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Open AccessReview

Treatment of Glioblastoma (GBM) with the Addition of Tumor-Treating Fields (TTF): A Review

1
Department of Radiation Oncology, The Ohio State University, Columbus, OH 43210, USA
2
Department of Neuro-Oncology, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(2), 174; https://doi.org/10.3390/cancers11020174
Received: 14 January 2019 / Revised: 29 January 2019 / Accepted: 31 January 2019 / Published: 2 February 2019
(This article belongs to the Special Issue Glioblastoma: State of the Art and Future Perspectives)
Glioblastoma (GBM) is the most common primary brain tumor. Despite aggressive treatment, GBM almost always recurs. The current standard-of-care for treatment of newly diagnosed GBM has remained relatively unchanged since 2005: maximal safe resection followed by concomitant chemoradiation (CRT) with temozolomide (TMZ), and subsequent adjuvant TMZ. In 2011, the first-generation tumor treating fields (TTF) device, known at the time as the NovoTTF-100A System (renamed Optune), was approved by the Food and Drug Administration (FDA) for treatment of recurrent GBM. The TTF device was subsequently approved as an adjuvant therapy for newly-diagnosed GBM in 2015. The following is a review of the TTF device, including evidence supporting its use and limitations. View Full-Text
Keywords: glioblastoma; GBM; tumor treating fields; TTF glioblastoma; GBM; tumor treating fields; TTF
MDPI and ACS Style

Fabian, D.; Guillermo Prieto Eibl, M.P.; Alnahhas, I.; Sebastian, N.; Giglio, P.; Puduvalli, V.; Gonzalez, J.; Palmer, J.D. Treatment of Glioblastoma (GBM) with the Addition of Tumor-Treating Fields (TTF): A Review. Cancers 2019, 11, 174.

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