Next Article in Journal
A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer
Next Article in Special Issue
Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients
Previous Article in Journal
Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting
Previous Article in Special Issue
PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Cancers 2019, 11(2), 146; https://doi.org/10.3390/cancers11020146

Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma

National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 30 December 2018 / Revised: 21 January 2019 / Accepted: 24 January 2019 / Published: 26 January 2019
(This article belongs to the Special Issue Glioblastoma: State of the Art and Future Perspectives)
Full-Text   |   PDF [1077 KB, uploaded 26 January 2019]   |  
  |   Review Reports

Abstract

Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review, we discuss the potential to target cholesterol metabolism as a new strategy for treating glioblastomas. Twenty percent of cholesterol in the body is in the brain, yet the brain is unique among organs in that it has no access to dietary cholesterol and must synthesize it de novo. This suggests that therapies targeting cholesterol synthesis in brain tumors might render their effects without compromising cell viability in other organs. We will describe cholesterol synthesis and homeostatic feedback pathways in normal brain and brain tumors, as well as various strategies for targeting these pathways for therapeutic intervention. View Full-Text
Keywords: glioblastoma; cholesterol; liver X receptor (LXR); brain; liver; metabolism; blood–brain barrier; low-density lipoprotein receptor (LDLR); sterol regulatory element binding protein (SREBP) glioblastoma; cholesterol; liver X receptor (LXR); brain; liver; metabolism; blood–brain barrier; low-density lipoprotein receptor (LDLR); sterol regulatory element binding protein (SREBP)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ahmad, F.; Sun, Q.; Patel, D.; Stommel, J.M. Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma. Cancers 2019, 11, 146.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top