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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Signal Transduction and Pathway Regulation in Cancer

edited by

Carmen Cristina Diaconu

submission deadline 30 Apr 2026 | 2 articles | Viewed by 561 | Submission Open

Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Molecular Biology)

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Apr 2026 | Viewed by 406 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches

edited by

Milica Perišić Nanut

submission deadline 30 Apr 2026 | Viewed by 381 | Submission Open

Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors

(This special issue belongs to the Section Molecular Biology)

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Apr 2026 | Viewed by 352 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Apr 2026 | Viewed by 278 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Apr 2026 | Viewed by 231 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications

edited by George Kokotos and

Christiana Mantzourani

submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open

Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes

(This special issue belongs to the Section Molecular Medicine)

Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

edited by

Virginia Tancredi

Roberto Bonanni

and

Ida Cariati

submission deadline 30 Apr 2026 | Viewed by 166 | Submission Open

Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise

(This special issue belongs to the Section Biological Factors)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Apr 2026 | Viewed by 163 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms and Current Treatment Strategy of Sarcomas

edited by

Katia Scotlandi

and

Caterina Mancarella

submission deadline 30 Apr 2026 | Viewed by 155 | Submission Open

Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target

(This special issue belongs to the Section Molecular Medicine)

Glycomics in Health, Aging and Disease

edited by

Domenico Garozzo

submission deadline 30 Apr 2026 | Viewed by 154 | Submission Open

Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Structure-Based Inhibitor/Drug Design

edited by

Guoping Zhou

submission deadline 30 Apr 2026 | Viewed by 154 | Submission Open

Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)

The Immune Response to Severe Trauma

edited by

Jon Hazeldine

and David N Naumann

submission deadline 30 Apr 2026 | Viewed by 150 | Submission Open

Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care

(This special issue belongs to the Section Molecular Medicine)

Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function

edited by

Keiko Kawauchi

and Tamaki Endoh

submission deadline 30 Apr 2026 | Viewed by 144 | Submission Open

Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders

edited by Katerina Karaivazoglou and

Konstantinos Kotsis

submission deadline 30 Apr 2026 | Viewed by 138 | Submission Open

Keywords: microbiome– gut– brain axis; neurodevelopmental disorders; autism; schizophrenia; intestinal dysbiosis

(This special issue belongs to the Section Molecular Biology)

Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition

edited by

Carlo Perricone

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms, Pathogenesis, and Treatment of Cardiovascular Diseases

edited by

Mahavir Singh

and

Zsuzsa Bagoly

submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open

Keywords: cardiovascular diseases; molecular pathogenesis; genomics and metabolomics; AI/ML diagnostics; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

AI-Driven Approaches to Neurodegeneration: From Disease Models to Therapeutic Strategies

edited by

Thomas R. Caulfield

, Jianfu Li and Naeyma N. Islam

submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open

Keywords: artificial intelligence (AI); neurodegeneration; disease modeling; therapeutic discovery; machine learning in biomedicine

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies

edited by

Ximena Maria Muresan

and

Ioana Ecaterina Pralea

submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open

Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy

(This special issue belongs to the Section Molecular Biomarkers)

Therapeutic Applications of Extracellular Vesicles in Inflammation and Immunoregulation

edited by

Ahmed Abdal Dayem

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: extracellular vesicles; inflammatory diseases; immunomodulation; regenerative therapy; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Application of Spectral Analysis in Disease Diagnosis and Treatment

edited by

Entesar Al-Hetlani

and

Igor Lednev

submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open

Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning

(This special issue belongs to the Section Molecular Medicine)

Pathophysiological Insights into Congenital Myasthenic Syndromes

edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model

(This special issue belongs to the Section Molecular Medicine)

The Role of Scavenger Receptors in Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: scavenger receptor; CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Biological Factors)

Structural and Functional Insights into Metalloantibiotics

edited by

Li-June Ming

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance

(This special issue belongs to the Section Enzymology)

Molecular Circuits of Cell Fate Reprogramming and Plasticity

edited by

Myon Hee Lee

submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open

Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional; post-transcriptional; and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models

(This special issue belongs to the Section Cellular Biochemistry)

Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment

edited by Eleni E. Mylona and

Dimitris Kounatidis

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies

Molecular Genetics and Molecular Diagnosis in Precision Oncology

edited by Andrea Ferreira-Gonzalez

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: cancer; genetics; molecular therapy; immunotherapy; molecular genetics; molecular diagnostics; NGS; liquid biopsy

(This special issue belongs to the Section Molecular Genetics)

Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease

edited by

Carlos Rosado

submission deadline 1 May 2026 | Viewed by 160 | Submission Open

Keywords: diabetic kidney disease; pathogenesis; novel biomarkers; metabolic memory; SGLT2 inhibitors; fibrotic pathways; epigenetic modification; multi-target pharmacotherapy

Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting

edited by Amiya Kumar Patra

submission deadline 3 May 2026 | 2 articles | Viewed by 2274 | Submission Open

Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders

(This special issue belongs to the Section Molecular Biology)

Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Harrys Kishore Charles Jacob

and

John Lalith Charles Richard

submission deadline 10 May 2026 | Viewed by 116 | Submission Open

Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 15 May 2026 | 7 articles | Viewed by 18697 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Protein Self-Assembly in Diseases and Function

edited by

Anoop Arunagiri

, Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez

submission deadline 15 May 2026 | 2 articles | Viewed by 2081 | Submission Open

Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cancer Biology: Machine Learning and Bioinformatics

edited by Annalisa Santucci,

Ottavia Spiga

and

Anna Visibelli

submission deadline 15 May 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: cancer biology; bioinformatics; machine learning; big data

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets

edited by

Emily Golden

and

Priya Gopal Krishnan

submission deadline 15 May 2026 | Viewed by 139 | Submission Open

Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing

Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 15 May 2026 | Viewed by 128 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies

edited by

Xin Xu

and

Lawrence Rasmussen

submission deadline 16 May 2026 | Viewed by 134 | Submission Open

Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor

(This special issue belongs to the Section Biological Factors)

Industrial Microorganisms and Enzyme Technologies

edited by

Yunjun Yan

submission deadline 20 May 2026 | 4 articles | Viewed by 4222 | Submission Open

Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism

(This special issue belongs to the Section Enzymology)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 May 2026 | 2 articles | Viewed by 2862 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Notch and Its Regulation in Health and Disease

edited by

Martin Baron

submission deadline 20 May 2026 | 1 articles | Viewed by 1212 | Submission Open

Keywords: Notch; signalling; development; diseases

(This special issue belongs to the Section Molecular Medicine)

Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators

edited by

Iogann Tolbatov

submission deadline 23 May 2026 | Viewed by 134 | Submission Open

Keywords: protein– protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications

edited by Li Fan

submission deadline 23 May 2026 | Viewed by 133 | Submission Open

Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Key Mechanisms in the Pathogenesis of ALS

edited by

Natalia N. Ninkina

and

Michail S. Kukharsky

submission deadline 30 May 2026 | Viewed by 58 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron disease; neurodegeneration; pathogenesis; protein aggregation; non-coding RNA; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 May 2026 | 10 articles | Viewed by 30713 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 May 2026 | 5 articles | Viewed by 19016 | Submission Open

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research

edited by

Riccardo Fesce

submission deadline 31 May 2026 | 2 articles | Viewed by 15340 | Submission Open

Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 May 2026 | 4 articles | Viewed by 14607 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities

edited by

Antonio Garrido

submission deadline 31 May 2026 | 2 articles | Viewed by 8646 | Submission Open

Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition

(This special issue belongs to the Section Biological Factors)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 31 May 2026 | 1 articles | Viewed by 7178 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 May 2026 | 2 articles | Viewed by 6481 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 31 May 2026 | 4 articles | Viewed by 6232 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

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