Glycosylation in Cellular Signaling and Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 165

Editors


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Guest Editor
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
Interests: N-glycans; Alg glycosyltransferases; ALG-CDG; chemo-enzymatic synthesis; rare sugar

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Guest Editor
1. Division of Regulatory Glycobiology, Graduate School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
2. Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan
Interests: N-glycans; core fucosylation; O-GlcNAc; hyaluronan; glycosyltransferases; cancer biology; cell adhesion; neuroinflammation; mental disorders; glycan-related diseases

Special Issue Information

Dear Colleagues,

Glycosylation is a common post-translational modification in mammalian cells. Abnormal glycosylation is a hallmark of many diseases, including inflammatory disorders, infectious diseases, cancer, and neurodegenerative or neuropsychiatric disorders. Glycoconjugates, including glycoproteins, glycolipids, and glycosaminoglycans, play pivotal roles in cellular recognition, signaling, and immune responses across physiological and pathological conditions. Understanding the biosynthesis, structural diversity, and metabolism of glycans will help elucidate the molecular basis of disease mechanisms, support biomarker discovery, and inform therapeutic targeting, thereby paving the way for novel diagnostic and therapeutic strategies and precision medicine. This special issue on Glycosylation in Cellular Signaling and Diseases provides a platform for reporting the latest original findings or reviews in glycobiology, including the following keywords. Glycosylation in disease; Biosynthetic pathways of glycans; Glycosignaling; Glycan functions; Glycomics and glycoproteomics; Glycobiomarkers.

Prof. Dr. Xiaodong Gao
Prof. Dr. Jianguo Gu
Guest Editors

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Keywords

  • biosynthetic pathways of glycans
  • glycosignaling
  • glycan functions
  • glycomics and glycoproteomics
  • glycobiomarkers

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Published Papers (1 paper)

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Review

42 pages, 7516 KB  
Review
Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis
by Zhishan Xu, Dingbo Song, Fangqi Hu, Qiuhan Liang, Mengyao Zhang, Chao Lei, Jinyuan Li, Haiyi Guo, Zhongbin Deng and Zishan Yang
Biomolecules 2026, 16(9), 1226; https://doi.org/10.3390/biom16091226 - 24 Aug 2026
Abstract
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal disorders that pose significant threats to human health and share common pathological features, including intestinal mucosal barrier disruption and gut microbiota dysbiosis, in which fucosylation acts as a critical regulatory mediator. Fucosylation [...] Read more.
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal disorders that pose significant threats to human health and share common pathological features, including intestinal mucosal barrier disruption and gut microbiota dysbiosis, in which fucosylation acts as a critical regulatory mediator. Fucosylation is a highly conserved post-translational glycosylation modification involving the enzymatic transfer of fucose residues to glycoproteins and glycolipids. This tightly regulated process plays essential roles in maintaining intestinal homeostasis, mediating host–microbiota interactions and regulating immune responses. This review adopts a physiology-to-pathology framework, delineating fucosylation’s operational principles in healthy intestines and its dysregulation in IBD and CRC. It summarizes the spatial distribution of fucosylation, its regulatory mechanisms, and its roles in disease pathogenesis, and also discusses its potential as a diagnostic biomarker and therapeutic target. Finally, this review highlights future research directions to bridge mechanistic insights with clinical translation, emphasizing the promise of fucosylation in the precision diagnosis and treatment of intestinal disorders. Full article
(This article belongs to the Special Issue Glycosylation in Cellular Signaling and Diseases)
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