Molecular Mechanisms of Coronary Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 6
Special Issue Editors
Interests: heart development; epigenetics; genetics; chromatin; single-cell; bioinformatics; cardiovascular disease; 3D genome
Special Issue Information
Dear Colleagues,
Coronary artery disease (CAD) is predicted to continue as the worldwide leading cause of human mortality for at least the next two decades. Epidemiological and genome-wide studies have revealed hundreds of important environmental and genetic risk factors associated with CAD. Progress in defining the molecular mechanisms involved, however, has been hindered by the disease’s complexity. Over the past decade, the availability of new technologies, such as single-cell sequencing, multi-omics approaches, and CRISPR-modified mouse models, has resulted in a clearer understanding of the development of atherosclerotic plaque.
This Special Issue focuses on molecular mechanisms (cell fate transition and vascular remodeling, transcriptional and epigenetic regulations in the plaque, cytokines and signaling pathways, genetic risk factors, calcification, etc.) of CAD, aiming to improve our knowledge of the disease and provide insights for personalized medicine.
Dr. Quanyi Zhao
Dr. João P. Monteiro
Guest Editors
Manuscript Submission Information
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Keywords
- atherosclerosis
- coronary artery disease
- cell fate transition
- transcription
- epigenetics
- genetics
- cytokine
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