Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 258
Special Issue Editor
Special Issue Information
Dear Colleagues,
External beam radiation therapy (EBRT) is a crucial component of treating many gynecologic malignancies combined modality. Stereotactic Body Radiotherapy (SBRT) has a limited role in managing gynecologic malignancies due to curative potential with brachytherapy and a better-suited volumetric radiation therapy. However, clinical scenarios exist where SBRT may be a safe and effective option for gynecologic cancer patients, offering a convenient and cost-effective alternative to EBRT.
Given the field of radiation oncology's interest in the role of SBRT overall and the need to define the role of SBRT in the management of gynecologic malignancies, it is important to highlight practical considerations pertaining to patient selection, fractionation scheme, target delineation, and planning objectives.
The role of concurrent or adjuvant systemic therapy with standard fractionated EBRT in gynecologic cancers is well supported in both safety and outcomes, but the role of SBRT in relation to systemic therapy is less well defined.
Gynecologic cancers are attractive targets for immune checkpoint blockade, and Immunotherapy agents may be combined with definitive chemoradiotherapy to enhance radiosensitivity and, thus, local control for unresected disease and distant micrometastatic spread. For patients with metastatic disease, immune checkpoint blockade in combination with SBRT is being evaluated as a strategy for immune activation and tumor cytoreduction.
This Special Issue aims to provide a practical framework to deliver SBRT to oligometastatic, recurrent/persistent, and primary gynecologic malignancies to describe the immunogenic potential of radiation through clinical observation and preclinical study.
In this Special Issue, original research articles and reviews are welcome.
I look forward to receiving your contributions.
Prof. Dr. Antonio Pontoriero
Guest Editor
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Keywords
- SBRT
- gynecologic cancer
- chemoradiotherapy
- immunotherapy
- oligometastatic
- oligoecurrent
- oligopersistent
- reirradiation
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