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Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research—2nd...
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Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 March 2026 | Viewed by 351

Special Issue Editor

Dr. Cristiana Bustea

E-Mail Website
Guest Editor
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
Interests: hypertension; clinical cardiology; heart failure; echocardiography; myocardial infarction; atherosclerosis; blood pressure; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Welcome to our Special Issue, entitled “Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research—2nd Edition”. Acute coronary syndrome (ACS) is a critical cardiovascular condition encompassing unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI). As a leading cause of morbidity and mortality worldwide, ACS demands an intricate understanding of its pathophysiology, risk factors, and evolving therapeutic approaches. This Special Issue aims to delve into the realms of basic and clinical research, offering a comprehensive exploration of ACS.

Through its collection of articles, this Special Issue aspires to illuminate the latest breakthroughs and critical findings that bridge the gap between fundamental research and clinical applications. Our aim is to provide unique perspectives on diagnostic modalities, novel therapeutic interventions, and emerging trends in ACS management. By fostering collaboration and disseminating knowledge, we hope to advance the field, providing clinicians, researchers, and healthcare professionals with valuable insights that can directly impact patient outcomes.

Join us on this enlightening journey by submitting manuscripts including original studies and reviews that will unravel the complexities of ACS and will improve our understanding and management of this significant cardiovascular challenge.

Dr. Cristiana Bustea
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndrome
  • cardiovascular morbidity
  • myocardial infarction
  • pathophysiology
  • diagnostic modalities
  • therapeutic interventions
  • translational research

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Related Special Issue

Published Papers (1 paper)

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Review

14 pages, 1032 KB  
Review
Thyrotoxicosis and the Heart: An Underrecognized Trigger of Acute Coronary Syndromes
by Larisa Anghel, Anca Diaconu, Laura-Cătălina Benchea, Cristina Prisacariu, Dragoș Viorel Scripcariu, Răzvan-Liviu Zanfirescu, Gavril-Silviu Bîrgoan, Radu Andy Sascău and Cristian Stătescu
Biomedicines 2025, 13(11), 2591; https://doi.org/10.3390/biomedicines13112591 - 23 Oct 2025
Viewed by 264
Abstract
Background: Thyrotoxicosis is a systemic condition with well-documented cardiovascular effects, but its role as a precipitant of acute coronary syndromes (ACS) is often overlooked. This review summarizes clinical cases and original studies from the last 20 years, describing ACS triggered by thyrotoxicosis. Methods: [...] Read more.
Background: Thyrotoxicosis is a systemic condition with well-documented cardiovascular effects, but its role as a precipitant of acute coronary syndromes (ACS) is often overlooked. This review summarizes clinical cases and original studies from the last 20 years, describing ACS triggered by thyrotoxicosis. Methods: Following PRISMA 2020 guidelines, we searched PubMed, Scopus, and Embase for reports published between 2004–2025. Only case reports and original articles were included. Data extracted included demographics, ECG findings, angiography results, thyroid function, etiology of hyperthyroidism, and outcomes. Results: A total of 35 cases were identified. The mean age was in the fourth decade of life, with a female predominance (57%, 20 out of 35). More than half of the patients presented with ST-segment elevation myocardial infarction (STEMI) or STEMI equivalents (21 out of 35; 60%). Electrocardiographic abnormalities most often involved anterior or inferior leads. Coronary angiography revealed normal vessels or diffuse vasospasm in 18 cases (51%), while thrombotic occlusion was observed in 4 cases (11%), spontaneous dissection in 2 cases (6%), and myocardial bridging in 3 cases (9%). The leading cause of thyrotoxicosis was Graves’ disease (≈65%), followed by painless thyroiditis, iatrogenic causes, and gestational hyperthyroidism. Thyroid storm was reported in approximately 20% of cases and was associated with malignant ventricular arrhythmias or sudden cardiac death. Conclusions: Thyrotoxicosis should be recognized as a rare but important trigger of ACS, especially in young patients without traditional risk factors. Pathophysiological mechanisms include coronary vasospasm, increased myocardial oxygen demand, and hypercoagulability. Early recognition may prevent unnecessary revascularization and optimize outcomes through integrated endocrine and cardiac management. Full article
(This article belongs to the Special Issue Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research—2nd Edition)
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