EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma
AbstractThe EphA3 receptor has recently emerged as a functional tumour-specific therapeutic target in glioblastoma (GBM). EphA3 is significantly elevated in recurrent disease, is most highly expressed on glioma stem cells (GSCs), and has a functional role in maintaining self-renewal and tumourigenesis. An unlabelled EphA3-targeting therapeutic antibody is currently under clinical assessment in recurrent GBM patients. In this study, we assessed the efficacy of EphA3 antibody drug conjugate (ADC) and radioimmunotherapy (RIT) approaches using orthotopic animal xenograft models. Brain uptake studies, using positron emission tomography/computed tomography (PET/CT) imaging, show EphA3 antibodies are effectively delivered across the blood-tumour barrier and accumulate at the tumour site with no observed normal brain reactivity. A robust anti-tumour response, with no toxicity, was observed using EphA3, ADC, and RIT approaches, leading to a significant increase in overall survival. Our current research provides evidence that GBM patients may benefit from pay-loaded EphA3 antibody therapies. View Full-Text
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Offenhäuser, C.; Al-Ejeh, F.; Puttick, S.; Ensbey, K.S.; Bruce, Z.C.; Jamieson, P.R.; Smith, F.M.; Stringer, B.W.; Carrington, B.; Fuchs, A.V.; Bell, C.A.; Jeffree, R.; Rose, S.; Thurecht, K.J.; Boyd, A.W.; Day, B.W. EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma. Cancers 2018, 10, 519.
Offenhäuser C, Al-Ejeh F, Puttick S, Ensbey KS, Bruce ZC, Jamieson PR, Smith FM, Stringer BW, Carrington B, Fuchs AV, Bell CA, Jeffree R, Rose S, Thurecht KJ, Boyd AW, Day BW. EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma. Cancers. 2018; 10(12):519.Chicago/Turabian Style
Offenhäuser, Carolin; Al-Ejeh, Fares; Puttick, Simon; Ensbey, Kathleen S.; Bruce, Zara C.; Jamieson, Paul R.; Smith, Fiona M.; Stringer, Brett W.; Carrington, Benjamin; Fuchs, Adrian V.; Bell, Craig A.; Jeffree, Rosalind; Rose, Stephen; Thurecht, Kristofer J.; Boyd, Andrew W.; Day, Bryan W. 2018. "EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma." Cancers 10, no. 12: 519.
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