Psilocybe Mushrooms Constituents—Therapeutic Implications

A Special Issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 3618

Editors


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Guest Editor
National Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Lismore, NSW, Australia
Interests: scheduled substances for clinical use; Parkinson’s disease; personalized medicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Lismore, NSW, Australia
Interests: scheduled substances for clinical use; cancer; clinical trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Psilocybin research has significantly developed in the last decade, but has remained in the space of specific mental health conditions. Furthermore, its biological origins have largely been ignored, as it is only a part of the secondary metabolite arsenal produced by the Psilocybe genus.

We invite submissions on the global Psilocybe community with a specific focus on the intersection of Psilocybe constituents and health outcomes. We will consider pre-clinical (in vitro and in vivo) and clinical primary research papers, in addition to well-structured reviews on Psilocybe use in the context of any health condition. While we will consider papers specifically focusing on psilocybin, we also invite papers that describe interactions of other Psilocybe constituents with a health phenotype/outcome.

You may choose our Joint Special Issue in Cells.

Dr. Andrea Bugarcic
Dr. Janet Schloss
Guest Editors

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Keywords

  • Psilocybe mushrooms
  • psilocybin
  • pre-clinical research
  • neurodegeneration

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Published Papers (1 paper)

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Review

47 pages, 5977 KB  
Review
Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit–Risk Considerations in Policy and Clinical Development
by Stefanie Enriquez-Geppert, Lisa Bevers, Arvid Rosander, Peter Fodran and Vince Polito
Biomolecules 2026, 16(7), 983; https://doi.org/10.3390/biom16070983 - 3 Jul 2026
Viewed by 2628
Abstract
Naturally derived psilocybin is widely used, yet its therapeutic potential, pharmacological distinctiveness and regulatory feasibility remain understudied. This review evaluates the potential of naturally derived psilocybin using a six-criterion framework to evaluate: (1) therapeutic benefit, (2) safety and tolerability, (3) pharmacological uniqueness vs. [...] Read more.
Naturally derived psilocybin is widely used, yet its therapeutic potential, pharmacological distinctiveness and regulatory feasibility remain understudied. This review evaluates the potential of naturally derived psilocybin using a six-criterion framework to evaluate: (1) therapeutic benefit, (2) safety and tolerability, (3) pharmacological uniqueness vs. synthetic psilocybin, (4) identity and composition control, (5) dose precision and stability, and (6) ecological sustainability. This paper answers three key questions about naturally derived psilocybin: Does it show therapeutic potential? Does it differ from synthetic psilocybin? Can it meet medicinal standards? Findings suggest perceived therapeutic benefits from naturally derived psilocybin across mental health domains, though evidence of causal efficacy is mixed. Safety profiles are favorable but context-dependent, with risks in vulnerable populations. Some preliminary preclinical evidence indicates possible entourage effects, but human validation is lacking. Dose precision varies, with purified psilocybin being most reliable, followed by standardized extracts, alcoholic, aqueous, and whole biomass preparations. Scalable cultivation is feasible but faces sustainability challenges. Key gaps include a lack of controlled trials, longitudinal safety evaluations, and standardization. We provide a phased research roadmap, which proposes short-term studies to establish safety, mid-term mechanistic and standardization efforts, and long-term integration into therapeutic, cultural, and ecological systems. This review highlights the promise of naturally derived psilocybin but underscores the need for rigorous evidence to support regulatory acceptance and clinical use. Full article
(This article belongs to the Special Issue Psilocybe Mushrooms Constituents—Therapeutic Implications)
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