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Nitric Oxide Antagonism to Anti-Glioblastoma Photodynamic Therapy: Mitigation by Inhibitors of Nitric Oxide Generation

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
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Author to whom correspondence should be addressed.
Cancers 2019, 11(2), 231; https://doi.org/10.3390/cancers11020231
Received: 17 December 2018 / Revised: 25 January 2019 / Accepted: 9 February 2019 / Published: 15 February 2019
(This article belongs to the Special Issue Glioblastoma: State of the Art and Future Perspectives)
Many studies have shown that low flux nitric oxide (NO) produced by inducible NO synthase (iNOS/NOS2) in various tumors, including glioblastomas, can promote angiogenesis, cell proliferation, and migration/invasion. Minimally invasive, site-specific photodynamic therapy (PDT) is a highly promising anti-glioblastoma modality. Recent research in the authors’ laboratory has revealed that iNOS-derived NO in glioblastoma cells elicits resistance to 5-aminolevulinic acid (ALA)-based PDT, and moreover endows PDT-surviving cells with greater proliferation and migration/invasion aggressiveness. In this contribution, we discuss iNOS/NO antagonism to glioblastoma PDT and how this can be overcome by judicious use of pharmacologic inhibitors of iNOS activity or transcription. View Full-Text
Keywords: nitric oxide (NO); inducible nitric oxide synthase (iNOS); photodynamic therapy (PDT); glioblastoma PDT; NO-mediated PDT resistance nitric oxide (NO); inducible nitric oxide synthase (iNOS); photodynamic therapy (PDT); glioblastoma PDT; NO-mediated PDT resistance
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Fahey, J.M.; Girotti, A.W. Nitric Oxide Antagonism to Anti-Glioblastoma Photodynamic Therapy: Mitigation by Inhibitors of Nitric Oxide Generation. Cancers 2019, 11, 231.

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