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Biomolecules
Special Issues
Evaluation and Formulation of Bioactive Terpenes
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Evaluation and Formulation of Bioactive Terpenes

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6486

Special Issue Editors

Prof. Dr. Valdir Florencio Da Veiga Junior

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Guest Editor
Instituto Militar de Engenharia, Rio de Janeiro, Brazil
Interests: bioeconomy; natural products; phytochemistry; green chemistry; sustainability
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Letícia Scherer Koester

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Guest Editor
Pharmaceutical Sciences Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
Interests: nanoemulsions; skin delivery; controlled drug delivery; essential oils; solid dispersions
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ádley Antonini Neves de Lima

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Guest Editor
Department of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal, Brazil
Interests: pharmaceutical technology; drug delivery systems; nanotechnology; natural products; essential oils
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of the previous Special Issue “Evaluation and Formulation of Bioactive Terpenes”.

Terpenes are very bioactive natural products. They are commonly found in extracts from plants, animals, and microorganisms, mainly in essential oils and oleoresins. The issue will share a panorama of growing research concerning the encapsulation of either terpenes or the essential oils containing them in different nanostructure systems— polymeric, lipidic, or molecular complexes— with a view to obtaining chemical protection, improved bioefficacy, and permeation-enhancing ability, among other benefits.

This second Special Issue will continue to focus on the importance of the evaluation and formulation of bioactive natural products, which will be explored further. We welcome research and review articles focused on the biological assessment of bioactive natural products, upscaling the isolation and concentration of bioactive natural products, and formulation strategies, mainly using nanotechnological approaches.

Prof. Dr. Valdir Florencio Da Veiga Junior
Prof. Dr. Letícia Scherer Koester
Prof. Dr. Ádley Antonini Neves de Lima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • formulations
  • nanotechnology
  • cyclodextrins
  • protection
  • permeation
  • bioactive
  • natural products

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Published Papers (2 papers)

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Research

19 pages, 4573 KB  
Article
Innovative Strategy for Aroma Stabilization Using Green Solvents: Supercritical CO2 Extracts of Satureja montana Dispersed in Deep Eutectic Solvents
by Jelena Vladić, Strahinja Kovačević, Krunoslav Aladić, Stela Jokić, Sanja Radman, Sanja Podunavac-Kuzmanović, Ana Rita C. Duarte and Igor Jerković
Biomolecules 2023, 13(7), 1126; https://doi.org/10.3390/biom13071126 - 14 Jul 2023
Cited by 7 | Viewed by 2683
Abstract
The aim of this work was to establish the potential of natural deep eutectic solvents (NADES) for the stabilization of aroma volatile organic compounds from a natural source. Satureja montana was used as a source of volatile components, as it is rich in [...] Read more.
The aim of this work was to establish the potential of natural deep eutectic solvents (NADES) for the stabilization of aroma volatile organic compounds from a natural source. Satureja montana was used as a source of volatile components, as it is rich in terpenes of great commercial and biological importance, such as carvacrol, thymol, and thymoquinone, among others. Supercritical CO2 was used to extract the lipophilic fraction of S. montana, which was further directly dispersed in NADES. The stabilizing capacity of seven different NADES based on betaine and glycerol was analyzed. The stability of the components in NADES was monitored by analyzing the headspace profile during 6 months of storage at room temperature. The changes in the headspace profile over time were analyzed by using different statistical and chemometric tools and the Wilcoxon matched pair test. It was determined that alterations over time occurred such as degradation and oxidation, and they were the most prominent in the control. In addition, the indicator of decreased stability of the control was the formation of the new compounds that could compromise the quality of the product. In the stabilized NADES samples, the changes were significantly less prominent, indicating that the NADES had a stabilizing effect on the volatile compounds. According to Wilcoxon matched pair test, the most efficient stability was achieved by using betaine/ethylene glycol, glycerol/glucose, and betaine/sorbitol/water. Therefore, by applying two green solvents, a sustainable approach for obtaining pure and high-quality S. montana extracts with extended stability at room temperature was established. Full article
(This article belongs to the Special Issue Evaluation and Formulation of Bioactive Terpenes)
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22 pages, 4327 KB  
Article
Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil
by Olga A. Krasnova, Vladislav V. Minaychev, Vladimir S. Akatov, Roman S. Fadeev, Anatoly S. Senotov, Margarita I. Kobyakova, Yana V. Lomovskaya, Alexey I. Lomovskiy, Alyona I. Zvyagina, Kirill S. Krasnov, Yuriy V. Shatalin, Nikita V. Penkov, Vitaly K. Zhalimov, Maxim V. Molchanov, Yuliya A. Palikova, Arkady N. Murashev, Eugeny I. Maevsky and Irina S. Fadeeva
Biomolecules 2023, 13(7), 1053; https://doi.org/10.3390/biom13071053 - 29 Jun 2023
Cited by 1 | Viewed by 3109
Abstract
Turpentine oil, owing to the presence of 7–50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition of turpentine oil to squalene emulsions can increase their effectiveness, thereby reducing the concentration of [...] Read more.
Turpentine oil, owing to the presence of 7–50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition of turpentine oil to squalene emulsions can increase their effectiveness, thereby reducing the concentration of expensive and possibly deficient squalene, and increasing its stability and shelf life. In this study, squalene emulsions were obtained by adding various concentrations of turpentine oil via high-pressure homogenization, and the safety and effectiveness of the obtained emulsions were studied in vitro and in vivo. All emulsions showed high safety profiles, regardless of the concentration of turpentine oil used. However, these emulsions exhibited dose-dependent effects in terms of both efficiency and storage stability, and the squalene emulsion with 1.0% turpentine oil had the most pronounced adjuvant and cytokine-stimulating activity as well as the most pronounced stability indicators when stored at room temperature. Thus, it can be concluded that the squalene emulsion with 1% turpentine oil is a stable, monomodal, and reliably safe ultradispersed emulsion and may have pleiotropic effects with pronounced immunopotentiating properties. Full article
(This article belongs to the Special Issue Evaluation and Formulation of Bioactive Terpenes)
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