Skin Fibrosis and Cutaneous Wound Healing—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1008

Special Issue Editor


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Guest Editor
Department of Plastic and Reconstructive Surgery, Keio University Hospital, Tokyo 160-8582, Japan
Interests: fibroblasts; inflammation; fibrosis; cutaneous wound healing
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Special Issue Information

Dear Colleagues,

During the wound healing process, epithelialization is completed and remodeling of the extracellular matrix that makes up the granulation tissue occurs. Fibroblasts and leukocytes disappear from the granulation tissue formed during the proliferative phase, and collagen fibers are altered to form scar tissue. Granulation tissue contains large amounts of type III collagen, which diminishes during maturation and is replaced by type I collagen. Collagen polymerizes through cross-linking, increasing the support and tensile strength of the scar. If inflammation is prolonged during this period, fibroblasts do not decrease and collagen production continues, causing hypertrophic scars and keloids. The purpose of this Special Issue is to focus on inflammation and fibrosis and to explore their mechanisms.

Dr. Noriko Aramaki-Hattori
Guest Editor

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Keywords

  • fibroblasts
  • inflammation
  • fibrosis
  • cutaneous wound healing

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Published Papers (1 paper)

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Research

19 pages, 2616 KB  
Article
Exploring the Impact of Skin Care Routines on the Skin Microbiome and Possible Skin Disease Risk—A Pilot Study
by Kirti Dubli, Preethi Balasundaram, Rinku Chaudhari, Sarvesh Vettrivelan, Arman Borawake, Raman Kapoor, Igor Kovalchuk, Anmol Kapoor, Raja Singh and Minal Borkar Tripathi
Biomedicines 2025, 13(10), 2371; https://doi.org/10.3390/biomedicines13102371 - 27 Sep 2025
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Abstract
Background/Objectives: Unceasing exposure of skin and its microbiome to various external and internal factors influences its health. Any imbalance ensuing may result in dysbiosis and consequently skin diseases. Thus, it becomes critical to identify and recognize the influence of several factors on the [...] Read more.
Background/Objectives: Unceasing exposure of skin and its microbiome to various external and internal factors influences its health. Any imbalance ensuing may result in dysbiosis and consequently skin diseases. Thus, it becomes critical to identify and recognize the influence of several factors on the skin microbiome and various disorders associated with it. Methods: In the current investigation, we studied the skin microbiomes of 37 subjects using the next-generation shotgun sequencing method and compared them with 48 healthy subjects from the Human Microbiome Project (HMP). This work focused on the analysis of the impact of different skin care routines—use of sunscreen and moisturizers—on the skin microbiome and related skin diseases. Results: Differences were observed between the microbiomes of subjects who were using only moisturizer (p = 3.1 × 10−5) or moisturizer with sunscreen (p = 3.2 × 10−13) and those who did not use these products at all. We also observed differences in the skin microbiomes of males vs. females with respect to the use of moisturizer. The composition of the skin microbiomes of female participants showed a higher difference in diversity in comparison to males. The current investigation also found that usage of sunscreen might help in retaining skin-protecting species in the skin microbiome. Conclusions: This work allowed us to understand the impact of moisturizer and sunscreen on skin health. The present evaluation shall pave the way for personalized skin care product development. Full article
(This article belongs to the Special Issue Skin Fibrosis and Cutaneous Wound Healing—2nd Edition)
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