Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment
edited by Eleni E. Mylona and
submission deadline 31 Dec 2026 | Viewed by 610 | Submission Open
Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies
Feature Papers in “Bio-Engineered Materials” Section
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 558 | Submission Open
Keywords: bio-engineered materials; functional biomaterials; biofabrication; hydrogels; biointerfaces; tissue engineering; regenerative medicine; polymers; polysaccharides; proteins
(This special issue belongs to the Section Bio-Engineered Materials)
Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 555 | Submission Open
Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes
(This special issue belongs to the Section Chemical Biology)
Molecular Docking and Dynamics in Drug Discovery
edited by
submission deadline 31 Dec 2026 | Viewed by 555 | Submission Open
Keywords: molecular docking; molecular dynamics (MD); structure-based drug design (SBDD); computational drug discovery; open science
(This special issue belongs to the Section Chemical Biology)
Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders
edited by Katerina Karaivazoglou and
submission deadline 31 Dec 2026 | Viewed by 469 | Submission Open
Keywords: microbiome–gut–brain axis; neurodevelopmental disorders; autism; schizophrenia; intestinal dysbiosis
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Quantum Biology
edited by Daniel R. Kattnig
submission deadline 31 Dec 2026 | Viewed by 447 | Submission Open
Keywords: quantum biology; molecular mechanisms; quantum coherence; quantum entanglement; magnetoreception; quantum cognition; photosynthetic energy transfer; biological qubits; quantum sensing; environment-assisted quantum effects
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications
edited by Weiwei He and Serdal Kirmizialtin
submission deadline 31 Dec 2026 | Viewed by 419 | Submission Open
Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism
Molecular Mechanisms of Viral Infections—2nd Edition submission deadline 31 Dec 2026 | Viewed by 388 | Submission Open
Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence
(This special issue belongs to the Section Molecular Biology)
Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators
edited by
submission deadline 31 Dec 2026 | Viewed by 381 | Submission Open
Keywords: protein–protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Biomolecules in Mycobacterial Pathogenesis, Host–Pathogen Interactions, and Antimicrobial and Therapeutic Approaches
edited by Cinzia Marianelli
submission deadline 31 Dec 2026 | Viewed by 381 | Submission Open
Keywords: mycobacterium; pathogenesis; host–pathogen interaction; antimicrobial action; therapeutic alternatives
(This special issue belongs to the Section Molecular Biology)
The Structure and Function of MHC Class I Molecules in Health and Disease: Implications in Aging and Neuro-Immune Crosstalk submission deadline 31 Dec 2026 | Viewed by 380 | Submission Open
Keywords: classical MHC-I molecules; human leukocyte antigen (HLA) class I; soluble HLA class I; immunological and non-immunological functions; neuro-immune crosstalk; aging and brain cognition
(This special issue belongs to the Section Cellular Biochemistry)
AI-Driven Approaches to Neurodegeneration: From Disease Models to Therapeutic Strategies
edited by , Jianfu Li and Naeyma N. Islam
submission deadline 31 Dec 2026 | Viewed by 372 | Submission Open
Keywords: artificial intelligence (AI); neurodegeneration; disease modeling; therapeutic discovery; machine learning in biomedicine
(This special issue belongs to the Section Bioinformatics and Systems Biology)
The Future of Protein Research: New Paradigms and Transformative Technologies
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 362 | Submission Open
Keywords: protein science; proteomics; cryo-electron microscopy; AI-driven approaches; interactomes; drug discovery; synthetic biology; protein structure and function; protein engineering; biophysics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Cellular Regulation of Inflammatory Diseases
edited by
submission deadline 31 Dec 2026 | Viewed by 341 | Submission Open
Keywords: inflammatory diseases; inflammation; neutrophils; monocytes/macrophages; T cells; B cells; NK cells; dendritic cells
(This special issue belongs to the Section Cellular Biochemistry)
Mechanisms of Chronic Diseases and Intervention Strategies: The Role of Bioactive Compounds in Foods and Herbal Extracts
edited by and Xiang Li
submission deadline 31 Dec 2026 | Viewed by 330 | Submission Open
Keywords: chronic diseases; multi-target intervention; bioactive compounds; medicine-food homology; herbal extracts; omics technologies; multi-target modulation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Diagnostics and Targeted Therapies for Breast and Prostate Cancers
edited by , Ekaterina Bezverkhniaia and Panagiotis Kanellopoulos
submission deadline 31 Dec 2026 | Viewed by 317 | Submission Open
Keywords: molecular imaging; targeted therapy; prostate cancer; breast cancer; theranostics
(This special issue belongs to the Section Biological Factors)
Enolase: Molecular Functions and Pathological Roles in Health and Disease
edited by
submission deadline 31 Dec 2026 | Viewed by 316 | Submission Open
Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Cardiometabolic Health, 2nd Edition
edited by Pamela Senesi and
submission deadline 31 Dec 2026 | Viewed by 295 | Submission Open
Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine
(This special issue belongs to the Section Cellular Biochemistry)
Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives
edited by
submission deadline 31 Dec 2026 | Viewed by 276 | Submission Open
Keywords: ABC transporters; drug disposition; drug resistance; pharmacokinetics; pharmacodynamics; pharmacogenetics; single nucleotide polymorphisms (SNPs)
(This special issue belongs to the Section Chemical Biology)
Molecular Genomics for Plant Stress Resilience and Improvement
edited by and Moxian Chen
submission deadline 31 Dec 2026 | Viewed by 273 | Submission Open
Keywords: plant stress resilience; molecular genomics; abiotic stress; transcriptomics; proteomics; epigenetics; gene regulation; crop improvement; climate-smart agriculture
(This special issue belongs to the Section Molecular Genetics)
Forces Driving Macromolecular Recognition: Role in Drug Design and Discovery
edited by David P. Remeta and
submission deadline 31 Dec 2026 | Viewed by 242 | Submission Open
Keywords: macromolecular recognition; drug design and discovery; biomolecular structure and dynamics; computational modeling; ligand–receptor binding energetics; drug-target interactions; thermodynamic forces; protein-ligand binding; drug discovery and optimization; protein-nucleic acid interactions; intrinsically disordered proteins; protein aggregation and disease
(This special issue belongs to the Section Chemical Biology)
Molecular and Cellular Mechanisms of Biomaterial–Tissue Interactions
edited by , Xin Xiong, Korzinskas Tadas and
submission deadline 31 Dec 2026 | Viewed by 242 | Submission Open
Keywords: biomaterials; cell–material interface; mechanotransduction; integrin signaling; protein corona; immune response; macrophage polarization; foreign body reaction; degradation; bioactive coatings; tissue regeneration; fibrosis; angiogenesis; multi-omics; quantitative histology
(This special issue belongs to the Section Bio-Engineered Materials)
Molecular Genetics and Molecular Diagnosis in Precision Oncology
edited by Andrea Ferreira-Gonzalez
submission deadline 31 Dec 2026 | Viewed by 226 | Submission Open
Keywords: cancer; genetics; molecular therapy; immunotherapy; molecular genetics; molecular diagnostics; NGS; liquid biopsy
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Cell Reprogramming and Differentiation
edited by
submission deadline 31 Dec 2026 | Viewed by 220 | Submission Open
Keywords: stem cell differentiating stage factors; cell reprogramming; cell differentiation; stem cells; epigenetic regulation; cellular plasticity
(This special issue belongs to the Section Cellular Biochemistry)
Bone Tissue Morphology: From Pathophysiological Mechanisms to Regenerative Strategies
edited by
submission deadline 31 Dec 2026 | Viewed by 205 | Submission Open
Keywords: osteoporosis; bone cancer; fracture repair; regenerative biomaterials; bone remodeling; molecular mechanisms; biomechanical mechanisms; bone imaging techniques
(This special issue belongs to the Section Molecular Medicine)
Harnessing DNA Amplification for Biosensing: From Molecular Mechanisms to Diagnostic Platforms
edited by Mariarosaria De Falco and
submission deadline 31 Dec 2026 | Viewed by 204 | Submission Open
Keywords: infectious diseases; isothermal DNA/RNA amplification; molecular biology–based diagnostic technologies; point-of-care (POC) diagnostics; rapid pathogen detection
(This special issue belongs to the Section Molecular Biology)
Bridging Molecular Biology and Machine Learning to Understand Brain Network Function and Plasticity
edited by
submission deadline 31 Dec 2026 | Viewed by 201 | Submission Open
Keywords: brain network plasticity; molecular neuroscience; machine learning in neuroscience; multimodal data integration; translational neuroscience
(This special issue belongs to the Section Bioinformatics and Systems Biology)
The Role of Non-Coding RNAs in Female and Male Reproduction: Molecular Mechanisms and Clinical Implications
edited by , Rosalia Battaglia and
submission deadline 31 Dec 2026 | Viewed by 197 | Submission Open
Keywords: female and male fertility; non-coding RNA; epigenetic fertility regulation; epigenetic biomarkers; reproductive dysfunctions
(This special issue belongs to the Section Molecular Genetics)
Molecular Genetics of Psychiatric Disorders submission deadline 31 Dec 2026 | Viewed by 182 | Submission Open
Keywords: molecular psychiatry; functional genomics; candidate gene studies; genome-wide association studies (GWAS); epigenetics
(This special issue belongs to the Section Molecular Genetics)
New Insights into the Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition
edited by and Flavio Faletra
submission deadline 31 Dec 2026 | Viewed by 181 | Submission Open
Keywords: neurodevelopmental disorders; NGS analysis and reanalysis; pathomechanisms; phenotypic spectra; phenotype–genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Circadian Signaling in Regulation of Immune Response: New Insights into the Interaction of the Clock with Inflammatory Signaling
edited by and Tobias Eckle
submission deadline 31 Dec 2026 | Viewed by 174 | Submission Open
Keywords: circadian rhythms; BMAL1, CLOCK, PER, and CRY; zeitgebers; suprachiasmatic nucleus; inflammation signaling; NLRP3 inflammasome; reactive oxygen species; immune responses; sleep apnea; chronotherapy; dark light cycle; circadian synchronization; chronobiology
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Mechanisms of Nano-Rare Diseases, Interventions and Lessons Learned from ASO Treatments
edited by Stanley T. Crooke
submission deadline 31 Dec 2026 | Viewed by 159 | Submission Open
Keywords: nano-rare mutations; antisense oligonucleotides (ASOs); individualized medicine; FDA guidance; patient community
(This special issue belongs to the Section Molecular Medicine)
Biomolecular Basis in Mycobacterium Tuberculosis (Mtb) Infection: Disease Development and Control
edited by
submission deadline 31 Dec 2026 | Viewed by 156 | Submission Open
Keywords: Mycobacterium tuberculosis; biomolecules; host immunity; vaccine development; drug resistance; biomarkers; vaccine; diagnosis; therapeutic
(This special issue belongs to the Section Molecular Medicine)
Advanced Biomaterials for Targeted Drug Delivery and Microbiome Modulation
edited by
submission deadline 31 Dec 2026 | Viewed by 153 | Submission Open
Keywords: biomaterials; immunomodulation; microbiome; drug delivery; precision medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Kinases Signaling in Cancer 2026
edited by
submission deadline 31 Dec 2026 | Viewed by 139 | Submission Open
Keywords: kinases signaling; cancer; signaling pathways
(This special issue belongs to the Section Cellular Biochemistry)
Research Progress in Pediatric Oncology
edited by Emmanouel Hatzipantelis and
submission deadline 31 Dec 2026 | Viewed by 114 | Submission Open
Keywords: pediatric oncology; childhood cancer; targeted therapy; immunotherapy; precision medicine; supportive care; infection; survivorship; global health
(This special issue belongs to the Section Molecular Medicine)
Amyloid-Beta and Alzheimer’s Disease, 2nd Edition
edited by
submission deadline 31 Dec 2026 | Viewed by 102 | Submission Open
Keywords: Alzheimer's disease (AD) ; amyloid-beta (Aβ) ; neurotoxicity of Aβ ; Aβ phagocytosis ; Aβ clearance ; neuroinflammation in AD ; glial cells in AD ; tau protein ; anti-Aβ monoclonal antibodies; CAR-A therapy
(This special issue belongs to the Section Cellular Biochemistry)
Glycosylation in Cellular Signaling and Diseases
edited by Xiaodong Gao and
submission deadline 31 Dec 2026 | Viewed by 92 | Submission Open
Keywords: biosynthetic pathways of glycans; glycosignaling; glycan functions; glycomics and glycoproteomics; glycobiomarkers
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Decoding Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation
edited by Guanglin Zhang and
submission deadline 31 Dec 2026 | Viewed by 69 | Submission Open
Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut–brain axis; cognitive rehabilitation
(This special issue belongs to the Section Molecular Biology)
Spinal Muscular Atrophy: From Genetics to Therapeutics
edited by Eduardo F. Tizzano and
submission deadline 31 Dec 2026 | Viewed by 45 | Submission Open
Keywords: spinal muscular atrophy; motor neuron; survival motor neuron genes; genetic modifiers; disease-modifying therapies; multisystemic disease; synapsis; later-onset phenotypes
(This special issue belongs to the Section Molecular Medicine)
Signaling Networks and Novel Biomarkers for Precision Cancer Medicine
edited by
submission deadline 8 Jan 2027 | 1 articles | Viewed by 519 | Submission Open
Keywords: biomarkers; cancer signaling networks; ctDNA; ctRNA; extracellular vesicles; liquid biopsy; multi-omics; precision oncology; proteomics; TME; therapy resistance
(This special issue belongs to the Section Molecular Medicine)
Inflammasome and Inflammasome Inhibitors
edited by
submission deadline 8 Jan 2027 | Viewed by 182 | Submission Open
Keywords: inflammasomes; pyroptosis; innate immunity; inflammasome modulators; inhibitors; inflammatory diseases; drug discovery; translational research
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration
edited by and
submission deadline 10 Jan 2027 | 3 articles | Viewed by 3587 | Submission Open
Keywords: MSC; vesicles; exosomes; tissue repair and regeneration
Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke
edited by
submission deadline 15 Jan 2027 | 1 articles | Viewed by 1797 | Submission Open
Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases
(This special issue belongs to the Section Molecular Medicine)
Discovery of Therapeutic Target Genes in Oral and Craniofacial Cancers: From Molecular Signatures to Precision Dentistry
edited by
submission deadline 15 Jan 2027 | Viewed by 215 | Submission Open
Keywords: oral squamous cell carcinoma; head and neck cancer; therapeutic targets; target genes; biomarkers; saliva diagnostics; oral potentially malignant disorders; epigenetics; transcriptomics; single-cell; microbiome; precision dentistry
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of the Epidermal Microenvironment in Pigmentation Disorders
edited by
submission deadline 15 Jan 2027 | Viewed by 176 | Submission Open
Keywords: epidermal microenvironment; melanocyte homeostasis; intercellular signaling networks; epidermal cell–cell crosstalk; pigmentation disorders
(This special issue belongs to the Section Molecular Medicine)
Albumin in Health and Disease: Physiological Roles, Pathogenic Mechanisms, and Biomedical Applications
edited by
submission deadline 15 Jan 2027 | Viewed by 147 | Submission Open
Keywords: albumin; antioxidant; biomarker; drug delivery system; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs
edited by
submission deadline 18 Jan 2027 | 2 articles | Viewed by 3594 | Submission Open
Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs
Amino Acids and Their Metabolism in Disease
edited by
submission deadline 20 Jan 2027 | 2 articles | Viewed by 2574 | Submission Open
Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Role of Oxidative Stress in Vascular Diseases submission deadline 20 Jan 2027 | 1 articles | Viewed by 1018 | Submission Open
Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk
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