Hyperthermia in Cancer

Dear Colleagues,

Hyperthermia (i.e., heating of tumor tissue to temperatures of 40-45°C) is applied to enhance the effect of radiotherapy and chemotherapy in treatment of, e.g., (recurrent) breast cancer, cervical carcinoma, head and neck cancer, melanoma, and soft tissue sarcoma. Adding hyperthermia yields a significant improvement in tumour response, without increasing toxicity to normal tissues. Hyperthermia has multiple working mechanisms, including the inhibition of DNA-damage repair, changes in perfusion, re-oxygenation, effects on macromolecular delivery, the induction of heat shock response, and immunological stimulation. Ongoing research to further optimize the clinical application of hyperthermia and improve patient outcome is multidisciplinary and includes biology, physics, and clinical research. In this Special Issue, we welcome manuscripts that provide relevant information to advance our understanding in different areas related to hyperthermia, including biological mechanisms; advanced local drug delivery (e.g., using nanoparticles or thermos-sensitive liposomes); heat stress and cancer immune therapy; magnetic particle imaging and magnetic fluid hyperthermia; photothermal therapies, including nanoparticle-mediated photothermal treatments; combination with other agents (e.g., PARP-inhibitors or HSP-90 inhibitors); clinical investigations; advances in thermal simulations and hyperthermia treatment planning; imaging-guided treatment planning and delivery; thermal dosimetry; and biological modelling.

Dr. H. Petra Kok
Dr. Robert Ivkov
Dr. Hans Crezee
Guest Editors

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