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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology

edited by

Ira-Ida Skvortsova

Johjong Huang

and

Hsin-Hua Lee

submission deadline 5 Dec 2025 | 5 articles | Viewed by 13195 | Submission Open

Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects

(This special issue belongs to the Section Tumor Microenvironment)

Mesothelioma—from Diagnosis to Treatment

edited by

Nobukazu Fujimoto

submission deadline 5 Dec 2025 | 4 articles | Viewed by 11447 | Submission Open

Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1

(This special issue belongs to the Section Cancer Therapy)

Paradigm Shifts in Gynaecological Oncology Surgery

edited by

Faiza Gaba

submission deadline 5 Dec 2025 | 3 articles | Viewed by 6404 | Submission Open

Keywords: gynecological surgery; genomics risk management; survivorship health economics

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy

edited by

Alexander Barrow

and Julian Vivian

submission deadline 5 Dec 2025 | 2 articles | Viewed by 4059 | Submission Open

Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Research on Thoracic Cancer

edited by

Yuichi Saito

and Hiroyuki Adachi

submission deadline 6 Dec 2025 | 3 articles | Viewed by 6395 | Submission Open

Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation

(This special issue belongs to the Section Clinical Research of Cancer)

Preclinical and Clinical Research on the Efficacy of Anticancer Drugs

edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica

submission deadline 10 Dec 2025 | 2 articles | Viewed by 6965 | Submission Open

Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Clinical Research of Cancer)

New Advances in Oncology Research and Practice

edited by

Dumitru A. Iacobas

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1482 | Submission Open

Keywords: cancer bioinformatics; cancer biology; cancer diagnosis; cancer genomics; cancer immunotherapy; corona virus and cancer; cancer molecular mechanisms; organ-specific cancers; palliative cancer care

(This special issue belongs to the Section Cancer Therapy)

The Impact of Treatment Resistance in Prostate Cancer

edited by

Noel Andrew Warfel

submission deadline 10 Dec 2025 | Viewed by 210 | Submission Open

Keywords: prostate cancer; treatment resistance; progression; drug target; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer Metastasis—Diagnosis and Treatment

edited by Arnulf Stenzl

submission deadline 12 Dec 2025 | 1 articles | Viewed by 1104 | Submission Open

Keywords: prostate cancer; metastasis; hormone-sensitive; castration-resistant prostate cancer; imaging; PSMA; ligand therapy; sequence; oligometastatic; biomarker

(This special issue belongs to the Section Cancer Metastasis)

Clinical Treatment and Prognostic Factors of Urologic Cancer

edited by

Hiroaki Iwamoto

submission deadline 15 Dec 2025 | 13 articles | Viewed by 37743 | Submission Open

Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment

(This special issue belongs to the Section Cancer Therapy)

New Biomarkers in Cancers 2nd Edition

edited by

Jochen Sven Utikal

submission deadline 15 Dec 2025 | 13 articles | Viewed by 30990 | Submission Open

Keywords: cancer; biomarker; molecule; serum; tumor; liquid biopsy; circulating tumor DNA; DNA; RNA; protein; circulating tumor cells; prognosis; prediction; indicator; traceable substance

(This special issue belongs to the Section Cancer Biomarkers)

Biomarkers for Treatment Prediction, Prognosis and Early Detection of Gynecologic Cancer

edited by Brian S Finkelman, Rachelle P Mendoza and Hani Katerji

submission deadline 15 Dec 2025 | 10 articles | Viewed by 22770 | Submission Open

Keywords: biomarkers; endometrial cancer; uterine cancer; cervical cancer; ovarian cancer; vulvar cancer; treatment prediction; prognosis; early detection

(This special issue belongs to the Section Cancer Biomarkers)

Molecular Markers and Targeted Therapy for Hepatobiliary Tumors

edited by Masaki Kuwatani

submission deadline 15 Dec 2025 | 7 articles | Viewed by 20971 | Submission Open

Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy

(This special issue belongs to the Section Cancer Therapy)

New Molecular Targets and Emerging Approaches to Target Cancer Stem Cells

edited by

José Braganca

and Mónica Fernandes

submission deadline 15 Dec 2025 | 4 articles | Viewed by 12385 | Submission Open

Keywords: cancer stem cells; plasticity; microenvironmental heterogeneity; resistance to therapy; targeted therapies; immune surveillance avoidance; invasion; metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Genome Instability and Human Cancer

edited by Jian Ouyang

submission deadline 15 Dec 2025 | 3 articles | Viewed by 11864 | Submission Open

Keywords: genomic instability; cancer progression; drug resistance; tumor-targeted immunity

(This special issue belongs to the Section Tumor Microenvironment)

Advances in B-Cell Lymphoma: From Diagnostics to Cure

edited by

Leo I. Gordon

and Megan E. Melody

submission deadline 15 Dec 2025 | 5 articles | Viewed by 11511 | Submission Open

Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies

(This special issue belongs to the Section Cancer Therapy)

Endometrial Cancer—Diagnosis and Treatment

edited by

Alberto Izzotti

and

Fabio Barra

submission deadline 15 Dec 2025 | 3 articles | Viewed by 5165 | Submission Open

Keywords: endometrial cancer; Lynch syndrome; oncology; sentinel lymph node; uterine cancer; molecular classification

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Outcome Analysis and Predictive Insights in Soft Tissue Sarcomas: leveraging Clinical Data and Integrating Modelling

edited by

Bruno Fuchs

submission deadline 15 Dec 2025 | 2 articles | Viewed by 3736 | Submission Open

Keywords: bone sarcomas; soft tissue sarcomas; outcome analysis; predictive modelling; prognostic biomarkers; therapeutic impact; clinical data integration; survivorship prediction; patient trajectories; sarcoma management

(This special issue belongs to the Section Methods and Technologies Development)

Incorporating DNA Damage Response (DDR) Mechanisms in Cancer Systems: 2nd Edition

edited by

Alexandros Georgakilas

submission deadline 15 Dec 2025 | 1 articles | Viewed by 3042 | Submission Open

Keywords: complex DNA damage; methodologies for detection of DNA damage; DNA damage response (DDR) and repair; biological effects of radiation stress; oxidative stress; and replication stress; DDR and immune response; genomic instability; aging; bioinformatics and systems biology; machine learning and artificial intelligence; cancer survival and therapeutics; 3D bioprinting of cells and tissues

(This special issue belongs to the Section Molecular Cancer Biology)

Multicellular 3D Models of Cancer

edited by

Marilena Loizidou

and

Eirini Velliou

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2885 | Submission Open

Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Genomics and Molecular Diagnostics in Gynecological Pathology

edited by

Maria Olinca

and

Radu Pirlog

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2591 | Submission Open

Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Signaling Pathways in Breast Cancer: 2nd Edition

edited by

Sharad S. Singhal

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2183 | Submission Open

Keywords: angiogenesis; apoptosis; breast cancer metastasis; breast cancer stem cells; cancer invasion; chemoprevention; epithelial-to-mesenchymal transition; ERα /ERBB2/HER2/NFκ B/Notch3/TGFβ signaling; mammary carcinogenesis; mitochondrial dynamics; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Thoracic Neuroendocrine Tumors and the Role of Emerging Therapies

edited by

and

submission deadline 20 Dec 2025 | 4 articles | Viewed by 12428 | Submission Open

Keywords: thoracic neuroendocrine tumors; lung NETs; low-grade typical carcinoids; TCs; intermediate-grade atypical carcinoids; ACs; high-grade large cell neuroendocrine carcinoma LCNEC; small cell lung carcinoma (SCLC) neuroendocrine carcinoma

(This special issue belongs to the Section Cancer Therapy)

Optimizing Surgical Procedures and Outcomes in Renal Cancer

edited by

Maciej Salagierski

and Piotr Kania

submission deadline 20 Dec 2025 | 6 articles | Viewed by 9098 | Submission Open

Keywords: renal cancer surgery; optimizing outcomes; minimally invasive techniques; surgical innovations; multidisciplinary approaches

(This special issue belongs to the Section Clinical Research of Cancer)

Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment

edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and

Michał Ciebiera

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5899 | Submission Open

Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition

edited by

Christian Sebesta

and

Harald Rosen

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4316 | Submission Open

Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Histopathology and Pathogenesis of Skin Cancer

edited by

Carlos Torres-Cabala

and

Alessio Giubellino

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3518 | Submission Open

Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Insights into the Pathogenesis of Cutaneous T-Cell Lymphoma and the Impact of These Potential Biomarkers on Future Diagnosis, Prognosis and Treatment

edited by Sean Whittaker

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2923 | Submission Open

Keywords: primary cutaneous T-cell lymphomas; CTCL; pathogenesis; biomarkers; diagnosis; prognosis; treatment

(This special issue belongs to the Section Cancer Biomarkers)

A Deeper Dive into Signaling Pathways in Cancers (2nd Edition)

edited by

Mari Masuda

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1776 | Submission Open

Keywords: signaling pathways; cancer; drug resistance; tumor microenvironment; molecularly targeted drug; epigenetic regulation; reverse-phase protein array

(This special issue belongs to the Section Tumor Microenvironment)

The Impact of Minimally Invasive Surgery on Gynecologic Cancers

edited by

Gabriel Levin

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1116 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy

(This special issue belongs to the Section Cancer Therapy)

IBD-Associated Cancer

edited by Takayuki Ogino

submission deadline 20 Dec 2025 | Viewed by 299 | Submission Open

Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Translational Cancer Research in Multiple Myeloma, with a Focus on Immune Therapies and Novel Agents – “The Bench Behind the Bedside”

edited by Paul G. Richardson,

Constantine S. Mitsiades

and Shonali Midha

submission deadline 20 Dec 2025 | Viewed by 178 | Submission Open

Keywords: multiple myeloma; immune microenvironment; signaling pathways; therapeutic targets; immune effector cell therapies; monoclonal antibodies; targeted agents; mechanisms of action; resistance mechanisms; treatment

(This special issue belongs to the Section Cancer Therapy)

Metastasis Associated Long Noncoding RNAs in Cancer Research

edited by

Kouhei Sakurai

submission deadline 21 Dec 2025 | Viewed by 343 | Submission Open

Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature

(This special issue belongs to the Section Cancer Metastasis)

Tumor Immune Microenvironment in Gastric Cancers

edited by

Chandrani Sarkar

and

Debanjan Chakroborty

submission deadline 25 Dec 2025 | 4 articles | Viewed by 17453 | Submission Open

Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages

(This special issue belongs to the Section Tumor Microenvironment)

Study on Epidemiology of Childhood Cancer

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 25 Dec 2025 | 5 articles | Viewed by 13820 | Submission Open

Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Ovarian Cancer Research and Treatment: 2nd Edition

edited by

Maria Barbolina

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6745 | Submission Open

Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets

(This special issue belongs to the Section Cancer Therapy)

Epigenetics in Endocrine-Related Cancer

edited by Jennie N Jeyapalan

submission deadline 25 Dec 2025 | 2 articles | Viewed by 3990 | Submission Open

Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Blood Cancers: How We Define Success

edited by

Stefano Molica

and

David Allsup

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2775 | Submission Open

Keywords: blood cancers; research-driven advancements; cure rates; novel agents

(This special issue belongs to the Section Cancer Therapy)

Measurable Residual Disease in Cancer: 2nd Edition

edited by Krzysztof Jamroziak and

Bartosz Pula

submission deadline 25 Dec 2025 | Viewed by 198 | Submission Open

Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques

(This special issue belongs to the Section Cancer Drug Development)

Predictive Biomarkers for Lung Cancer

edited by Ole Hilberg

submission deadline 30 Dec 2025 | 10 articles | Viewed by 26366 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers

edited by

Edgar Dahl

submission deadline 30 Dec 2025 | 2 articles | Viewed by 6055 | Submission Open

Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics

(This special issue belongs to the Section Tumor Microenvironment)

Understanding the Complexities of Anticancer Drugs Resistance

edited by

Mariarosaria Conte

and

Nunzio Del Gaudio

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4802 | Submission Open

(This special issue belongs to the Section Cancer Drug Development)

Transcription Factors in Breast Cancer

edited by

Sarah Walker

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4064 | Submission Open

Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms

edited by Francesco Santullo and Agostino Maria De Rose

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3297 | Submission Open

Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Palliative Radiotherapy for Cancer

edited by Rebecca Wong

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2804 | Submission Open

Keywords: symptom relief; symptom control; radiation medicine; radiotheranostics; theranostics; external beam radiotherapy; palliation; oligometastases; oligoprogression; systematic reviews and meta-analyses; patient reported outcomes; abscopal effect; combined modality; education; clinical practice

(This special issue belongs to the Section Cancer Therapy)

Combination Therapy in Geriatric Population with Cancer (2nd Edition)

edited by

Lore Decoster

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2351 | Submission Open

Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Thoracic Cancers

edited by

Monica Casiraghi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 703 | Submission Open

Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma

(This special issue belongs to the Section Clinical Research of Cancer)

Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer

edited by

Subburaj Ilangumaran

and

Seung-Hwan Lee

submission deadline 30 Dec 2025 | Viewed by 591 | Submission Open

Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Insights from the Editorial Board Member

edited by

Carlos S. Moreno

submission deadline 31 Dec 2025 | 52 articles | Viewed by 129002 | Submission Open

Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics

Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management

edited by