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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1295 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

Advanced Research in Surgical Treatment for Spinal Tumors

edited by Alessandro Gasbarrini, Stefano Bandiera and

Giuseppe Tedesco

submission deadline 31 Dec 2025 | 1 articles | Viewed by 696 | Submission Open

Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy

(This special issue belongs to the Section Cancer Therapy)

Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation

edited by

Barbara Kofler

, Niels van Heerbeek, Giulia Molinari and Benedikt Hofauer

submission deadline 31 Dec 2025 | Viewed by 557 | Submission Open

Keywords: facial nerve; facial nerve reanimation; head and neck cancer; facial reconstructive surgery

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes

edited by

Andrea Dell'Amore

and

Alessio Campisi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 536 | Submission Open

Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment

(This special issue belongs to the Section Clinical Research of Cancer)

Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

edited by Erlinda M. Gordon,

Sant P. Chawla

and Frederick L. Hall

submission deadline 31 Dec 2025 | Viewed by 434 | Submission Open

Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy

edited by Antonio Pontoriero

submission deadline 31 Dec 2025 | Viewed by 378 | Submission Open

Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation

(This special issue belongs to the Section Cancer Therapy)

Advances in the Pathogenesis of Hematopoietic Neoplasms

edited by

Raju K. Pillai

and

Steven T. Rosen

submission deadline 31 Dec 2025 | Viewed by 359 | Submission Open

Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)

edited by

Roland S. Croner

, Ibrahim Dagher and

Andrew A. Gumbs

submission deadline 31 Dec 2025 | Viewed by 353 | Submission Open

Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management

edited by

Neville F. Hacker

and

Jacobus van der Velden

submission deadline 31 Dec 2025 | Viewed by 346 | Submission Open

Keywords: primary cytoreduction; interval cytoreduction; neoadjuvant chemotherapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Dec 2025 | 2 articles | Viewed by 323 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

Research Challenges in Adolescent and Young Adult Cancer

edited by

Lorna A. Fern

and Jeremy Lewin

submission deadline 31 Dec 2025 | Viewed by 321 | Submission Open

Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers

(This special issue belongs to the Section Pediatric Oncology)

Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas

edited by

Ronald R. de Krijger

, Verena Wiegering and

Maria Candida Barisson Villares Fragoso

submission deadline 31 Dec 2025 | Viewed by 252 | Submission Open

Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor

(This special issue belongs to the Section Pediatric Oncology)

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 31 Dec 2025 | Viewed by 235 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Head and Neck Cancer Surgery and Rehabilitation: A Bridge Between Medicine and Dentistry for Reconstruction with Regeneration

edited by

Shahram M. Ghanaati

and Samuel Ebele Udeabor

submission deadline 31 Dec 2025 | Viewed by 229 | Submission Open

Keywords: oral squamous cell carcinoma; oral cancer; head and neck cancer; odontogenic tumors; OSCC management; tumor recurrence; tumor metastasis; adjuvant therapy; biomaterials for maxillofacial reconstruction; tissue regeneration; cancer rehabilitation

(This special issue belongs to the Section Cancer Therapy)

Oxidative Stress-Mediated Regulation of Specific Signaling Pathways in Skin Cancers

edited by

Sanjay Premi

and

Jyoti Srivastava

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: reactive oxygen species; reactive nitrogen species; oxidative stress; epigenetic regulation; UV-exposure; skin pigmentation; skin cancer; melanoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancers in Chronic HIV Infection

edited by Diego Ripamonti

submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open

Keywords: cancer; HIV; AIDS; cancer screening; hematologic malignancy; Kaposi sarcoma; HPV; anal cancer; lymphoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Neoadjuvant Chemotherapy in Pancreatic Cancer

edited by

Casper H. J. Van Eijck

submission deadline 31 Dec 2025 | Viewed by 209 | Submission Open

Keywords: neoadjuvant chemotherapy; pancreatic cancer; treatment decision

(This special issue belongs to the Section Cancer Therapy)

Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives

edited by

Paola Bellosta

submission deadline 31 Dec 2025 | Viewed by 185 | Submission Open

Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models

(This special issue belongs to the Section Cancer Biomarkers)

Patients’ Perspective in Gynecological Cancer

edited by

Jalid Sehouli

submission deadline 31 Dec 2025 | Viewed by 184 | Submission Open

Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics

edited by Lingbin Meng

submission deadline 31 Dec 2025 | Viewed by 182 | Submission Open

Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies

edited by

Francesco Del Giudice

submission deadline 31 Dec 2025 | Viewed by 179 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Hippo Signaling in Cancer (2nd Edition)

edited by

Michel Ouellette

and

Ying Yan

submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open

Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance

(This special issue belongs to the Section Tumor Microenvironment)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Advances in Minimally Invasive Surgery for Colorectal Cancer

edited by Jonathan S. Abelson and Christine A. Schad

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival

(This special issue belongs to the Section Cancer Therapy)

Oncogenetics of Colorectal Cancer (2nd Edition)

edited by

Muhammad Kibriya

and Marc Bissonnette

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA

(This special issue belongs to the Section Cancer Pathophysiology)

ALK in Cancer: Lessons from the Future (2nd Edition)

edited by

Petros Christopoulos

and

Richard Bayliss

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 10 Jan 2026 | 2 articles | Viewed by 1648 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

Neoadjuvant Therapy of Breast Cancer

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 15 Jan 2026 | 9 articles | Viewed by 24048 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities

edited by

Christopher Kobierzycki

and

Piotr Dzięgiel

submission deadline 15 Jan 2026 | 7 articles | Viewed by 14959 | Submission Open

Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)

edited by Wei Chen, Fei Li and

Qiang Jeremy Wen

submission deadline 15 Jan 2026 | 4 articles | Viewed by 10424 | Submission Open

Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer

edited by Biniam Kidane

submission deadline 15 Jan 2026 | 5 articles | Viewed by 9059 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice

edited by Xiaotong Song

submission deadline 15 Jan 2026 | 4 articles | Viewed by 6465 | Submission Open

Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cell Biology of Cancer Invasion: 2nd Edition

edited by

Hideki Yamaguchi

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2848 | Submission Open

Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage

(This special issue belongs to the Section Cancer Metastasis)

Circulating Tumour DNA and Liquid Biopsy in Oncology

edited by

Yafeng Ma

and Kevin Spring

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2203 | Submission Open

Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection

(This special issue belongs to the Section Cancer Biomarkers)

The Survival of Colon and Rectal Cancer (2nd Edition)

edited by

Susanne Merkel

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Updates on Urothelial Carcinoma

edited by

Toyonori Tsuzuki

and Yasmin Abu-Ghanem

submission deadline 15 Jan 2026 | Viewed by 243 | Submission Open

Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Pediatric Cancer Research from Basic Biology to Experimental Therapy

edited by

Atif Ahmed

submission deadline 16 Jan 2026 | 4 articles | Viewed by 11652 | Submission Open

Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance

(This special issue belongs to the Section Pediatric Oncology)

Survivorship Following Childhood, Adolescent and Young Adult Cancer

edited by Magdalena Balcerek and Judith Gebauer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2433 | Submission Open

Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion

(This special issue belongs to the Section Pediatric Oncology)

Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology

edited by

Olaf Prante

submission deadline 20 Jan 2026 | Viewed by 177 | Submission Open

Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

The Prospect of Nanobiotechnology in Cancers

edited by

Wenpan Li

submission deadline 20 Jan 2026 | Viewed by 167 | Submission Open

Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 Jan 2026 | 2 articles | Viewed by 2472 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 22 Jan 2026 | Viewed by 319 | Submission Open

Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies

edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and

Boguslaw Mikaszewski

submission deadline 22 Jan 2026 | Viewed by 238 | Submission Open

Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches

(This special issue belongs to the Section Cancer Therapy)

Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition

edited by

Shebli Atrash

submission deadline 23 Jan 2026 | 3 articles | Viewed by 6841 | Submission Open

Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | Viewed by 728 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

(This special issue belongs to the Section Cancer Biomarkers)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 Jan 2026 | 3 articles | Viewed by 20537 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers

edited by

Haibo Lin

, Richard A. Amos and Heng Li

submission deadline 30 Jan 2026 | 7 articles | Viewed by 15667 | Submission Open

Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities: Biological, Social, and Environmental Determinants

edited by

Riffat Mehboob

and