Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomolecular Sciences and Precision Medicine in Vascular Disease
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 661 | Submission Open
Keywords: precision medicine; vascular disease; vascular surgery
(This special issue belongs to the Section Molecular Medicine)
Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies
edited by
submission deadline 30 Apr 2026 | Viewed by 374 | Submission Open
Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies
(This special issue belongs to the Section Molecular Medicine)
Omics in Entomology: Unraveling the Molecular Mechanisms of Insects submission deadline 30 Apr 2026 | Viewed by 305 | Submission Open
Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics
(This special issue belongs to the Section Molecular Genetics)
Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators
edited by
submission deadline 30 Apr 2026 | Viewed by 260 | Submission Open
Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity
(This special issue belongs to the Section Chemical Biology)
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Apr 2026 | Viewed by 244 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
Cell Death and Clearance
edited by and Jascinta Santavanond
submission deadline 30 Apr 2026 | Viewed by 210 | Submission Open
Keywords: cell death; apoptosis; efferocytosis; cell clearance
(This special issue belongs to the Section Molecular Medicine)
Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications
edited by George Kokotos and
submission deadline 30 Apr 2026 | Viewed by 190 | Submission Open
Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Structure-Based Inhibitor/Drug Design
edited by
submission deadline 30 Apr 2026 | Viewed by 137 | Submission Open
Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)
Functional Structures in RNA Viruses
edited by Riccardo Delli Ponti, , and Laura Broglia
submission deadline 30 Apr 2026 | Viewed by 136 | Submission Open
Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Molecular Mechanisms and Current Treatment Strategy of Sarcomas submission deadline 30 Apr 2026 | Viewed by 122 | Submission Open
Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target
(This special issue belongs to the Section Molecular Medicine)
Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function
edited by and Tamaki Endoh
submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Immune Response to Severe Trauma
edited by and David N Naumann
submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care
(This special issue belongs to the Section Molecular Medicine)
Glycomics in Health, Aging and Disease
edited by
submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open
Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open
Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise
(This special issue belongs to the Section Biological Factors)
Application of Spectral Analysis in Disease Diagnosis and Treatment submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open
Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning
(This special issue belongs to the Section Molecular Medicine)
Pathophysiological Insights into Congenital Myasthenic Syndromes
edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen
submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open
Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms, Pathogenesis, and Treatment of Cardiovascular Diseases submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: cardiovascular diseases; molecular pathogenesis; genomics and metabolomics; AI/ML diagnostics; precision medicine; translational research
(This special issue belongs to the Section Molecular Medicine)
Signal Transduction and Pathway Regulation in Cancer submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis
(This special issue belongs to the Section Molecular Biology)
Therapeutic Applications of Extracellular Vesicles in Inflammation and Immunoregulation
edited by
submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open
Keywords: extracellular vesicles; inflammatory diseases; immunomodulation; regenerative therapy; therapeutic applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders
edited by Katerina Karaivazoglou and
submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open
Keywords: microbiome– gut– brain axis; neurodevelopmental disorders; autism; schizophrenia; intestinal dysbiosis
(This special issue belongs to the Section Molecular Biology)
Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition
edited by
submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open
Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity
(This special issue belongs to the Section Molecular Medicine)
Gas Chromatography–Mass Spectrometry as a Versatile Tool for Plant Metabolomics submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open
Keywords: GC-MS; plant metabolomics; biologically active metabolites; metabolomics-assisted breeding; stress response; multi-omics integration
(This special issue belongs to the Section Molecular Biology)
The Role of Scavenger Receptors in Health and Disease
edited by and Mihail E. Hinescu
submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open
Keywords: scavenger receptor; CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker
(This special issue belongs to the Section Biological Factors)
Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open
Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy
(This special issue belongs to the Section Molecular Biomarkers)
AI-Driven Approaches to Neurodegeneration: From Disease Models to Therapeutic Strategies
edited by , Jianfu Li and Naeyma N. Islam
submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open
Keywords: artificial intelligence (AI); neurodegeneration; disease modeling; therapeutic discovery; machine learning in biomedicine
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Structural and Functional Insights into Metalloantibiotics
edited by
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance
(This special issue belongs to the Section Enzymology)
Molecular Genetics and Molecular Diagnosis in Precision Oncology
edited by Andrea Ferreira-Gonzalez
submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open
Keywords: cancer; genetics; molecular therapy; immunotherapy; molecular genetics; molecular diagnostics; NGS; liquid biopsy
(This special issue belongs to the Section Molecular Genetics)
Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment
edited by Eleni E. Mylona and
submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open
Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies
Molecular Circuits of Cell Fate Reprogramming and Plasticity
edited by
submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open
Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional; post-transcriptional; and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models
(This special issue belongs to the Section Cellular Biochemistry)
Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease
edited by
submission deadline 1 May 2026 | Viewed by 139 | Submission Open
Keywords: diabetic kidney disease; pathogenesis; novel biomarkers; metabolic memory; SGLT2 inhibitors; fibrotic pathways; epigenetic modification; multi-target pharmacotherapy
Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting
edited by Amiya Kumar Patra
submission deadline 3 May 2026 | 2 articles | Viewed by 1888 | Submission Open
Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders
(This special issue belongs to the Section Molecular Biology)
Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies submission deadline 10 May 2026 | Viewed by 92 | Submission Open
Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 15 May 2026 | 7 articles | Viewed by 17507 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Protein Self-Assembly in Diseases and Function
edited by , Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez
submission deadline 15 May 2026 | 1 articles | Viewed by 1745 | Submission Open
Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Cancer Biology: Machine Learning and Bioinformatics
edited by Annalisa Santucci, and
submission deadline 15 May 2026 | 1 articles | Viewed by 668 | Submission Open
Keywords: cancer biology; bioinformatics; machine learning; big data
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems submission deadline 15 May 2026 | Viewed by 114 | Submission Open
Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets submission deadline 15 May 2026 | Viewed by 105 | Submission Open
Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing
Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies
edited by and
submission deadline 16 May 2026 | Viewed by 112 | Submission Open
Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor
(This special issue belongs to the Section Biological Factors)
Industrial Microorganisms and Enzyme Technologies
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 3523 | Submission Open
Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism
(This special issue belongs to the Section Enzymology)
Advances in the Structure and Function of Microtubule-Associated Motor Proteins
edited by Arne Gennerich
submission deadline 20 May 2026 | 1 articles | Viewed by 2019 | Submission Open
Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Notch and Its Regulation in Health and Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1046 | Submission Open
Keywords: Notch; signalling; development; diseases
(This special issue belongs to the Section Molecular Medicine)
Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications
edited by Li Fan
submission deadline 23 May 2026 | Viewed by 122 | Submission Open
Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators
edited by
submission deadline 23 May 2026 | Viewed by 106 | Submission Open
Keywords: protein– protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Key Mechanisms in the Pathogenesis of ALS
edited by and Michail S. Kukharsky
submission deadline 30 May 2026 | Submission Open
Keywords: amyotrophic lateral sclerosis; motor neuron disease; neurodegeneration; pathogenesis; protein aggregation; non-coding RNA; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Tissue Calcification in Normal and Pathological Environments
edited by
submission deadline 31 May 2026 | 9 articles | Viewed by 28125 | Submission Open
Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death
(This special issue belongs to the Section Molecular Medicine)
Liver Damage and Associated Metabolic Disorders
edited by
submission deadline 31 May 2026 | 5 articles | Viewed by 17245 | Submission Open
Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 14003 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by and
submission deadline 31 May 2026 | 4 articles | Viewed by 12907 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity
(This special issue belongs to the Section Molecular Medicine)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 7987 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 31 May 2026 | 1 articles | Viewed by 6605 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
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