Advances in Ovarian Cancer Research and Treatment

Dear Colleagues,

Metastatic, chemotherapy-resistant, recurrent epithelial ovarian carcinoma remains to be one of the deadliest malignancies affecting women worldwide. It is a complex disease that is thought to arise from multiple cell types within the female reproductive tract. Several distinct histotypes of epithelial ovarian carcinoma are recognized, with the high-grade serous form being the most predominant and deadliest. High-grade serous ovarian carcinoma disseminates mainly transcoelomically, and patients succumb to the metastases that form within the peritoneal cavity. A better understanding of the biology of these metastases and their response to treatments from the perspective of the microenvironment at the organ sites within the peritoneal cavity and the cancer cells themselves could help in devising rational strategies for preventing or blocking recurrences. This Special Issue will highlight recent advances in the treatment of this deadly disease as well as in research into the mechanisms of its metastasis and chemotherapy resistance.

Dr. Maria Barbolina
Guest Editor

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