Prostate Cancer Metastasis—Diagnosis and Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 12 December 2025 | Viewed by 246

Special Issue Editor


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Guest Editor
University of Tuebingen Hospital, 72076 Tuebingen, Germany
Interests: urology; bladder cancer; prostate cancer

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to share the latest developments in the detection of metastasis in advanced prostate cancer. This may be an early event after primary curative treatment, the early detection of hormone-sensitive metastatic disease—whether it is oligometastatic or extensively metastatic—or the various stages of castration-resistant prostate cancer. There may be exclusive treatment options for non-metastatic CRPC and CRPC after one or several previous lines of treatment. Recent developments also include biomarker-based treatment, which predicts the applicability and prognosis of certain treatments. Last but not least, the recent addition of novel hormone treatments, chemotherapy, PSMA ligands, and genetic-based treatment modalities has led to the question of optimal sequences. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Arnulf Stenzl
Guest Editor

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Keywords

  • prostate cancer
  • metastasis
  • hormone-sensitive
  • castration-resistant prostate cancer
  • imaging
  • PSMA
  • ligand therapy
  • sequence
  • oligometastatic
  • biomarker

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Published Papers (1 paper)

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Research

13 pages, 1876 KB  
Article
Prognostic Value of Bone Metastases by Extent of Disease and Lung Metastases in High-Volume Castration-Sensitive Prostate Cancer: A Retrospective Study
by Dai Koguchi, Hideyasu Tsumura, Ken-ichi Tabata, Shuhei Hirano, Soichiro Shimura, Takefumi Satoh, Masaomi Ikeda, Daisuke Ishii and Kazumasa Matsumoto
Cancers 2025, 17(20), 3306; https://doi.org/10.3390/cancers17203306 - 13 Oct 2025
Abstract
Backgrounds: High-volume (HV) metastatic castration-sensitive prostate cancer (mCSPC) is an aggressive disease. Despite this, we aimed to assess the metastatic patterns associated with a favorable prognosis in HV disease with bone metastasis (BM), including BM’s coexistence with lung metastasis (LM). Methods: We retrospectively [...] Read more.
Backgrounds: High-volume (HV) metastatic castration-sensitive prostate cancer (mCSPC) is an aggressive disease. Despite this, we aimed to assess the metastatic patterns associated with a favorable prognosis in HV disease with bone metastasis (BM), including BM’s coexistence with lung metastasis (LM). Methods: We retrospectively analyzed 379 patients with synchronous mCSPC. They were categorized using the CHAARTED criteria as low-volume (LV) or HV with BM, classified based on extent of the disease from 1 to 4 (HV-EOD1–4) with or without LM. Multivariate Cox models for overall survival and castration-resistance-free survival assessed the prognostic values of HV-EOD1–4 compared with LV disease and the presence of LM. Site-specific radiographic progression at the time of castration-resistant prostate diagnosis was assessed in patients with BM and LM. Results: Multivariate analyses for overall survival showed no prognostic value of HV-EOD1 (hazard ratio [HR] 0.90; 95% confidence interval [CI] 0.43–1.85; p = 0.77), HV-EOD2 (HR 1.17; 95% CI 0.69–1.99; p = 0.57), and LM (HR 1.29; 95% CI 0.80–2.07; p = 0.29). In the analyses, HV-EOD ≤ 2 and LM did not influence castration resistance-free survival. LM showed a significantly lower incidence of radiographic progression to castration-resistant prostate cancer than BM (6.0% vs. 29.9%, p < 0.001). Conclusions: This study indicates the prognostic heterogeneity of HV disease considering BM and LM. These findings may aid in determining the treatment intensity for mCSPC. Full article
(This article belongs to the Special Issue Prostate Cancer Metastasis—Diagnosis and Treatment)
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