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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2805 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2686 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer

edited by

Carlo Signorelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2663 | Submission Open

Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Metastasis)

Myeloma: Pathogenesis and Targeted Therapies

edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2626 | Submission Open

Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis

(This special issue belongs to the Section Tumor Microenvironment)

CT/MRI/PET in Cancer

edited by

Dávid Sipos

Ritter Zsombor

and

Elif Hindié

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2610 | Submission Open

Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration

(This special issue belongs to the Section Methods and Technologies Development)

Prostate Cancer Epidemiology and Genetics: 2nd Edition

edited by

Steven Narod

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2476 | Submission Open

Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2232 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2080 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1911 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next

edited by

Luca Marzi

and

Rodolfo Sacco

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1853 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1846 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

edited by

Carlo Ronsini

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1819 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Cancer Therapy)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1743 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

The Latest Advancements in Cutaneous Melanoma

edited by Zhenyu Ji

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1681 | Submission Open

Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers

(This special issue belongs to the Section Cancer Therapy)

Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment

edited by

Wing Keung Chan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1592 | Submission Open

Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis

(This special issue belongs to the Section Cancer Therapy)

Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes

edited by

Candida Fasano

and Vittoria Disciglio

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1555 | Submission Open

Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant

(This special issue belongs to the Section Cancer Pathophysiology)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1518 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies

edited by

Shilpi Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1318 | Submission Open

Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers

edited by Ting-Tai Yen and Eugene Patrick Toy

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1304 | Submission Open

Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)

edited by

Emad H. Kandil

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer

edited by

Masaru Sakamoto

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1079 | Submission Open

Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT

Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology

edited by Evrim Erdemogľu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Image-Guided Treatment of Liver Tumors

edited by

Maarten L. J. Smits

and Niek Wijnen

submission deadline 30 Apr 2026 | 2 articles | Viewed by 632 | Submission Open

Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods

edited by Peter C. Angeletti

submission deadline 30 Apr 2026 | 1 articles | Viewed by 593 | Submission Open

Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Molecular Pathogenesis of T-Cell Lymphoma

edited by

Richard Flavin

submission deadline 30 Apr 2026 | Viewed by 450 | Submission Open

Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Medical Treatment for Urological Cancers

edited by

Jozefina Casuscelli

submission deadline 30 Apr 2026 | Viewed by 438 | Submission Open

Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

The Biomarkers of Oral Cancer

edited by

Yasumasa Kakei

submission deadline 30 Apr 2026 | 1 articles | Viewed by 405 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer

edited by

Felipe A. Calvo

submission deadline 30 Apr 2026 | Viewed by 399 | Submission Open

Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost

(This special issue belongs to the Section Cancer Therapy)

The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications

edited by

Mariarosaria Conte

submission deadline 30 Apr 2026 | Viewed by 357 | Submission Open

Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application

(This special issue belongs to the Section Tumor Microenvironment)

Cancer Inhibitory Receptors and Related Cancer Immunotherapy

edited by Keqiang Chen, Feng Zhu and Xin Li

submission deadline 30 Apr 2026 | Viewed by 347 | Submission Open

Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeted Therapies for Pediatric Nervous System Tumors

edited by

Mohamed S. Abdelbaki

and Nicole Brossier

submission deadline 30 Apr 2026 | Viewed by 340 | Submission Open

Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Pediatric Oncology)

Current Concept and Management of Pediatric ATRTs—2nd Edition

edited by

Tadanori Tomita

and Alicia C. Lenzen

submission deadline 30 Apr 2026 | 1 articles | Viewed by 330 | Submission Open

Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors

(This special issue belongs to the Section Pediatric Oncology)

Precision Medicine in Hematological Malignancies: Current Insights and Future Directions

edited by Giuseppe Saglio and Mohamed Yassin

submission deadline 30 Apr 2026 | Viewed by 257 | Submission Open

Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Therapy)

Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy

edited by Heena Kumra and Makoto Noda

submission deadline 30 Apr 2026 | Viewed by 257 | Submission Open

Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Cancer Pathophysiology)

The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment

edited by

Michael I. Koukourakis

and

Athanasia Mitsala

submission deadline 30 Apr 2026 | Viewed by 231 | Submission Open

Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers

edited by Patriciu Achimas-Cadariu and

Laurentia Nicoleta Gales

submission deadline 30 Apr 2026 | Viewed by 220 | Submission Open

Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers

Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment

edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna

submission deadline 30 Apr 2026 | Viewed by 218 | Submission Open

Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics

(This special issue belongs to the Section Methods and Technologies Development)

Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications

edited by

Hong Chang

and

Shamila D. Alipoor

submission deadline 30 Apr 2026 | Viewed by 174 | Submission Open

Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes

(This special issue belongs to the Section Cancer Therapy)

Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer

edited by

Benny Abraham Kaipparettu

submission deadline 30 Apr 2026 | Viewed by 172 | Submission Open

Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

The Changing Paradigms in the Management of Thyroid Cancer

edited by

Antonio M. Matrone

submission deadline 30 Apr 2026 | Viewed by 167 | Submission Open

Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

The Role of Ferroptosis in Cancer (2nd Edition)

edited by Wei Li

submission deadline 30 Apr 2026 | Viewed by 154 | Submission Open

Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)

edited by

Nirmish Singla

and

Yasser Ged

submission deadline 30 Apr 2026 | Viewed by 149 | Submission Open

Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy

(This special issue belongs to the Section Cancer Metastasis)

Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes

edited by

Gabriela Ilie

submission deadline 30 Apr 2026 | Viewed by 141 | Submission Open

Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers

edited by

Giorgia Mangili

and

Raffaella Cioffi

submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open

Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up

(This special issue belongs to the Section Cancer Therapy)

Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy

edited by

Masaharu Seno

and

Mary J.C. Hendrix

submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open

Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft

(This special issue belongs to the Section Cancer Therapy)

Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life

edited by

Cristina García-Muñoz

Javier Martinez-Calderon

and Juan Carlos Hernández-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open

Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Management of Orbital Tumors

edited by

Peerooz Saeed

submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open

Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques

(This special issue belongs to the Section Clinical Research of Cancer)

PARP Inhibitors in Cancers: 2nd Edition

edited by

Jose Manuel Rodriguez-Vargas

submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open

Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells

(This special issue belongs to the Section Molecular Cancer Biology)

Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours

edited by Crispin T. Hiley and Iain Phillips

submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open

Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR

(This special issue belongs to the Section Cancer Therapy)

EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer

edited by

Francesca Iommelli

submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open

Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer

(This special issue belongs to the Section Cancer Therapy)

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