Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 59
Special Issue Editors
2. Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA
Interests: MYC; ribosomal proteins; rRNA processing; animal models; ribosomapathies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to a Special Issue on ribosome biogenesis and cancer. Ribosome biogenesis is a fundamental cellular process crucial for cell growth and proliferation. Dysregulation of this process plays a critical role in cancer progression, with tumor cells often exhibiting altered ribosome production, ribosomal proteins, and translation machinery to meet their heightened metabolic and proliferative demands. This emerging field, situated at the intersection of ribosome biology and cancer therapeutics, offers exciting opportunities for targeting the vulnerabilities of tumor cells.
The Special Issue explores the complex mechanisms underlying dysregulated ribosome biogenesis in cancer. We will focus on the roles of ribosomal RNA synthesis, ribosome assembly, and translation initiation in tumor cells, as well as the impact of altered ribosomal proteins and translation factors on oncogenesis and tumorigenesis. The issue will also cover innovative therapeutic strategies targeting ribosome biogenesis, including inhibitors of ribosome production and combinatorial treatments with other cancer therapies. Given the focus on molecular mechanisms and therapeutic strategies, this Special Issue aligns closely with the journal's scope, which addresses cutting-edge research in cancer biology and targeted therapies. We aim to gather at least 10 articles for the Special Issue, and if this number is reached, it may be published in book form. We would be happy to collaborate with you to achieve this goal.
We welcome original research articles and comprehensive review articles in this Special Issue. Suggested research areas include (but are not limited to) the following:
- Mechanisms of dysregulated ribosome biogenesis in cancer, oncoribosomes;
- Ribosomal RNA synthesis, ribosome assembly, and translation initiation in tumor cells;
- Role of ribosomal proteins and translation factors in oncogenesis;
- Impact of nucleolar stress and genomic instability on cancer progression;
- Ribosome intrinsic alterations in cancer;
- Innovative therapeutic strategies targeting ribosome biogenesis;
- Clinical applications of ribosomal protein signatures as cancer biomarkers;
- Ongoing clinical trials investigating ribosome-targeting drugs;
- Contributions from computational biology, functional genomics, and animal models in understanding ribosome biogenesis in cancer.
We look forward to receiving your contributions to this exciting and timely Special Issue.
Best regards,
Dr. Paola Bellosta
Dr. Marianna Penzo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ribosome biogenesis
- ribosomal proteins
- nucleolar stress
- genomic instability
- oncoribosome
- ribosomapathies
- ribosome-targeting drugs
- cancer biomarkers
- animal models
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