Hypoxia and Cancer: From Bench to Bedside
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 33180
Special Issue Editors
Interests: pharmacokinetics; natural compounds; anticancer agents; drug–drug interactions; cancer biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hypoxia has been established as a feature of most cancers, playing a key role in cancer progression, angiogenesis, metastasis, and resistance to therapy. Targeting tumor hypoxia as a promising strategy for cancer therapy has therefore generated keen interest in recent years.
Tumor hypoxia is a result of oxygen deprivation to the tissue as rapid tumor growth outstrips its oxygen supply. Research surrounding hypoxia in cancer points to its ability to modulate multiple pathways in tumor survival and metastasis, including its roles in inducing pro-survival gene expression changes, angiogenesis, epithelial-to-mesenchymal transition, invasiveness, and metabolic switches (the Warburg effect), as well as its contribution to the suppression of immune reactivity and DNA repair pathways. Furthermore, it is also recognized that hypoxia contributes to chemoresistance, thereby posing a significant obstacle in cancer therapy. Thus, studying key pathways involved in tumor hypoxia could provide much needed insight into cancer treatment.
In this Special Issue, recent advancements in research on tumor hypoxia will be highlighted. The scope of this Special Issue includes studies ranging from the influence of hypoxia on various hallmarks of cancer, to the use of pharmacological inhibitors to suppress hypoxia-mediated oncogenic pathways in cancer therapy. More importantly, well-controlled clinical investigations are urgently needed to accelerate translational research and fuel the transition of pertinent discoveries in preclinical studies to tangible applications in clinical settings.
Dr. Lingzhi Wang
Dr. Qingyu Zhou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hypoxia
- HIF-1
- tumor microenvironment
- tumor metastasis
- Warburg effect
- cancer therapeutics
- drug resistance
- radiotherapy resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.