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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 15 Apr 2026 | 1 articles | Viewed by 3564 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 20 Apr 2026 | 6 articles | Viewed by 21629 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy

edited by

Célia Duarte Cruz

and

José Tiago Costa-Pereira

submission deadline 20 Apr 2026 | Viewed by 85 | Submission Open

Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition

edited by Peng Yao and

Wei Guo

submission deadline 20 Apr 2026 | Viewed by 24 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 25 Apr 2026 | 1 articles | Viewed by 1725 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Apr 2026 | 5 articles | Viewed by 9929 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5327 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Genetics and Epigenetics of Breast Cancer

edited by

Ashakumary Lakshmikuttyamma

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4441 | Submission Open

Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Therapeutic Targets in Leukaemia

edited by

Sabrina Tosi

and

Denise Ragusa

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3976 | Submission Open

Keywords: leukaemia; blood; genetics; genomics; chromosome

(This special issue belongs to the Section Molecular Medicine)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

and

Laura Hamilton

submission deadline 30 Apr 2026 | 5 articles | Viewed by 3882 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3668 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3627 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3475 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2765 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Genetics of Human Disease

edited by

Rais Ahmad Ansari

and Ata Abbas

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1971 | Submission Open

Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication

(This special issue belongs to the Section Molecular Genetics)

Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1861 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1721 | Submission Open

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 30 Apr 2026 | 3 articles | Viewed by 1714 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Homocysteine and H₂S in Health and Disease, 2nd Edition

edited by

Anton Hermann

and

Guzel F. Sitdikova

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1464 | Submission Open

Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation

(This special issue belongs to the Section Chemical Biology)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1398 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1325 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

The Role and Metabolism of Metals in Cancer

edited by

Anna Martina Battaglia

submission deadline 30 Apr 2026 | 1 articles | Viewed by 686 | Submission Open

Keywords: metals; cancer; cancer metabolism

(This special issue belongs to the Section Chemical Biology)

Phytochemicals: Bioactivity in Disease Prevention, Anti-Inflammation, and Animal/Human Health

edited by

Jayasimha Rayalu Daddam

and

Kotha Peddanna

submission deadline 30 Apr 2026 | Viewed by 679 | Submission Open

Keywords: phytochemicals; anti-inflammatory; metabolic health; oxidative stress; gut microbiome; nutrigenomics; animal health; human health; systems biology; AI/ML

(This special issue belongs to the Section Molecular Medicine)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Apr 2026 | 1 articles | Viewed by 619 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Apr 2026 | Viewed by 306 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 30 Apr 2026 | Viewed by 268 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Apr 2026 | Viewed by 265 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Apr 2026 | Viewed by 223 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators

edited by

Danuta Drozdowska

submission deadline 30 Apr 2026 | Viewed by 204 | Submission Open

Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity

(This special issue belongs to the Section Chemical Biology)

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Apr 2026 | Viewed by 191 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

Advances in Antimicrobial Peptides (AMPs)

edited by

Andrea Bosso

submission deadline 30 Apr 2026 | Viewed by 178 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense peptides (HDPs); peptidomimetics; antimicrobial resistance (AMR); membrane interaction; cryptides; immunomodulation; peptide design and synthesis; biofilm inhibition; drug delivery systems

Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications

edited by George Kokotos and

Christiana Mantzourani

submission deadline 30 Apr 2026 | Viewed by 146 | Submission Open

Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Structure-Based Inhibitor/Drug Design

edited by

Guoping Zhou

submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open

Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)

Glycomics in Health, Aging and Disease

edited by

Domenico Garozzo

submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open

Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates

(This special issue belongs to the Section Cellular Biochemistry)

Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function

edited by

Keiko Kawauchi

and Tamaki Endoh

submission deadline 30 Apr 2026 | Viewed by 88 | Submission Open

Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

edited by

Virginia Tancredi

Roberto Bonanni

and

Ida Cariati

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise

(This special issue belongs to the Section Biological Factors)

Lipids and Lipoproteins in Human Health and Disease

edited by

Menno Hoekstra

submission deadline 30 Apr 2026 | Viewed by 71 | Submission Open

Keywords: lipid; lipoprotein; lipophilic molecules

(This special issue belongs to the Section Biological Factors)

Therapeutic Applications of Extracellular Vesicles in Inflammation and Immunoregulation

edited by

Ahmed Abdal Dayem

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: extracellular vesicles; inflammatory diseases; immunomodulation; regenerative therapy; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Signal Transduction and Pathway Regulation in Cancer

edited by

Carmen Cristina Diaconu

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Pathogenesis, and Treatment of Cardiovascular Diseases

edited by

Mahavir Singh

and

Zsuzsa Bagoly

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: cardiovascular diseases; molecular pathogenesis; genomics and metabolomics; AI/ML diagnostics; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

The Immune Response to Severe Trauma

edited by

Jon Hazeldine

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care

(This special issue belongs to the Section Molecular Medicine)

Application of Spectral Analysis in Disease Diagnosis and Treatment

edited by

Entesar Al-Hetlani

and

Igor Lednev

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning

(This special issue belongs to the Section Molecular Medicine)

The Role of Scavenger Receptors in Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: scavenger receptor; CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Biological Factors)

Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies

edited by

Ximena Maria Muresan

and

Ioana Ecaterina Pralea

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy

(This special issue belongs to the Section Molecular Biomarkers)

Pathophysiological Insights into Congenital Myasthenic Syndromes

edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model

(This special issue belongs to the Section Molecular Medicine)

Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders

edited by Katerina Karaivazoglou and