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Brain Tumors—Related Cognitive Impairment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 15 October 2026 | Viewed by 992

Special Issue Editors


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Guest Editor
Department of Neurosurgery, Erasmus MC-University Medical Center, Doctor Molewaterplein 40, 3015 GE Rotterdam, The Netherlands
Interests: aphasia; language assessment; brain tumor; awake brain surgery; cognition

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Guest Editor
Department of Neurology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
Interests: clinical neuropsychology; cognition; behavior; neurosurgery; gliomas

Special Issue Information

Dear Colleagues,

We are pleased to announce a call for papers for a Special Issue of the journal Cancers entitled "Brain Tumors—Related Cognitive Impairment". This Special Issue aims to provide a platform for the latest research and developments in understanding the effects of brain tumors and their treatments on cognitive functions in patients. We invite you to submit original research articles and reviews that explore various aspects of this important topic, including but not limited to the following:

The effects of specific treatments (surgery, chemotherapy, radiation, etc.) in brain tumors on cognitive function, including aphasia. Interventions and strategies to mitigate cognitive decline in patients with brain tumors. Patient (proxy)-reported outcomes on cognitive functions before and/or after brain tumor treatment.

We believe that your insights and contributions will significantly enrich the field of brain tumor-related cognitive impairment and provide valuable information for researchers and clinicians.

We look forward to hearing from you.

Warm regards,

Dr. Djaina Satoer
Dr. Anne Marie Buunk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aphasia
  • cognition
  • brain tumor
  • surgery
  • adjuvant treatment
  • rehabilitation

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Published Papers (1 paper)

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Research

14 pages, 1988 KB  
Article
Gray Matter Volumetry and Cognitive Functioning in Pediatric Posterior Fossa Tumor Survivors
by Kristien Bullens, Charlotte Sleurs, Jeroen Blommaert, Karen Van Beek, Jurgen Lemiere and Sandra Jacobs
Cancers 2026, 18(3), 495; https://doi.org/10.3390/cancers18030495 - 2 Feb 2026
Viewed by 539
Abstract
Background/Objectives: Posterior fossa tumors (PFTs) often require radiotherapy which may damage both cortical and subcortical brain tissue. We examined voxel-based and region-based gray matter volume (GMV) alterations and explored their relation to cognitive functioning. Methods: Using T1-weighted MR imaging, intelligence scores [...] Read more.
Background/Objectives: Posterior fossa tumors (PFTs) often require radiotherapy which may damage both cortical and subcortical brain tissue. We examined voxel-based and region-based gray matter volume (GMV) alterations and explored their relation to cognitive functioning. Methods: Using T1-weighted MR imaging, intelligence scores from the Wechsler Adult Intelligence Scale-IV (WAIS-IV), and domain scores for language, learning, and memory, complex attention and cognitive flexibility were investigated in 18 of 21 assessed PFT survivors and 21 matched controls. GMV was quantified with voxel-based and region-based volumetry, compared among groups (controls versus survivors, irradiated versus non-irradiated survivors), and correlated with cognitive performance. Results: Survivors showed reduced GMV in two voxel-based clusters, located in the left occipital fusiform area and the left pallidum. Region-based analyses showed lower GMV in survivors located in subcortical areas, while higher GMV was observed in the left inferior temporal region. Survivors who received craniospinal radiation exhibited reductions in GMV in bilateral thalami, right ventral diencephalon, and central corpus callosum, and higher GMV in the bilateral middle temporal regions. Compared to controls, survivors scored lower for all cognitive domains, except for complex attention and cognitive flexibility. Amongst survivors, the GMV of the bilateral thalami and right ventral diencephalon correlated positively with working memory. Conclusions: Overall, PFT survivors demonstrated both alterations in GMV and cognitive functioning, with the most pronounced GMV deviations found in those treated with craniospinal radiation. Reduced GMV was associated with poorer cognitive performance. Full article
(This article belongs to the Special Issue Brain Tumors—Related Cognitive Impairment)
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