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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 30 Jan 2026 | Viewed by 196 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

Metastasis in Tumor Immunity: Current Perspectives

edited by

Ulrike Stein

, Sebastian Torke and

Wolfgang Walther

submission deadline 30 Jan 2026 | Viewed by 191 | Submission Open

Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints

(This special issue belongs to the Section Cancer Metastasis)

Advances in Drug Delivery for Cancer Therapy

edited by

Ashakumary Lakshmikuttyamma

submission deadline 31 Jan 2026 | 9 articles | Viewed by 39106 | Submission Open

Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle

(This special issue belongs to the Section Cancer Drug Development)

How COVID-19 Affects Cancer Patients

edited by

Maria Fiore

submission deadline 31 Jan 2026 | 15 articles | Viewed by 34667 | Submission Open

Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives

edited by

and

submission deadline 31 Jan 2026 | 17 articles | Viewed by 30906 | Submission Open

Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation

(This special issue belongs to the Section Cancer Therapy)

Genetics and Epigenetics of Gynecological Cancer

edited by

Carmela De Marco

submission deadline 31 Jan 2026 | 10 articles | Viewed by 29587 | Submission Open

Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance

(This special issue belongs to the Section Cancer Pathophysiology)

CAR T Cells in Lymphoma and Multiple Myeloma

edited by

Javier Munoz

and

Julia Erin Wiedmeier-Nutor

submission deadline 31 Jan 2026 | 7 articles | Viewed by 23893 | Submission Open

Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers

edited by Zaed Z.R. Hamady

submission deadline 31 Jan 2026 | 7 articles | Viewed by 22909 | Submission Open

Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Emerging Research on Primary Brain Tumors

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jan 2026 | 6 articles | Viewed by 16514 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jan 2026 | 8 articles | Viewed by 16166 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition

edited by Kellie Toohey

submission deadline 31 Jan 2026 | 10 articles | Viewed by 13552 | Submission Open

Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pathology and Treatment of Triple-Negative Breast Cancer

edited by

Ramadevi Subramani

submission deadline 31 Jan 2026 | 4 articles | Viewed by 11853 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Implementation of Physical Activity Promotion in Cancer Care

edited by Sarah Hardcastle

submission deadline 31 Jan 2026 | 4 articles | Viewed by 10271 | Submission Open

Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Tumor Microenvironment: Interplay Between Immune Cells

edited by Jared Rowe and Kristen E. Pauken

submission deadline 31 Jan 2026 | 5 articles | Viewed by 9815 | Submission Open

Keywords: tumor immune microenvironment; metabolic microenvironment; immune cells

(This special issue belongs to the Section Tumor Microenvironment)

Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition

edited by

Antonio Piñero-Madrona

submission deadline 31 Jan 2026 | 6 articles | Viewed by 8380 | Submission Open

Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Oncology Imaging: 2nd Edition

edited by

Li Liu

and

Yicheng Ni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7720 | Submission Open

Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics

(This special issue belongs to the Section Methods and Technologies Development)

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma

edited by

Susana Cedrés

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6077 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Cancer Screening and Primary Care

edited by Marievelisse Soto-Salgado

submission deadline 31 Jan 2026 | 5 articles | Viewed by 5224 | Submission Open

Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies

edited by

Emi Dika

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5108 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment

The Role of Apoptosis and Autophagy in Cancer

edited by

Souren Paul

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4939 | Submission Open

Keywords: apoptosis; cell death; tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Oral Cancer: The Latest Advances in Clinical and Basic Research (Second Edition)

edited by

Kenji Yamagata

and Fumihiko Uchida

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4429 | Submission Open

Keywords: oral cancer; clinical research; basic research; surgery; radiotherapy; chemotherapy; molecular biology; immune checkpoint inhibitor

(This special issue belongs to the Section Clinical Research of Cancer)

Prediction of Melanoma

edited by

Irene Stefanaki

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4013 | Submission Open

Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Studies and Outcomes in Urologic Cancer

edited by Nikolaos Pyrgidis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3882 | Submission Open

Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Nanomedicine-Based Cancer Immunotherapy

edited by Navin Kumar Verma,

Rajeev Parameswaran

and

Manash Paul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2865 | Submission Open

Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations

edited by

Alchiede Simonato

and

Nicola Pavan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2852 | Submission Open

Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2738 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2670 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2271 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition

edited by

Nicolas Golse

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2239 | Submission Open

Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid

(This special issue belongs to the Section Transplant Oncology)

Cancers Hijack Immune Surveillance and Tumor Microenvironment Leading to Immune Evasion

edited by

Yona Keisari

, Viktor Umansky and

Rostyslav Bilyy

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2044 | Submission Open

Keywords: anti-tumor immunity; cancer immunotherapy; immune evasion; immune response modulation; immunosuppression; immune surveillance; manipulating IR components function and migration; metabolic modulation of the TME; metabolic reprogramming; tumor-associated immune cells; tumor microenvironment (TME)

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Trials and Outcomes for Non-Small Cell Lung Cancer

edited by

Ana Rodrigues

and

António Araújo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1859 | Submission Open

Keywords: non-small cell lung cancer; oncogenic alterations; clinical trial; systemic therapy; targeted therapy; immunotherapy; radiotherapy; real-world data; surgery; drug development

(This special issue belongs to the Section Clinical Research of Cancer)

Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches

edited by

Lucía Ortiz-Comino

, Avraham Eisbruch and

Ángela González-Santos

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1850 | Submission Open

Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions

(This special issue belongs to the Section Cancer Therapy)

Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1608 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

edited by

Matteo Donadon

and

Guido Torzilli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1408 | Submission Open

Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advanced Glycation End-Products and Its Receptors in Cancer Progression

edited by Bhaumik B. Patel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1384 | Submission Open

Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)

(This special issue belongs to the Section Tumor Microenvironment)

Nutrition in Survivors with Advanced Cancer: The Role of Appetite, Muscle Wasting, Obesity, and Altered Body Composition

edited by Egidio Del Fabbro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: advanced cancer; nutrition; wasting; body composition; multimodal

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Emerging Technologies in Thoracic Surgery

edited by Filippo Lococo and

Carolina Sassorossi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 841 | Submission Open

Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 773 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

New Insights in Nanomedicine and Targeted Drugs for Breast Cancer

edited by

Maria Gazouli

, Gennaro Sanità, Alessandro Venuta and Rosarita Nasso

submission deadline 31 Jan 2026 | Viewed by 437 | Submission Open

Keywords: breast cancer; nanoparticles; active targeting; BC; nanomedicine

(This special issue belongs to the Section Cancer Drug Development)

The Cancer Stem Cells and the Quiescence

edited by

Bhopal Mohapatra

submission deadline 31 Jan 2026 | Viewed by 395 | Submission Open

Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)

edited by

Naoshi Nishida

submission deadline 31 Jan 2026 | 1 articles | Viewed by 359 | Submission Open

Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence

(This special issue belongs to the Section Molecular Cancer Biology)

Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis

edited by

Vincent Balaya

Marcin Sniadecki

and Thomas Gaillard

submission deadline 31 Jan 2026 | Viewed by 343 | Submission Open

Keywords: cervical cancer; lymph nodes; metastasis; isolated Tumor Cells; sentinel lymph node; non-sentinel lymph node; tumor-draining lymph nodes; microenvironment; one-step nucleic acid amplification; imaging

(This special issue belongs to the Section Tumor Microenvironment)

Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by Shuji Isaji

submission deadline 31 Jan 2026 | Viewed by 250 | Submission Open

Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2026 | Viewed by 220 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications

edited by

Whi-An Kwon

submission deadline 31 Jan 2026 | Viewed by 199 | Submission Open

Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Cancer Biology)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 31 Jan 2026 | Viewed by 186 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by