Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Current Treatment Strategy of Sarcomas submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open
Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target
(This special issue belongs to the Section Molecular Medicine)
Structural and Functional Insights into Metalloantibiotics
edited by
submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open
Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance
(This special issue belongs to the Section Enzymology)
Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment
edited by Eleni E. Mylona and
submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open
Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies
Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease
edited by
submission deadline 1 May 2026 | Viewed by 120 | Submission Open
Keywords: diabetic kidney disease; pathogenesis; novel biomarkers; metabolic memory; SGLT2 inhibitors; fibrotic pathways; epigenetic modification; multi-target pharmacotherapy
Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting
edited by Amiya Kumar Patra
submission deadline 3 May 2026 | 2 articles | Viewed by 854 | Submission Open
Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders
(This special issue belongs to the Section Molecular Biology)
Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies submission deadline 10 May 2026 | Viewed by 72 | Submission Open
Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 15 May 2026 | 7 articles | Viewed by 15369 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems submission deadline 15 May 2026 | Viewed by 88 | Submission Open
Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets submission deadline 15 May 2026 | Viewed by 64 | Submission Open
Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing
Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies
edited by and
submission deadline 16 May 2026 | Viewed by 63 | Submission Open
Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor
(This special issue belongs to the Section Biological Factors)
Notch and Its Regulation in Health and Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 880 | Submission Open
Keywords: Notch; signalling; development; diseases
(This special issue belongs to the Section Molecular Medicine)
Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications
edited by Li Fan
submission deadline 23 May 2026 | Viewed by 112 | Submission Open
Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators
edited by
submission deadline 23 May 2026 | Viewed by 50 | Submission Open
Keywords: protein– protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by and
submission deadline 31 May 2026 | 3 articles | Viewed by 9877 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity
(This special issue belongs to the Section Molecular Medicine)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 6576 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 5542 | Submission Open
Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in RNA Editing and Modification submission deadline 31 May 2026 | 2 articles | Viewed by 4367 | Submission Open
Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advancing Innovations in Biomedical Research for Translational Applications
edited by Jianjie Ma, Ki Ho Park and
submission deadline 31 May 2026 | 3 articles | Viewed by 3872 | Submission Open
Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission
(This special issue belongs to the Section Molecular Medicine)
Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights
edited by and Brandi M. Wynne
submission deadline 31 May 2026 | 2 articles | Viewed by 3258 | Submission Open
Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release
(This special issue belongs to the Section Cellular Biochemistry)
Molecular and Cellular Mechanisms in Skin Disorders
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 2985 | Submission Open
Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ
(This special issue belongs to the Section Molecular Biology)
Protein Biophysics submission deadline 31 May 2026 | 2 articles | Viewed by 2337 | Submission Open
Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Cutting-Edge Perspectives on Protein and Enzyme Engineering
edited by Haishan Qi and Haoran Yu
submission deadline 31 May 2026 | 1 articles | Viewed by 1677 | Submission Open
Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advances in Metabolomics in Health and Disease
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics
(This special issue belongs to the Section Molecular Medicine)
DNA Damage Repair and Cancer Therapeutics
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1256 | Submission Open
Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics submission deadline 31 May 2026 | 1 articles | Viewed by 1201 | Submission Open
Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1029 | Submission Open
Keywords: metabolic dysfunction; molecular mechanisms; therapeutic strategies; genomics; genetic epidemiology; comorbidities; biomarkers
Advances in Microbial CRISPR Editing
edited by and Rongming Liu
submission deadline 31 May 2026 | 1 articles | Viewed by 886 | Submission Open
Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems
(This special issue belongs to the Section Molecular Biology)
Advances in Membrane Proteins: From Structure to Function and Molecular Engineering
edited by and Renhong Yan
submission deadline 31 May 2026 | 1 articles | Viewed by 621 | Submission Open
Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 569 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Pediatric Epilepsy: Insights from Genetics to Mechanisms
edited by Denise Drongitis and
submission deadline 31 May 2026 | Viewed by 425 | Submission Open
Keywords: integrative omics; organoid models; brain development; PE-related pathways; innovative therapeutic approaches
(This special issue belongs to the Section Molecular Genetics)
Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke
edited by
submission deadline 31 May 2026 | Viewed by 368 | Submission Open
Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathways Controlling Platelet and Megakaryocyte Activity
edited by Ana Kasirer-Friede and Deepa Gautam
submission deadline 31 May 2026 | Viewed by 210 | Submission Open
Keywords: platelet; megakaryocyte; signaling; omics; immune
(This special issue belongs to the Section Molecular Biology)
Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition submission deadline 31 May 2026 | Viewed by 153 | Submission Open
Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies
(This special issue belongs to the Section Molecular Biology)
The Role of Amyloid in Neurological Disorders: 2nd Edition
edited by and Tamara Berno
submission deadline 31 May 2026 | Viewed by 133 | Submission Open
Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Symbiotic Systems and Viral Diversity: From Marine Organisms to Human Pathogenesis submission deadline 31 May 2026 | Viewed by 109 | Submission Open
Keywords: viral diversity; virome; symbiosis; genomics; pathogenesis; metagenomics; sequencing
Artificial Intelligence in Structural Biology and Drug Discovery
edited by Kyle Biggar
submission deadline 31 May 2026 | Viewed by 95 | Submission Open
Keywords: protein structure prediction; drug discovery; molecular docking; experimental validation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders submission deadline 31 May 2026 | 1 articles | Viewed by 65 | Submission Open
Keywords: systemic inflammation; neuroinflammation diseases; neurodegenerative diseases; mental disorders
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms of Viral Infections—2nd Edition submission deadline 31 May 2026 | Viewed by 63 | Submission Open
Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence
(This special issue belongs to the Section Molecular Biology)
Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights submission deadline 31 May 2026 | Viewed by 59 | Submission Open
Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Molecular Medicine)
Molecular Diagnostics and Targeted Therapies for Breast and Prostate Cancers
edited by , Ekaterina Bezverkhniaia and Panagiotis Kanellopoulos
submission deadline 31 May 2026 | Viewed by 53 | Submission Open
Keywords: molecular imaging; targeted therapy; prostate cancer; breast cancer; theranostics
(This special issue belongs to the Section Biological Factors)
Molecular Engineering and Applications of Protein Cages and Cavities
edited by
submission deadline 31 May 2026 | Viewed by 53 | Submission Open
Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal; materials science; and analytical applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advances and Emerging Strategies in Gene Therapy
edited by Xin Chen
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: AAV; gene-editing; base editing; prime editing; RNA editing; lipid nanoparticles; liposomes; exosomes; tRNA therapy; small activating RNAs
(This special issue belongs to the Section Molecular Medicine)
Genetic Variations and Gene Expression in Disease
edited by
submission deadline 31 May 2026 | Viewed by 31 | Submission Open
Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis
(This special issue belongs to the Section Molecular Biology)
Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies
edited by
submission deadline 31 May 2026 | Viewed by 25 | Submission Open
Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis
(This special issue belongs to the Section Molecular Genetics)
Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy
edited by
submission deadline 31 May 2026 | Viewed by 19 | Submission Open
Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms
(This special issue belongs to the Section Biological Factors)
Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications
edited by and Anthea Miller
submission deadline 31 May 2026 | Viewed by 11 | Submission Open
Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)
(This special issue belongs to the Section Molecular Medicine)
Advances in Cardiometabolic Health, 2nd Edition
edited by Pamela Senesi and
submission deadline 31 May 2026 | Viewed by 9 | Submission Open
Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine
(This special issue belongs to the Section Cellular Biochemistry)
Nitric Oxide and Reactive Species in Plant Physiology and Pathology
edited by
submission deadline 31 May 2026 | Viewed by 8 | Submission Open
Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation
(This special issue belongs to the Section Biological Factors)
Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD
edited by Weber Andre Alberto
submission deadline 31 May 2026 | Viewed by 3 | Submission Open
Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress
(This special issue belongs to the Section Molecular Medicine)
Skin Diseases: Molecular Pathogenesis and Therapeutic Approaches
edited by Georgios Gaitanis, and Achilleas Floudas
submission deadline 31 May 2026 | Viewed by 2 | Submission Open
Keywords: skin; pathophysiology; immunology; biochemistry; omics
(This special issue belongs to the Section Molecular Medicine)
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