Special Issue "Recent Advances in p53"
Deadline for manuscript submissions: closed (31 May 2020).
Interests: tumor biology; p53; HIPK2; molecular oncology; apoptosis; autophagy; resistance to therapies; solid tumors
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Special Issue in Biomolecules: Recent Advances in p53 2.0
This Special Issue is about p53, one of the most intensively studied tumor suppressor proteins that, in some circumstances, can acquire oncogenic function. Since its discovery, many cellular functions have been ascribed to p53, such as transcription regulation and signalling to apoptosis, involvement in the response to stress, senescence, DNA repair, metabolism, immunity, epigenetic regulation. Perturbation of p53 signalling pathways is required for the development of most cancers, and studies about the restoration or reactivation of p53 function have recently showed significant therapeutic benefit. Over half of all human cancers demonstrate alterations in p53 that not only attenuate or eliminate its tumor suppressor function but also can result in the gain of a novel transforming function, contributing to cancer progression. Much knowledge still needs to be acquired about the multiple facets of this intriguing protein. Here, we welcome papers describing recent advances in understanding p53 function and dysfunction, with an emphasis on novel molecules targeting p53 reactivation for translational purposes.
Prof. Gabriella D’Orazi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Small molecules
- Tumor suppressor
- Tumor–host interaction
- Targeted therapies
- Tumor microenvironment (TME)