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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Roles of Deep Learning in Cancer Radiotherapy

edited by Zhen Tian

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2666 | Submission Open

Keywords: radiotherapy; deep learning; artificial Intelligence; tumor detection; image segmentation; treatment planning; outcome prediction; radiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2158 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Diagnostic Biomarkers in Cancers Study

edited by Zejuan Li and

Xin Yi

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2015 | Submission Open

Keywords: cancer; diagnostics; biomarker

(This special issue belongs to the Section Cancer Biomarkers)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1293 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

Human Papillomavirus (HPV) and Related Cancer

edited by

Beata Biesaga

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1215 | Submission Open

Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in Pancreatoduodenectomy

edited by Chang Moo Kang and Jae Hoon Lee

submission deadline 31 Oct 2025 | 1 articles | Viewed by 993 | Submission Open

Keywords: surgical innovations and techniques in pancreatoduodenectomy; surgical anatomy to understand pancreatoduodenectomy; advances in preoperative imaging and planning; perioperative care and complications management; oncologic outcomes and long-term survival studies; multidisciplinary approaches to enhance patient outcomes; emerging technologies and their impact on surgical precision

(This special issue belongs to the Section Clinical Research of Cancer)

Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)

edited by

Eduardo Nagore

submission deadline 31 Oct 2025 | 1 articles | Viewed by 957 | Submission Open

Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant

(This special issue belongs to the Section Cancer Therapy)

Advances in the Clinical Management of Genitourinary Tumors

edited by

Felix Busch

and Markus Graf

submission deadline 31 Oct 2025 | 1 articles | Viewed by 799 | Submission Open

Keywords: urogenital neoplasms; prostatic neoplasms; kidney neoplasms; ureteral neoplasms; urethral neoplasms; testicular neoplasms; urinary bladder neoplasms; disease management; artificial intelligence; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Skin Cancer Diagnostics and Therapy: Research and Clinical Studies (2nd Edition)

edited by Cristel Ruini

submission deadline 31 Oct 2025 | 1 articles | Viewed by 619 | Submission Open

Keywords: non-melanoma skin cancer; melanoma; actinic keratosis; field cancerisation; medical diagnostics; dermatology; dermoscopy; optical coherence tomography; in vivo confocal microscopy; ex vivo confocal microscopy; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Advances in Targets for CAR T Therapy in Hematologic Malignancies

edited by

Ugo Testa

submission deadline 31 Oct 2025 | 1 articles | Viewed by 608 | Submission Open

Keywords: cancer immunotherapy; chimeric antigen receptor T-cell (CAR-T); leukemia; lymphoma; myeloma

(This special issue belongs to the Section Cancer Therapy)

Chemoprevention Advances in Cancer (2nd Edition)

edited by

Komal Raina

submission deadline 31 Oct 2025 | 1 articles | Viewed by 530 | Submission Open

Keywords: cancer prevention; chemoprevention; nutrition and cancer; bio-active food components; natural products; non-toxic anticancer agents; precision nutrition in cancer; tumor metabolomics; gut microbiome in cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancer Screening and Primary Care

edited by Marievelisse Soto-Salgado

submission deadline 31 Oct 2025 | Viewed by 367 | Submission Open

Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)

edited by

Emad H. Kandil

submission deadline 31 Oct 2025 | 1 articles | Viewed by 340 | Submission Open

Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries

(This special issue belongs to the Section Methods and Technologies Development)

MicroRNA (miRNA) in Cancers

edited by

Jochen Maurer

and Elmar Stickeler

submission deadline 31 Oct 2025 | Viewed by 338 | Submission Open

Keywords: miRNAs; cancer; diagnostics; tumor progression; metastasis; therapeutic targets; personalized medicine; pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Inhibitory Receptors and Related Cancer Immunotherapy

edited by Keqiang Chen, Feng Zhu and Xin Li

submission deadline 31 Oct 2025 | Viewed by 232 | Submission Open

Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Role of Nutrients in Cancer Progression

edited by

Ikuko Kato

submission deadline 31 Oct 2025 | Viewed by 225 | Submission Open

Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Heme Metabolism in Oncogenesis and Tumor Microenvironment: Mechanisms and Emerging Therapeutic Strategies

edited by Rays H.Y. Jiang and Gloria C. Ferreira

submission deadline 31 Oct 2025 | Viewed by 202 | Submission Open

Keywords: heme metabolism; oncogenesis; tumor microenvironment; porphyrin biosynthesis; redox homeostasis; cancer metabolism; heme biosynthesis pathways; CRISPR screening; iron metabolism; therapeutic targeting of heme pathways

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetic Regulators and Cancer Precision Therapies

edited by Biaoru Li

submission deadline 31 Oct 2025 | Viewed by 199 | Submission Open

Keywords: tumorigenesis; epigenetics; epigenomics; personalized therapy

(This special issue belongs to the Section Cancer Therapy)

Lung Cancer: Updates on Therapy and Prognostic Prediction

edited by Servet Bölükbas

submission deadline 31 Oct 2025 | Viewed by 198 | Submission Open

Keywords: lung cancer; targeted therapy; immunotherapy; prognostic prediction; precision medicine; biomarkers; artificial intelligence; next-generation sequencing; personalized treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Proton and Light Ion Therapy for Cancer

edited by Oliver Jäkel

submission deadline 31 Oct 2025 | Viewed by 177 | Submission Open

Keywords: novel beam delivery concepts; image guidance; adaptive therapy; in vivo monitoring; radiobiological studies with protons and light ions; clinical studies; outcome reports

(This special issue belongs to the Section Cancer Therapy)

Recent Updates and Future Perspectives of Anti-Cancer Agents

edited by

Santosh Kumar Singh

submission deadline 31 Oct 2025 | Viewed by 157 | Submission Open

Keywords: cancer; anti-cancer agents; targeted therapy; drug resistance; therapeutic agents; natural compounds; combination therapy; nanotherapy; translational therapy; immunotherapy

(This special issue belongs to the Section Cancer Drug Development)

Advances in Early Diagnosis and Minimally Invasive Management in Breast Cancer

edited by

Graziella Di Grezia

submission deadline 31 Oct 2025 | Viewed by 145 | Submission Open

Keywords: precision medicine; breast cancer prevention; cancer detection; early diagnosis; therapeutic strategies; artificial intelligence; image analysis; risk predictors

(This special issue belongs to the Section Methods and Technologies Development)

Pathology of Gynecological Cancers—Second Edition

edited by

Mohamed Desouki

submission deadline 31 Oct 2025 | Viewed by 137 | Submission Open

Keywords: endometrial cancer; ovarian cancer; vulvar cancer; cervical cancer; vaginal cancer

(This special issue belongs to the Section Cancer Pathophysiology)

The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment

edited by

Michael I. Koukourakis

and

Athanasia Mitsala

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Childhood Cancer in the Genomic Era: Experimental and Theoretical Approaches (2nd Edition)

edited by

George I. Lambrou

submission deadline 31 Oct 2025 | Viewed by 98 | Submission Open

Keywords: microarrays; NGS; mutation analysis; CNV; epigenetics; modeling; mathematical models; physical models

(This special issue belongs to the Section Molecular Cancer Biology)

Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 31 Oct 2025 | Viewed by 96 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

New Strategies for the Treatment of Melanoma and Non-Melanoma Skin Cancer

edited by

Yoshihide Asano

and

Taku Fujimura

submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; immunotherapy; anti-PD-1 antibody; BRAF/MEK inhibitors; racial differences; prognosis

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers

edited by Ting-Tai Yen and Eugene Patrick Toy

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Discoveries in Targeted Therapies for Melanoma: From Molecular Mechanisms to Therapeutics

edited by Georg Thomas Wondrak

submission deadline 1 Nov 2025 | 2 articles | Viewed by 3587 | Submission Open

Keywords: malignant melanoma; cutaneous melanoma; uveal melanoma; drug resistance; targeted therapeutics; immune checkpoint inhibitors; targeted therapeutics; BRAF inhibitors; MEK inhibitors; drug discovery; molecular targets; melanoma diagnostics; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Thoracic Oncology Research

edited by

Domenico Galetta

submission deadline 1 Nov 2025 | 1 articles | Viewed by 2258 | Submission Open

Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Targeting TGF-β as a Marker and Pharmacological Target against Cancer

edited by

Elisabetta Aldieri

submission deadline 1 Nov 2025 | Viewed by 372 | Submission Open

Keywords: TGF-β ; cancer; tumorigenesis; metastasis; epithelial– mesenchymal transition (EMT); marker; therapy

(This special issue belongs to the Section Tumor Microenvironment)

Neuro-Immune Orchestration in Brain Tumors: From Molecular Signatures to Therapeutic Innovation

edited by

Mitsugu Fujita

, Masasuke Ohno and Shunichiro Kuramitsu

submission deadline 1 Nov 2025 | Viewed by 183 | Submission Open

Keywords: neuro-immunology; brain tumor microenvironment; immunotherapy; molecular signatures; tumor-immune interactions

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth

edited by

Ralf Landgraf

submission deadline 1 Nov 2025 | Viewed by 164 | Submission Open

Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction

(This special issue belongs to the Section Cancer Biomarkers)

Targeted Therapy for Liver Metastases

edited by

Gianluca Rompianesi

and

Jacopo Lanari

submission deadline 1 Nov 2025 | Viewed by 156 | Submission Open

Keywords: targeted therapy; liver metastases; biological therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Prostate Biopsy: From Innovative Imaging Modalities to Optimized Detection Strategies

edited by

Fabio Zattoni

submission deadline 1 Nov 2025 | Viewed by 140 | Submission Open

Keywords: prostate biopsy; PSMA PET; systematic biopsies; targeted biopsies; transrectal biopsies; transperineal biopsies; cost-effectiveness; perilesional biopsy; PCa detection; imaging modalities

(This special issue belongs to the Section Methods and Technologies Development)

Novel Research on the Diagnosis and Treatment of Melanoma

edited by Roberta Giuffrida, Stefania Guida,

Caterina Dianzani

and

Claudio Conforti

submission deadline 5 Nov 2025 | 3 articles | Viewed by 3473 | Submission Open

Keywords: melanoma; diagnosis; treatment; nevi; noninvasive imaging; targeted therapy; targeted diagnosis; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Advancing Hepatocellular Imaging: Innovations in Diagnosis, Prognosis, and Treatment Response Assessment

edited by

Laurent Dercle

and Fatima Zohra Mokrane

submission deadline 5 Nov 2025 | Viewed by 471 | Submission Open

Keywords: hepatocellular imaging; diagnosis; prognosis; treatment

(This special issue belongs to the Section Cancer Therapy)

Advances of Particle Therapy in Prostate Cancer—2nd Edition

edited by

Xinning Wang

submission deadline 5 Nov 2025 | Viewed by 179 | Submission Open

Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT

(This special issue belongs to the Section Cancer Therapy)

Advances in Medical Imaging for Cancer Detection and Diagnosis

edited by Claudia R. Mello-Thoms and Mark Anastasio

submission deadline 7 Nov 2025 | 1 articles | Viewed by 1166 | Submission Open

Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Interventional Oncology: Advances in Cancer Care

edited by

Mina S. Makary

submission deadline 7 Nov 2025 | 1 articles | Viewed by 930 | Submission Open

Keywords: interventional oncology; image guided; cancer care; quality of life

(This special issue belongs to the Section Methods and Technologies Development)

Hematological Malignancie: Progress and Challenges

edited by Lucas Coelho Arruda and Arwen Stikvoort

submission deadline 7 Nov 2025 | Viewed by 129 | Submission Open

Keywords: hematological malignancies; blood cancers; leukemia; lymphoma; multiple myeloma; immunotherapy; CAR-T-cell therapy; stem cell therapies; cell-based treatments; patient outcomes; immunoregulation; personalized medicine; molecular pathways; clinical Immunology

(This special issue belongs to the Section Cancer Therapy)

Upper Tract Urothelial Carcinoma: Current Knowledge and Perspectives

edited by Katie S. Murray and Saum Ghodoussipour

submission deadline 10 Nov 2025 | 2 articles | Viewed by 931 | Submission Open

Keywords: upper tract urothelial carcinoma; upper tract disease; urothelial cell carcinoma

(This special issue belongs to the Section Cancer Therapy)

Advances in Pleural and Peritoneal Mesothelioma

edited by

Rossella Bruno

submission deadline 10 Nov 2025 | Viewed by 159 | Submission Open

Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression

(This special issue belongs to the Section Molecular Cancer Biology)

Targeted Therapy of Pediatric Cancer (2nd Edition)

edited by

Günther H.S. Richter

submission deadline 10 Nov 2025 | Viewed by 154 | Submission Open

Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies

(This special issue belongs to the Section Pediatric Oncology)

Genetics in Hematological Malignancies

edited by

Monika Lejman

submission deadline 10 Nov 2025 | Viewed by 117 | Submission Open

Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling

(This special issue belongs to the Section Molecular Cancer Biology)

Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy

edited by

Ravindran Caspa Gokulan

and

Francis Ali-Osman

submission deadline 10 Nov 2025 | Viewed by 103 | Submission Open

Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention

(This special issue belongs to the Section Molecular Cancer Biology)

Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment

edited by Luca Milone and Abid Qureshi

submission deadline 14 Nov 2025 | Viewed by 10 | Submission Open

Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Outcomes in Urologic Cancers

edited by

Simone Morra

and Pierre Karakiewicz

submission deadline 15 Nov 2025 | 15 articles | Viewed by 30745 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Breast Cancer: Biomarkers of Diagnosis and Prognosis

edited by

Andrew R. Green

and Sarah J. Storr

submission deadline 15 Nov 2025 | 6 articles | Viewed by 8336 | Submission Open

Keywords: breast cancer; biomarker; diagnosis; prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Brain Metastases: From Mechanisms to Treatment

edited by Dawen Zhao and Michael Chan

submission deadline 15 Nov 2025 | 6 articles | Viewed by 7932 | Submission Open

Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

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