Glioblastoma: State of the Art and Future Perspectives
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 269821
Special Issue Editors
2. German Translational Cancer Consortium (DKTK), DKFZ Partner Site, 72072 Tubingen, Germany
3. Cluster of Excellence iFIT (EXC 2180) “Image Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University, 72072 Tubingen, Germany
Interests: tumors of the nervous system; acquired resistance to therapy; tumor-associated microenvironment; experimental glioma models; early phase clinical trials
Interests: neuro-oncology; glioblastoma; meningioma; oncolytic virus; herpes simplex virus; gene therapy
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Special Issue Information
Dear Colleagues,
Glioblastoma is one of the most common types of primary cancer in the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the entry of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs.
Here, we aim at updating researchers and clinicians to provide a systemic view on glioblastoma by highlighting the progress made in basic, preclinical and clinical research and outlining future challenges. To this end, we welcome articles on basic, preclinical and clinical research in glioblastoma. In addition, we will present invited review articles on the topics of neurosurgical approaches, neuropathology and genetics, preclinical research and mouse models of glioblastoma, imaging, radiation therapy and tumor-treating fields, alkylating chemotherapy, immunotherapy, investigational therapies and precision oncology trials in glioblastoma.
Prof. Dr. Ghazaleh TabatabaiDr. Hiroaki Wakimoto
Guest Editors
Manuscript Submission Information
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Keywords
- neurosurgical approaches
- neuropathology and genetics
- preclinical research in glioblastoma
- mouse models of glioblastoma
- imaging, radiation therapy of glioblastoma
- tumor-treating fields
- alkylating chemotherapy
- immunotherapy
- investigational therapies
- precision oncology trials
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