The Impact of Treatment Resistance in Prostate Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (10 December 2025) | Viewed by 2239
Special Issue Editor
Special Issue Information
Dear Colleagues,
The past decade of genomic profiling has proven that prostate cancer (PCa) is a heterogeneous disease, and the cellular and extracellular factors responsible for prostate cancer progression and therapeutic resistance remain unclear. Primary PCa is driven by activation of the androgen receptor (AR), and most patients initially respond well to androgen deprivation therapy (ADT). However, almost all patients will progress to castration-resistant prostate cancer (CRCP), which has no effective treatments. The therapeutic landscape for prostate cancer has dramatically changed due to advances in ADT, radiation, and the introduction of immunotherapy. While these treatments have shown success and improved patient outcomes, they are not curative and select for more aggressive, highly resistant forms of prostate cancer. Therefore, there is a need for a complete understanding of the cellular and tumor microenvironmental factors that facilitate therapeutic resistance, not just the androgen receptor (AR)’s signaling cascade, to identify new drug targets. The objective of this collection is to highlight the latest insights into PCa progression, the mechanisms of drug resistance, and new approaches to targeted therapy.
Dr. Noel Andrew Warfel
Guest Editor
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Keywords
- prostate cancer
- treatment resistance
- progression
- drug target
- targeted therapy
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