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Cancers
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Towards a Personalized Medicine for the Diagnosis and Management of...
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Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 7521

Special Issue Editors

Dr. Diego Raimondo

E-Mail Website
Guest Editor
Department of Gynecology and Obstetrics, Sant’Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Interests: endometriosis; laparoscopic surgery; gynecologic oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Gabriele Centini

E-Mail Website
Guest Editor
Department of Molecular and Reproductive Medicine, University of Siena, 53100 Siena, Italy
Interests: endometriosis; gynaecological surgery; endoscopy; laparoscopic surgery

Special Issue Information

Dear Colleagues,

This Special Issue is aimed toward developing personalized medicine for the diagnosis and management of gynecological cancers.

Gynecological cancers are the most commonly occurring form of cancer among women worldwide. They impact quality of life inaffected patients, disrupt women’s reproductive systems, and have a limited response to treatment at an advanced stage.

However, new technologies and research in the fields of prevention, diagnosis, and treatment are changing this context by supporting both specialists and the patient during their medical journey.

In an ever-more digital- and AI-oriented era, the main challenge of professionals is to tailor the diagnosis and treatment experience to suit individual patients by personalizing medicine used in the management of gynecological cancer women.

Aiming to ensure the right course of treatment for each patient, the scope of this Special Issue includes, but is not limited to, the following topics:

- Selected prevention of oncological diseases;
- Specific diagnostic workup of gynecological cancer;
- Tailoring treatments according to patient and cancer characteristics;
- Assessment performed via dedicated oncological follow-up.

Researchers working in the field of gynecological cancers are encouraged to submit original articles and reviews related to this Special Issue’s scope. Communications, systematic reviews, and meta-analyses are also welcome.

Dr. Diego Raimondo
Dr. Gabriele Centini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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21 pages, 329 KiB  
Review
Management for Cervical Cancer Patients: A Comparison of the Guidelines from the International Scientific Societies (ESGO-NCCN-ASCO-AIOM-FIGO-BGCS-SEOM-ESMO-JSGO)
by Stefano Restaino, Giulia Pellecchia, Martina Arcieri, Giorgio Bogani, Cristina Taliento, Pantaleo Greco, Lorenza Driul, Vito Chiantera, Alfredo Ercoli, Francesco Fanfani, Anna Fagotti, Andrea Ciavattini, Giovanni Scambia, Giuseppe Vizzielli and Gynecologic Oncology Group
Cancers 2024, 16(14), 2541; https://doi.org/10.3390/cancers16142541 - 15 Jul 2024
Cited by 18 | Viewed by 5527
Abstract
Cervical cancer continues to have a significant incidence, despite global efforts in HPV vaccination campaigns. Managing this condition involves a diverse team of healthcare professionals. Research in this field is undergoing a period of great revolution in multiple areas, and international guidelines will [...] Read more.
Cervical cancer continues to have a significant incidence, despite global efforts in HPV vaccination campaigns. Managing this condition involves a diverse team of healthcare professionals. Research in this field is undergoing a period of great revolution in multiple areas, and international guidelines will soon have to adapt to new scientific evidence. This could be true mainly in locally advanced stages, and it could also be true for minimal invasive surgery. This paper aims to summarize and compare the most recent recommendations published by international gynecological oncological societies for patients with cervical cancer. From their comparison, common aspects and disagreements emerged, especially in the diagnostic pathway and follow-up strategies. Several issues that remain to be debated in the literature were addressed and compared, highlighting similarities and differences, from the role of the sentinel lymph node in early stages to that of the adjuvant hysterectomy in locally advanced tumors. On the surgical side, for this last subset of patients, currently, a laparotomic approach is recommended. At the same time, the advent of immunotherapy has just opened up new and promising scenarios in systemic treatment for locally advanced cervical cancer, and international guidelines will soon introduce it into their algorithms. Full article
(This article belongs to the Special Issue Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers)

Other

Jump to: Review

17 pages, 782 KiB  
Systematic Review
Port Site Metastasis in Women with Low- or Intermediate-Risk Endometrial Carcinoma: A Systematic Review of Literature
by Antonio Raffone, Diego Raimondo, Alessio Colalillo, Arianna Raspollini, Daniele Neola, Antonio Travaglino, Virginia Vargiu, Luigi Carlo Turco, Maria Giovanna Vastarella, Renato Seracchioli, Francesco Fanfani, Luigi Cobellis and Francesco Cosentino
Cancers 2024, 16(15), 2682; https://doi.org/10.3390/cancers16152682 - 27 Jul 2024
Viewed by 1361
Abstract
Background: Port site metastasis (PSM) has been reported as a rare metastasis in women with endometrial carcinoma (EC). However, even more rarely, it has also been described in patients with low- or intermediate-risk EC. Unfortunately, knowledge appears limited on the topic. Objectives: Our [...] Read more.
Background: Port site metastasis (PSM) has been reported as a rare metastasis in women with endometrial carcinoma (EC). However, even more rarely, it has also been described in patients with low- or intermediate-risk EC. Unfortunately, knowledge appears limited on the topic. Objectives: Our objective was to systematically review the literature on PSM in low- or intermediate-risk EC. Search Strategy: A systematic review of the literature was performed by searching six electronic databases from their inception to January 2023. Selection Criteria: We included in our research all peer-reviewed studies which reported PSM in low- or intermediate-risk EC women. Data Collection and Analysis: Data on PSM were collected from the included studies and compared. Results: Seven studies with 13 patients (including our case) were included in the systematic review. PSM was reported in patients with low- or intermediate-risk EC independently from tumor histologic characteristics, endoscopic approach, lymph node staging type, number and site of the port, route of specimen removal, prevention strategies for PSM, and concomitant metastases. Among several proposed treatments, local resection and radiotherapy with or without chemotherapy might be the most appropriate ones. Nevertheless, the prognosis appears poor. Conclusions: In patients with low- or intermediate-risk EC, PSM can occur as a rare metastasis, regardless of tumor characteristics or surgical strategy. Unfortunately, no consensus has been reached regarding treatment, and the prognosis appears poor. Additional cases are needed in order to confirm and further explore this rare EC metastasis. Full article
(This article belongs to the Special Issue Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers)
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