Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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When Molecules Meet Light: Advances in Photodynamic Therapy and Imaging submission deadline 28 Feb 2027 | Viewed by 89 | Submission Open
Keywords: molecules; light; photodynamic therapy; imaging
(This special issue belongs to the Section Molecular Medicine)
Advancing Innovations in Biomedical Research for Translational Applications: 2nd Edition
edited by Jianjie Ma and
submission deadline 28 Feb 2027 | Viewed by 81 | Submission Open
Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission
(This special issue belongs to the Section Molecular Medicine)
Cytogenetics, Molecular Diagnostics and Biomarkers in Hematologic Malignancies
edited by Changqing Xia and
submission deadline 28 Feb 2027 | Viewed by 66 | Submission Open
Keywords: cytogenomics; cytogenetics; molecular biomarkers; leukemia; lymphoma; multiple myeloma; diagnosis; prognosis; targeted therapies; precision medicine
(This special issue belongs to the Section Molecular Biomarkers)
NFAT Transcription Factors in Immunity and Disease : A Themed Issue in Honor of Prof. Edgar Serfling
edited by
submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open
Keywords: NFAT transcription factors; T-cell activation; immune regulation; transcriptional control; inflammation; cancer immunology; signal transduction; immunotherapy; calcineurin signaling; transplantation; transplant immunology; immunosuppression; targeted therapy
(This special issue belongs to the Section Cellular Biochemistry)
White Matter Injury and Neurovascular Dysfunction in Neurological Disorders
edited by
submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: white matter injury, remyelination, neurovascular dysfunction; neurovascular unit; ischemic stroke; neurodegeneration; blood–brain barrier; cellular mechanisms; molecular pathways; vascular cognitive impairment; Alzheimer's disease
(This special issue belongs to the Section Molecular Medicine)
Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications
edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros
submission deadline 1 Mar 2027 | Viewed by 318 | Submission Open
Keywords: botanical bioactives; by-products; natural food additives; green extraction
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Impact of Obesity, Ethnicity, and Genetic Susceptibility on Beta Cell Function
edited by Joseph Proietto
submission deadline 12 Mar 2027 | Viewed by 51 | Submission Open
Keywords: obesity-induced diabetes; beta cell function; diabetes complications; susceptibility; genetics
(This special issue belongs to the Section Biological Factors)
Molecular Mechanisms and Emerging Therapies for Diabetic Cardiomyopathy submission deadline 15 Mar 2027 | Viewed by 76 | Submission Open
Keywords: diabetic cardiomyopathy; diabetes-related cardiac dysfunction; cardiac remodeling; molecular mechanisms; emerging therapies; cardiometabolic disease
(This special issue belongs to the Section Molecular Medicine)
Dynamic Remodeling of the 3D Genome in Development and Diseases
edited by
submission deadline 18 Mar 2027 | Viewed by 45 | Submission Open
Keywords: 3D genome organization; cell fate specification; disease pathogenesis; topologically associating domains (TADs); enhancer–promoter interactions; gene expression regulation
(This special issue belongs to the Section Molecular Reproduction)
Biomarkers in Musculoskeletal and Orthopedic Disorders
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 1351 | Submission Open
Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis
(This special issue belongs to the Section Molecular Biomarkers)
Signal Transduction and Pathway Regulation in Cancer submission deadline 25 Mar 2027 | 5 articles | Viewed by 3983 | Submission Open
Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis
(This special issue belongs to the Section Molecular Biology)
Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition
edited by and
submission deadline 26 Mar 2027 | 2 articles | Viewed by 1396 | Submission Open
Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein–protein interactions; protein–ligand binding; conformational dynamics; molecular docking studies
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Roles of Epigenetics in Plant Defense submission deadline 28 Mar 2027 | Viewed by 19 | Submission Open
Keywords: plant defense; epigenetics; epitranscriptomics; non-coding RNAs; chromatin remodeling; RNA modifications; plant–pathogen interactions; defense priming; CRISPR epigenome editing; genome wide; multi-omics; disease-resistant crops; artificial intelligence (AI); systemic acquired resistance (SAR); induced systemic resistance (ISR); pattern-triggered immunity (PTI); effector-triggered immunity (ETI)
(This special issue belongs to the Section Molecular Genetics)
Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives submission deadline 30 Mar 2027 | 3 articles | Viewed by 3518 | Submission Open
Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise
(This special issue belongs to the Section Biological Factors)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 31 Mar 2027 | 3 articles | Viewed by 4663 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications
edited by and Anthea Miller
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3725 | Submission Open
Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition submission deadline 31 Mar 2027 | 2 articles | Viewed by 3624 | Submission Open
Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering
(This special issue belongs to the Section Enzymology)
Nitric Oxide and Reactive Species in Plant Physiology and Pathology
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3490 | Submission Open
Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation
(This special issue belongs to the Section Biological Factors)
Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors
edited by and
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3096 | Submission Open
Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain
New Insights into Integrins: 2nd Edition
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1724 | Submission Open
Keywords: integrins; growth factors; ligands; allosteric binding; inflammation-induced activation
(This special issue belongs to the Section Biological Factors)
Recent Advances in Structure-Based Inhibitor/Drug Design
edited by and Si‑Ming Liao
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1522 | Submission Open
Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)
Natural Compounds with Biomedical Potential submission deadline 31 Mar 2027 | 1 articles | Viewed by 1441 | Submission Open
Keywords: natural compounds; naturat extracts; drug discovery; antimicrobial activity; antioxidant activity; anticancer activity; anti-inflammatory activity; anti-diabetes activity
(This special issue belongs to the Section Chemical Biology)
Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD
edited by Weber Andre Alberto
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1375 | Submission Open
Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress
(This special issue belongs to the Section Molecular Medicine)
Molecular Genetics of Parasitic Protozoa submission deadline 31 Mar 2027 | 1 articles | Viewed by 1298 | Submission Open
Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health
(This special issue belongs to the Section Molecular Genetics)
Bone Injuries: New Pharmaceutical, Biomaterial and Therapies
edited by Xinlin Yang
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1160 | Submission Open
Keywords: bone regeneration; biomaterials; drug delivery; tissue engineering; stem cell therapy; osteogenesis; bone repair; regenerative medicine
Multifunctional Nanocarriers for Advanced Therapy and Diagnosis
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 950 | Submission Open
Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles
(This special issue belongs to the Section Bio-Engineered Materials)
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 31 Mar 2027 | Viewed by 842 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Proteins Governing Genome Architecture and Gene Expression
edited by and
submission deadline 31 Mar 2027 | 1 articles | Viewed by 798 | Submission Open
Keywords: regulatory proteins; genome architecture; gene regulation; chromatin dynamics; structural mechanisms; functional studies; protein–protein interaction; protein–DNA interaction
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Biology and Therapy of Breast Cancer
edited by
submission deadline 31 Mar 2027 | Viewed by 486 | Submission Open
Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA
Non-Invasive Biomarker Screening in Cancer
edited by and F. G. Pinto
submission deadline 31 Mar 2027 | Viewed by 388 | Submission Open
Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies
(This special issue belongs to the Section Molecular Biomarkers)
Genetic Variations and Gene Expression in Diseases
edited by
submission deadline 31 Mar 2027 | Viewed by 328 | Submission Open
Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis
(This special issue belongs to the Section Molecular Biology)
Emerging Bioactive Compounds from Medicinal Plants
edited by Shiau Pin Tan and
submission deadline 31 Mar 2027 | Viewed by 281 | Submission Open
Keywords: bioactive compounds; medicinal plants; molecular mechanisms; green chemistry; bioassay-guided isolation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Next-Gen Antimicrobials: Discovery, Engineering and Synergistic Approaches
edited by
submission deadline 31 Mar 2027 | Viewed by 218 | Submission Open
Keywords: antimicrobial agents; antimicrobial discovery; antimicrobial engineering; antimicrobial applications; synergistic antimicrobial strategies
(This special issue belongs to the Section Molecular Medicine)
Hormonal Mediated Stress Resistance of Horticultural Crops
edited by and
submission deadline 31 Mar 2027 | Viewed by 97 | Submission Open
Keywords: horticultural crops; phytohormones; abiotic and biotic stress; hormonal crosstalk; signal transduction; transcription factor regulation; crop improvement; postharvest physiology
(This special issue belongs to the Section Molecular Biology)
Advances in Plasma Bioscience and Medicine: 3rd Edition submission deadline 31 Mar 2027 | Viewed by 88 | Submission Open
Keywords: plasma medicine; non-thermal plasma; plasma bioscience; biomolecules; reactive oxygen and nitrogen species; cancer therapy; wound healing and tissue regeneration; computational modeling and simulations; plasma–biomolecule interactions; biomedical applications
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Molecular Insights in Immunogenetics: Structure and Evolution of the Antigen Receptors of the Adaptive Immune Response submission deadline 31 Mar 2027 | Viewed by 84 | Submission Open
Keywords: immunogenetics; immune response; genetic variation; structural interaction; autoimmunity; genomics; transcriptomics; molecular mechanisms
(This special issue belongs to the Section Molecular Genetics)
Mesenchymal Stem Cell Therapy
edited by Feng Dong
submission deadline 31 Mar 2027 | Viewed by 49 | Submission Open
Keywords: cell-free therapy; exosomes; mesenchymal stem cell
(This special issue belongs to the Section Biological Factors)
From Computational Design to Experimental Validation: Integrated Workflows in Drug Discovery submission deadline 3 Apr 2027 | Submission Open
Keywords: computer-aided drug design; computational drug discovery; machine learning; artificial intelligence; experimental validation; molecular modeling; structure-based drug design; ligand-based drug design; virtual screening; molecular docking; molecular dynamics; chemoinformatics; QSAR; molecular property prediction; de novo molecular design; medicinal chemistry; hit identification; lead optimization; drug repurposing; structure–activity relationships
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function
edited by and Tamaki Endoh
submission deadline 30 Apr 2027 | 4 articles | Viewed by 4495 | Submission Open
Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Heterocyclic Compounds: Synthesis, Characterization, and Validation
edited by
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2949 | Submission Open
Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals
(This special issue belongs to the Section Chemical Biology)
Mesenchymal Stromal Cells in Regenerative Medicine and Immune Modulation: Mechanisms, Engineering, and Therapeutic Applications
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 606 | Submission Open
Keywords: mesenchymal stromal cells; immunomodulation; regenerative medicine; tumor microenvironment; cancer immunotherapy; extracellular vesicles; non‑coding RNAs; engineered MSCs; cell–cell communication
(This special issue belongs to the Section Cellular Biochemistry)
Immunohistochemical and Molecular Approaches to Gastrointestinal Disease Characterization submission deadline 30 Apr 2027 | Viewed by 50 | Submission Open
Keywords: gastrointestinal diseases; biomarkers; artificial intelligence; multimodal therapy; immunohistochemistry
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights Into Antibody-Drug Conjugates for Application in Oncology and Beyond submission deadline 30 Apr 2027 | Viewed by 39 | Submission Open
Keywords: antibody–drug conjugates; protein-drug conjugates; small molecule–drug conjugates; targeted delivery; controlled release; cancer research; inflammation; proteases; infectiology
(This special issue belongs to the Section Molecular Medicine)
Microbial Metabolites, Host Responses and Gastrointestinal Diseases
edited by , and Tahrir Alenezi
submission deadline 20 May 2027 | Viewed by 44 | Submission Open
Keywords: gut homeostasis and disease; inflammation; microbiota; metabolites; microbial factors
(This special issue belongs to the Section Molecular Biology)
Protein Biophysics submission deadline 31 May 2027 | 5 articles | Viewed by 9883 | Submission Open
Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein–ligand interactions; protein–protein interactions; protein–nucleic acid interactions; membrane proteins; liquid–liquid phase separation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Molecular Engineering and Applications of Protein Cages and Cavities
edited by
submission deadline 31 May 2027 | Viewed by 344 | Submission Open
Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal, materials science, and analytical applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Decoding Cellular Pathogenesis of Hypertension: Emerging Mechanisms and Therapeutic Targets
edited by Satoru Eguchi and Yuka Terada
submission deadline 31 May 2027 | Viewed by 264 | Submission Open
Keywords: omics; microbiota; signal transduction; epigenetics; cellular mechanisms
(This special issue belongs to the Section Molecular Medicine)
Biomolecules in Colorectal Cancer: From Bench to Bedside
edited by
submission deadline 31 May 2027 | Viewed by 49 | Submission Open
Keywords: colorectal cancer; biomarkers; precision oncology; perioperative biology; translational medicine
(This special issue belongs to the Section Molecular Medicine)
Deciphering Molecular Landscape and Biomarkers of Tumor Progression for Precision Oncology
edited by Claudia Sabato and
submission deadline 31 May 2027 | Viewed by 25 | Submission Open
Keywords: intratumor heterogeneity dynamics; oncogenic signaling networks; EMT-mediated matrix remodeling; metabolic reprogramming pathway; metastatic dissemination; cancer biomarkers; immune evasion signaling; therapeutic resistance; multi-omics profiling; tumor microenvironment
(This special issue belongs to the Section Molecular Medicine)
Molecular and Cellular Mechanism of Gynecologic Malignancies
edited by and Cezary Miedziarek
submission deadline 10 Jun 2027 | Viewed by 6 | Submission Open
Keywords: gynecological neoplasms; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; gestational neoplastic disease; tumor microenvironment; genomics; transcriptome; metabolomics
(This special issue belongs to the Section Molecular Medicine)
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