Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Industrial Microoganisms and Enzyme Technologies
edited by
submission deadline 30 Nov 2025 | Submission Open
Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism
(This special issue belongs to the Section Enzymology)
Lipid Signaling in Human Disease
edited by Berit Johansen and Felicity Ashcroft
submission deadline 10 Dec 2025 | Viewed by 33 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Role of TRAF in Regulating Inflammation and Cell Survival
edited by Ali Abdul-Sater
submission deadline 15 Dec 2025 | 2 articles | Viewed by 3845 | Submission Open
Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival
(This special issue belongs to the Section Biological Factors)
Novel Insights on Cancer Stem Cells
edited by
submission deadline 15 Dec 2025 | Viewed by 433 | Submission Open
Keywords: cancer stem cells; cancer initiating cells; stemness; self-renewal; therapy resistance; epigenetic reprogramming
(This special issue belongs to the Section Molecular Medicine)
Nanomaterials and Smart Delivery Systems in Combating Drug-Resistant Infections
edited by Hanif Haidari and
submission deadline 15 Dec 2025 | Viewed by 135 | Submission Open
Keywords: nanomaterials; antimicrobial biomolecules; tissue engineering; metallic nanoparticles; smart hydrogels; drug-resistant infections; controlled drug delivery; biomaterial-tissue interactions
(This special issue belongs to the Section Bio-Engineered Materials)
Recent Molecular Research on Protein Structure and Function
edited by
submission deadline 15 Dec 2025 | Viewed by 92 | Submission Open
Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology
(This special issue belongs to the Section Molecular Biology)
Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander
edited by Sonia Distante and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 28004 | Submission Open
Keywords: medical biochemistry; endocrinology; neurotoxic metals
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in the Natural and Bio-Derived Molecules Section submission deadline 31 Dec 2025 | 7 articles | Viewed by 20889 | Submission Open
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Cell Biology and Biomedical Application of Galectins submission deadline 31 Dec 2025 | 4 articles | Viewed by 10834 | Submission Open
Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms in DNA and RNA Damage and Repair submission deadline 31 Dec 2025 | 6 articles | Viewed by 9512 | Submission Open
Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress
(This special issue belongs to the Section Molecular Biomarkers)
New Insight into the Molecular Genetics of Neurodevelopmental Disorders
edited by and Flavio Faletra
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8823 | Submission Open
Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Advances in Melanoma Targeted Therapy
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7164 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches
edited by and Maria Nikolaou
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6079 | Submission Open
Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 31 Dec 2025 | 3 articles | Viewed by 5718 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Antitumor Agents from Natural Sources 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 5578 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Natural Bioactives as Leading Molecules for Drug Development
edited by , and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4997 | Submission Open
Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Insights from the Editorial Board Members
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 4459 | Submission Open
Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials
Advances in Galectins
edited by Anu Paul and Diyoly Ayona
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4301 | Submission Open
Keywords: galectins; carbohydrate-binding proteins; galectin– microbe
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Role of Non-Coding RNAs in Health and Disease submission deadline 31 Dec 2025 | 5 articles | Viewed by 4129 | Submission Open
Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 31 Dec 2025 | 2 articles | Viewed by 2942 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 31 Dec 2025 | 2 articles | Viewed by 2911 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2837 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1962 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1924 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Melatonin in Normal Physiology and Disease, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 1621 | Submission Open
Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis
(This special issue belongs to the Section Molecular Biology)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1569 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 31 Dec 2025 | 1 articles | Viewed by 1551 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
New Insights into Molecular Mechanisms and Therapeutics for Malaria
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1549 | Submission Open
Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology
(This special issue belongs to the Section Molecular Medicine)
Molecular Biomarkers in Cardiology 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1436 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
Tumour Suppressor Genes: The Guardians of Cell Integrity
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1220 | Submission Open
Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1161 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
(This special issue belongs to the Section Chemical Biology)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and Rachael Dickman
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1124 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Necrotic Cell Death Mechanisms and Therapies
edited by and
submission deadline 31 Dec 2025 | Viewed by 622 | Submission Open
Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Signaling Pathways as Therapeutic Targets for Cancer
edited by Fabian Benencia
submission deadline 31 Dec 2025 | 1 articles | Viewed by 543 | Submission Open
Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies
(This special issue belongs to the Section Molecular Biology)
Molecular Basis of Pathogenesis in Autoimmune Diseases
edited by I-Tsu Chyuan and
submission deadline 31 Dec 2025 | Viewed by 510 | Submission Open
Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets
(This special issue belongs to the Section Molecular Medicine)
Phytohormones 2024–2025
edited by Guzel Kudoyarova
submission deadline 31 Dec 2025 | Viewed by 469 | Submission Open
Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 464 | Submission Open
Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning
(This special issue belongs to the Section Chemical Biology)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 31 Dec 2025 | Viewed by 311 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches submission deadline 31 Dec 2025 | Viewed by 267 | Submission Open
Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 31 Dec 2025 | Viewed by 251 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Functional Peptides and Their Interactions (3rd Edition) submission deadline 31 Dec 2025 | Viewed by 189 | Submission Open
Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications
edited by and Eleonora Martegani
submission deadline 31 Dec 2025 | Viewed by 134 | Submission Open
Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits
Sjogren’s Syndrome: Recent Updates and Perspectives
edited by
submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open
Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines
State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia
edited by and
submission deadline 31 Dec 2025 | Viewed by 110 | Submission Open
Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning
Molecular Mechanisms Underlying Liver Diseases: 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 85 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism submission deadline 31 Dec 2025 | Viewed by 73 | Submission Open
Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation
(This special issue belongs to the Section Molecular Biology)
Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies
edited by Takashi Onodera and
submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open
Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)
p53 Family: The Molecular Landscape in Cancer and Beyond
edited by and Michele Pellegrino
submission deadline 31 Dec 2025 | Viewed by 59 | Submission Open
Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy
(This special issue belongs to the Section Molecular Biology)
Ion Channels in Neurological and Psychological Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 56 | Submission Open
Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target
(This special issue belongs to the Section Molecular Biology)
Lung Cancer: From Molecular Basis to Therapy
edited by
submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open
Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic
(This special issue belongs to the Section Molecular Biology)
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