Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Iron in Human Diseases
edited by Margherita Correnti
submission deadline 30 Nov 2025 | 3 articles | Viewed by 1557 | Submission Open
Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Biomarkers for Neurodegenerative Disorders: From Bench to Bedside
edited by George P. Paraskevas
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1442 | Submission Open
Keywords: dementia; Alzheimer’ s disease; frontotemporal dementia; dementia with Lewy bodies; parkinsonism; tau protein; TDP-43; α -synuclein; Tau-PET; amyloid-PET
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Molecular Research of Neurological and Psychiatric Disorders
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1332 | Submission Open
Keywords: molecular biology; neurodegenerative disorders; psychiatry; biomarkers; therapeutic targets
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advanced Research on Genitourinary Cancer
edited by Jue Wang
submission deadline 30 Nov 2025 | 2 articles | Viewed by 948 | Submission Open
Keywords: genitourinary (GU) cancer; prostate; bladder; kidney; and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular and Translational Medicine)
Neurodevelopmental and Neuropsychiatric Disorders in Animal Models
edited by Yael Abreu-Villaça
submission deadline 30 Nov 2025 | 1 articles | Viewed by 879 | Submission Open
Keywords: mood disorder; mental disorder; substance use disorder; autism spectrum disorder (ASD); attention-deficit/hyperactive disorder (ADHD); depression and anxiety disorders; schizophrenia; bipolar disorder; epilepsy; eating disorders
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Reproductive Endocrinology and Fertility: From Bench to Bedside
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 768 | Submission Open
Keywords: reproductive health; reproductive system diseases; hormonal regulation; infertility; reproductive dysfunction; reproductive genetics; reproductive physiology; assisted reproductive technologies
(This special issue belongs to the Section Molecular and Translational Medicine)
Periodontal Disease and Periodontal Tissue Regeneration—Second Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 681 | Submission Open
Keywords: periodontal diagnosis; periodontal immunology; periodontal microbiology; periodontal tissue regeneration; tissue engineering
(This special issue belongs to the Section Biomedical Engineering and Materials)
State-of-the-Art Endocrine Cancer Biology and Oncology
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 618 | Submission Open
Keywords: thyroid and parathyroid tumors; adrenal tumors (hormonally active and inactive; ACC); neuroendocrine tumors (NEN); pituitary neuroendocrine tumors (PiNETs)
(This special issue belongs to the Section Cancer Biology and Oncology)
Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches
edited by Yanyun Gao
submission deadline 30 Nov 2025 | Viewed by 553 | Submission Open
Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy
edited by , Ednei Luiz Antonio, Gianna Móes de Albuquerque-Pontes and Luis Felipe Neves dos Santos
submission deadline 30 Nov 2025 | 1 articles | Viewed by 482 | Submission Open
Keywords: cardiomyopathy; cardiac remodeling; heart disease; heart failure; mechanisms; new therapies; targeted therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Non-Invasive Brain Stimulation Techniques and Their Application in the Study of Cognitive Function Physiology and Neuro-Psychiatric Rehabilitation
edited by , and Andrea Stefano Moro
submission deadline 30 Nov 2025 | 1 articles | Viewed by 469 | Submission Open
Keywords: non-invasive brain stimulation; neurophysiology; cognitive function; depression; schizophrenia  
(This special issue belongs to the Section Molecular and Translational Medicine)
Neurodegeneration No More: Cutting-Edge Technologies and Therapies in the Evolution of Neurodegenerative Disease Management—2nd Edition submission deadline 30 Nov 2025 | Viewed by 463 | Submission Open
Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Phenotypes and Endotypes in Interstitial Lung Diseases—Second Edition
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 362 | Submission Open
Keywords: interstitial lung diseases (ILDs); heterogeneity; pathogenesis; progressive pulmonary fibrosis (PPF); molecular biomarkers
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies submission deadline 30 Nov 2025 | Viewed by 344 | Submission Open
Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Animal Models for Neurological Disease Research
edited by
submission deadline 30 Nov 2025 | Viewed by 325 | Submission Open
Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways
(This special issue belongs to the Section Molecular and Translational Medicine)
The Interplay Between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 318 | Submission Open
Keywords: miRNA; neurodegenerative diseases; mitochondrial dysfunction; aging; gene expression
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Molecular Mechanisms of Normal and Malignant Hematopoiesis: 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 297 | Submission Open
Keywords: hematopoietic stem cells; self-renewal; differentiation; hematological malignancies; molecular mechanisms; genetic factors; epigenetic factors; transcriptional regulation; HSC niche; targeted therapy
(This special issue belongs to the Section Molecular and Translational Medicine)
Innovative Biomaterials and Advanced Techniques for Bone Regeneration Applications
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 296 | Submission Open
Keywords: biomaterials; bone regeneration; osteointegration; 3D printing; biomimetic design
(This special issue belongs to the Section Biomedical Engineering and Materials)
Feature Reviews in Cancer Genetics and Epigenetics
edited by
submission deadline 30 Nov 2025 | Viewed by 213 | Submission Open
Keywords: cancer genetics; epigenetics; DNA methylation; histone modifications; non-coding RNAs; tumor heterogeneity; drug resistance; biomarkers; precision oncology; personalized therapy
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Advances in Genomics and Bioinformatics of Human Disease
edited by Sankarasubramanian Jagadesan
submission deadline 30 Nov 2025 | Viewed by 203 | Submission Open
Keywords: genomics; bioinformatics; precision medicine; single-cell RNA sequencing; genetic variations; cellular heterogeneity; AI/ML; pathogenicity prediction
(This special issue belongs to the Section Molecular and Translational Medicine)
Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 199 | Submission Open
Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis
(This special issue belongs to the Section Molecular and Translational Medicine)
Diagnosis, Management and Treatment of Rheumatoid Arthritis
edited by Yong Feng
submission deadline 30 Nov 2025 | Viewed by 181 | Submission Open
Keywords: rheumatoid arthritis; autoimmune disorder; synovial inflammation; genetic factors; signaling pathway; targeted therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Second Edition
edited by and Dragos Cozma
submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; thyroid dysfunction; hormonal alterations; endothelial dysfunction; coronary artery disease; hypertension; peripheric arterial disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
The Role of HOX Genes in Particular Cancers
edited by
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: HOX genes; anti-cancer drugs; cell memory program; epigenetic regulation
(This special issue belongs to the Section Cancer Biology and Oncology)
Hepatocellular Carcinoma: From Pathophysiology to Therapeutic Approaches Treatment
edited by
submission deadline 30 Nov 2025 | Viewed by 159 | Submission Open
Keywords: hepatocellular carcinoma; pathophysiology; therapeutic interventions
(This special issue belongs to the Section Cancer Biology and Oncology)
Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome
edited by Hermann L. Müller
submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open
Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae
(This special issue belongs to the Section Cancer Biology and Oncology)
Recent Advances in Lymphoma: Second Edition submission deadline 30 Nov 2025 | Viewed by 137 | Submission Open
Keywords: lymphoma; cancer; gene expression; mutational analysis; target; therapy; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Exercise-Induced Physiological Responses: From Oxidative Stress to DNA Alterations
edited by
submission deadline 30 Nov 2025 | Viewed by 136 | Submission Open
Keywords: exercise-induced oxidative stress; reactive oxygen species (ROS); molecular adaptations to exercise; epigenetic modifications in exercise; DNA damage and repair; cell-free DNA; extracellular DNA; inflammation and exercise; DNA alterations
(This special issue belongs to the Section Cell Biology and Pathology)
Mitochondrion-Targeting Agents for Tumor Therapy
edited by
submission deadline 30 Nov 2025 | Viewed by 127 | Submission Open
Keywords: mitochondria; cell signaling; apoptosis; cancer therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Application of New Technologies in Drug Delivery
edited by Venkata Raman Kallakunta
submission deadline 30 Nov 2025 | Viewed by 114 | Submission Open
Keywords: drug delivery; new technologies; nanoparticles; self-emulsifying drug delivery systems (SEDDSs); hot melt extrusion (HME); gene editing; 3D printing
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Molecular and Histopathological Background of Diabetic Neuropathy
edited by
submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open
Keywords: diabetic neuropathy; insulin; hyperglycaemia; peripheral neuropathy; autonomic neuropathy; proximal neuropathy; enteric neuropathy; mononeuropathy
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Therapeutic Resistance in Oral Cancer: Mechanisms, Biomarkers, and Novel Strategies to Restore Treatment Responses submission deadline 30 Nov 2025 | Viewed by 107 | Submission Open
Keywords: oral cancer; OSCC; chemotherapy; radiotherapy; immunotherapy; therapeutic resistance; HNSCC; biomarker; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
New Insights in Radiotherapy: Bridging Radiobiology and Oncology
edited by and I-Tsang Chiang
submission deadline 30 Nov 2025 | Viewed by 101 | Submission Open
Keywords: tissue-sparing effect; bystander effect; factors that affect radiation-induced lethality; radiation-induced abscopal effect; mechanisms that enhance tissue radiosensitivity; synergistic effect from radiotherapy and immunotherapy; regulatory perspectives on medical radiation safety
(This special issue belongs to the Section Cancer Biology and Oncology)
Coronary Artery Disease: From Pathophysiology to Therapeutic Strategies submission deadline 30 Nov 2025 | Viewed by 99 | Submission Open
Keywords: pathophysiological concept of coronary artery disease; coronary microvascular dysfunction; chronic coronary syndrome; acute coronary syndrome; post-acute coronary syndrome with heart failure; diagnostics in coronary artery disease; therapeutic strategies in CAD; revascularization
(This special issue belongs to the Section Cell Biology and Pathology)
Inflammatory Bowel Diseases: New Diagnostic and Therapeutic Approaches—Second Edition submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open
Keywords: bowel inflammation; Crohn’ s disease; endoscopy; inflammatory bowel disease; targeted therapy; ulcerative colitis
(This special issue belongs to the Section Immunology and Immunotherapy)
Urogenital Cancers: New Molecular and Translational Aspects on Carcinogenesis and Treatments (2nd Edition) submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open
Keywords: prostate cancer; bladder cancer; renal cell carcinoma; testicular cancer; ovarian cancer; endometrial cancer; carcinogenesis; biomarkers; early diagnosis; upper urinary tract tumors; diagnosis; treatment; environmental factors; diet
(This special issue belongs to the Section Cancer Biology and Oncology)
Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance
edited by
submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open
Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Novel Biomaterials and Tissue Engineering Approaches in Periodontal Regeneration
edited by
submission deadline 30 Nov 2025 | Viewed by 84 | Submission Open
Keywords: periodontium; tissue engineering; regenerative medicine; biomaterials; bioprinting; mesenchymal stem/stromal cells; senescence; aging; advanced therapeutics
(This special issue belongs to the Section Biomedical Engineering and Materials)
Advances in Molecular Research on Physical Activity, Sleep and Cognitive Function
edited by
submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: physical activity; sleep; cognitive function; molecular mechanisms; neuroplasticity; oxidative stress; inflammation; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Pathogenesis, Diagnosis, and Treatment of Prostate Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open
Keywords: prostate cancer  ; molecular imaging; PET/CT; PSMA (prostate-specific membrane antigen); theranostics; radiopharmaceutical therapy; diagnosis and staging; radiology; targeted therapy; tumor microenvironment
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Neurophysiology and the Treatment of Parkinson’s Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open
Keywords: movement disorders; hypokinetic movement disorders; Parkinson’ s disease; levodopa; treatment; neurophysiology; neuroplasticity; motor learning
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Clinical Advances in Hepatocellular Carcinoma
edited by Mohamed A. Abd El Aziz
submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation
(This special issue belongs to the Section Cancer Biology and Oncology)
Animal Models of Human Pathology: Revision, Relevance and Refinements (4th Edition)
edited by
submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: animal models; biomarkers; human disease; pathology; translation; mechanisms; nephrology; gastroenterology; urology; neuroscience; cancer; experimental design; reproducibility; refinements
(This special issue belongs to the Section Molecular and Translational Medicine)
Cardiomyopathies and Heart Failure: Charting the Future—2nd Edition
edited by Ali Amr
submission deadline 30 Nov 2025 | Viewed by 68 | Submission Open
Keywords: cardiomyopathies; heart failure; risk stratification; management of cardiomyopathies; cardiac imaging; telemedicine
(This special issue belongs to the Section Cell Biology and Pathology)
Structure-Based Drug Molecule Design and Organic Synthesis
edited by
submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open
Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Small Intestinal Bacterial Overgrowth and Antimicrobial submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open
Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances of Microbiome in Human Cancers
edited by
submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open
Keywords: human microbiome; gut microbiota; tumor-resident microbes; translational research; biomarkers; computational biology
(This special issue belongs to the Section Cancer Biology and Oncology)
The Preparation of an Exosome/Liposomal Nano-Drug Delivery System and Its Application in the Treatment of Inflammatory Bowel Disease
edited by and
submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open
Keywords: exosomes; liposomes; nano-drug delivery systems; inflammatory bowel disease (IBD); targeted therapy; mucosal drug delivery; drug encapsulation; immunomodulation; nanomedicine; extracellular vesicles; personalized medicine
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Coronary Artery Disease: Current Evidence and Future Perspectives
edited by Tadateru Takayama
submission deadline 30 Nov 2025 | Viewed by 64 | Submission Open
Keywords: coronary artery disease; lipid-lowering therapy; residual risk; small dense LDL; lipoprotein(a); endothelial dysfunction; oxidative stress; inflammation; biomarkers; cardiovascular prevention
(This special issue belongs to the Section Molecular and Translational Medicine)
Engineering Extracellular Matrix (ECM)-Based Scaffold Biomaterials for Cancer Treatment
edited by
submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: extracellular matrix; biomaterials; immunomodulatory agents; cancer immunotherapy; sustained delivery; drug delivery; tumor modeling; 3D model; therapeutic response; decellularized ECM
(This special issue belongs to the Section Gene and Cell Therapy)
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