A. Paul
submission deadline 31 Dec 2026 | 1 articles | Viewed by 121 | Submission Open
Keywords: biomarkers; multiple myeloma; resistance
(This special issue belongs to the Section Cancer Drug Development)
Novel Targets and Emerging Therapies in T-Cell Lymphomas
edited by Huilai Zhang
submission deadline 31 Dec 2026 | Viewed by 114 | Submission Open
Keywords: T-cell lymphomas; targeted therapy; immunotherapy; epigenetic modulation; clinical trials
(This special issue belongs to the Section Cancer Therapy)
The Mediastinum—Pandora’s Box
edited by
submission deadline 1 Jan 2027 | 2 articles | Viewed by 7370 | Submission Open
Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors
Evolving Landscape in the Management of Liver Malignancies
edited by Ioannis A. Ziogas and
submission deadline 1 Jan 2027 | Viewed by 383 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; colorectal liver metastasis; liver resection; liver transplantation; transplant oncology; locoregional therapies; immunotherapy; molecular profiling
The Function of the MYC Network in Normal and Neoplastic Tissues
edited by and Dean W. Felsher
submission deadline 1 Jan 2027 | Viewed by 217 | Submission Open
Keywords: aging; cancer; enhancers; ribosomes; transcription; tumor metabolism; tumor suppressors; Warburg effect
(This special issue belongs to the Section Molecular Cancer Biology)
Nursing and Supportive Care for Cancer Survivors
edited by
submission deadline 2 Jan 2027 | 4 articles | Viewed by 7559 | Submission Open
Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Systematic Reviews and Meta-Analyses on Skin Cancer
edited by
submission deadline 5 Jan 2027 | Viewed by 296 | Submission Open
Keywords: skin cancer; dermatologic oncology; Mohs micrographic surgery; cutaneous oncology; systematic review
Nutrition in Cancer Care: From Generalized to Personalized Adjunctive Therapy submission deadline 6 Jan 2027 | 4 articles | Viewed by 3452 | Submission Open
Keywords: anthropometry; body mass index (BMI); body surface area (BSA); personalized medicine; therapeutic drug monitoring (TDM); pharmacokinetics; nutritional status; chemotherapy optimization; vitamin D; adjunctive therapy
The Advances in Proton Therapy in Head-and-Neck Cancers
edited by and Edward Christopher Dee
submission deadline 8 Jan 2027 | Viewed by 642 | Submission Open
Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities submission deadline 10 Jan 2027 | 1 articles | Viewed by 822 | Submission Open
Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor–stroma interaction; tumor–peritoneal interaction
(This special issue belongs to the Section Tumor Microenvironment)
Contemporary Advances in Esophageal and Upper Gastrointestinal Cancer Management
edited by and Carlo Castoro
submission deadline 10 Jan 2027 | Viewed by 168 | Submission Open
Keywords: esophageal surgery; gastric surgery; upper gastrointestinal cancer; minimally invasive surgery; robotic surgery; artificial intelligence; radiomics; neoadjuvant therapy; surgical quality assessment; fluorescence-guided surgery
(This special issue belongs to the Section Methods and Technologies Development)
Perioperative Management and Anesthetic Strategies for Improving Cancer Prognosis submission deadline 13 Jan 2027 | 1 articles | Viewed by 1145 | Submission Open
Keywords: perioperative care; anesthesia; cancer; oncological outcomes
Advances in Hodgkin Lymphoma (HL)
edited by
submission deadline 15 Jan 2027 | 4 articles | Viewed by 13862 | Submission Open
Keywords: classic Hodgkin lymphoma; diagnostic challenges; tumour microenvironment; variability in disease extent; TME-targeted therapies; personalized treatment; relapsed/refractory cHL
(This special issue belongs to the Section Cancer Pathophysiology)
Lung Cancer—Advances in Therapy and Prognostic Prediction
edited by Chinmay T. Jani and Estelamari Rodríguez
submission deadline 15 Jan 2027 | 7 articles | Viewed by 8258 | Submission Open
Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
Penile Cancer and Rare Urogenital Malignancies: From Biology to Clinical Management
edited by and Marcin Matuszewski
submission deadline 15 Jan 2027 | 4 articles | Viewed by 7832 | Submission Open
Keywords: penile cancer; urethral carcinoma; upper tract urothelial carcinoma; rare urogenital tumors; surgical management; systemic therapy; epidemiology
New Insights into Thymic Tumors
edited by Till Ploenes
submission deadline 15 Jan 2027 | 2 articles | Viewed by 2146 | Submission Open
Keywords: thymic tumors; thymic carcinoma; thymomas; new daignostic and therapeutic approaches; myasthenia gravis
Nanocarriers as an Emerging Platform for Cancer Therapy
edited by and Fernanda Ramos-Gomes
submission deadline 15 Jan 2027 | 2 articles | Viewed by 1920 | Submission Open
Keywords: nanoparticles; cancer therapy; nanomedicine; theranostics; chemotherapy; nanocarriers; drug delivery; nanotechnology
(This special issue belongs to the Section Cancer Therapy)
Flow Cytometry in Acute Leukemia: From Diagnosis to Disease Monitoring submission deadline 15 Jan 2027 | 2 articles | Viewed by 1718 | Submission Open
Keywords: acute leukemia; ALL; AML; flow cytometry; NGF; leukemia stem cells (LSCs; minimal residual disease (MRD)
(This special issue belongs to the Section Methods and Technologies Development)
Mass Spectrometry and Cancers submission deadline 15 Jan 2027 | 1 articles | Viewed by 1019 | Submission Open
Keywords: cancer; biomolecular; mass spectrometry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment submission deadline 15 Jan 2027 | Viewed by 912 | Submission Open
Keywords: CAR-T cell therapy; breast cancer; triple-negative breast cancer (TNBC); HER2-positive breast cancer; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers
edited by and George Wai Cheong Yip
submission deadline 15 Jan 2027 | Viewed by 489 | Submission Open
Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model
(This special issue belongs to the Section Methods and Technologies Development)
AI and Machine Learning in Cancer Multi-Omics: Identification of Biomarkers, Disease-Related Processes and Drug Targets
edited by Graham Ball
submission deadline 15 Jan 2027 | Viewed by 423 | Submission Open
Keywords: artificial intelligence; machine learning; multi-omics integration; biomarker discovery; precision oncology; drug target identification; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Pancreatic Cancer: Genomics, Therapy and Survival
edited by Hisanobu Ogata
submission deadline 15 Jan 2027 | Viewed by 372 | Submission Open
Keywords: pancreas; cancer; treatment; oncolytic virus; stromal cell; cancer-associated fibroblast (CAF)
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy in Gynecological Cancer: State of the Art (2nd Edition) submission deadline 15 Jan 2027 | Viewed by 264 | Submission Open
Keywords: interventional radiotherapy; brachytherapy techniques; gynecological oncology; educational gynecology; gynecological cancer
(This special issue belongs to the Section Cancer Therapy)
Improving the Quality of Life in Patients with Gynecological Cancer
edited by Vasilios Pergialiotis
submission deadline 20 Jan 2027 | 2 articles | Viewed by 14588 | Submission Open
Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention
edited by Adam Barsouk
submission deadline 20 Jan 2027 | 2 articles | Viewed by 4013 | Submission Open
Keywords: epidemiology; disparities; oncology; cancer; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Molecules and Drug Delivery Systems in Brain Tumors
edited by Horng-Jyh Harn and Ching-Ann Liu
submission deadline 27 Jan 2027 | Viewed by 102 | Submission Open
Keywords: brain tumors; blood–brain barrier; drug delivery systems; nanoparticles; molecular targets; targeted therapy; nanomedicine; combination therapy; translational research; biomarkers
(This special issue belongs to the Section Cancer Drug Development)
Advances in Clinical Therapy and Prognosis of Gastrointestinal Cancer
edited by Liliana Streba and Michael Schenker
submission deadline 30 Jan 2027 | 6 articles | Viewed by 9804 | Submission Open
Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations
(This special issue belongs to the Section Clinical Research in Cancer)
Genetic Determinism and Singularity: Fundamentals of Genomic, Predictive and Personalized Medicine of Thyroid Cancer
edited by Ginesa Maria Garcia-Rostan
submission deadline 30 Jan 2027 | Viewed by 182 | Submission Open
Keywords: screening; molecular pathogenesis; metastases; progression; dedifferentiation; prognostic biomarkers; targeted therapies; molecular heterogeneity and therapy resistance; follicular-cell-derived thyroid carcinomas; C-cell-derived thyroid carcinomas
Circulating Tumor DNA in Solid Tumors
edited by and Xiao Han
submission deadline 30 Jan 2027 | Viewed by 169 | Submission Open
Keywords: circulating tumor DNA; liquid biopsy; precision oncology
(This special issue belongs to the Section Cancer Biomarkers)
Lymphoma: From Pathology to Clinical Applications
edited by Eduardo M. Sotomayor and
submission deadline 30 Jan 2027 | Viewed by 96 | Submission Open
Keywords: lymphoma; next-generation sequencing; molecular subtypes; measurable residual disease; cellular therapy; precision medicine
New Perspectives in the Management of Breast Cancer submission deadline 31 Jan 2027 | 15 articles | Viewed by 48170 | Submission Open
Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials and Outcomes for Non-Small Cell Lung Cancer submission deadline 31 Jan 2027 | 8 articles | Viewed by 12813 | Submission Open
Keywords: non-small cell lung cancer; oncogenic alterations; clinical trial; systemic therapy; targeted therapy; immunotherapy; radiotherapy; real-world data; surgery; drug development
(This special issue belongs to the Section Clinical Research in Cancer)
The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine
edited by Aftab Alam
submission deadline 31 Jan 2027 | 5 articles | Viewed by 9947 | Submission Open
Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Liquid Biopsy Biomarkers of Cancer
edited by
submission deadline 31 Jan 2027 | 6 articles | Viewed by 9610 | Submission Open
Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; extracellular vesicles; circulating RNA; cfDNA methylation; fragmentome; reference material; miRNA; multi-cancer detection
(This special issue belongs to the Section Cancer Biomarkers)
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