Impacts of Exercise, Nutrition, Obesity, Metabolism and Ageing on Regenerative Medicine and Their Applications in Tissue Engineering and Therapeutics

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 454

Special Issue Editor


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Guest Editor
1. Faculty of Pharmacy, Laval University, Québec, QC, Canada
2. Regenerative Medicine Axis, CHU de Québec-Université Laval Research Center, Québec, QC, Canada
Interests: metabolism; obesity; aging; exercise; bone/mineral disorders; nutrition/diet; therapeutics; bioengineering; skin replacement model/substitutes

Special Issue Information

Dear Colleagues,

Exercise, nutrition/diet, obesity, metabolism and ageing are key factors in both biological development, pathogenesis and disease prognosis.

These factors also influence each other, and some of them have similarities. For example, obesity and ageing share common features, including the cellular and molecular pathways involved and the impact they have as risk factors for a wide range of diseases and health problems. Common patterns of ageing and obesity at the molecular and epigenetic levels include mechanisms such as insulin resistance, abnormal liver glucose metabolism and DNA methylation.

In the context of regenerative medicine and related laboratory applications for tissue engineering, exercise, diet, obesity, metabolism and ageing have profound implications that should be explored to elucidate the underlying mechanistic pathways. With such understanding, we will be able to improve/develop new methods for research applications and develop potential tools to optimise some therapeutic approaches used in regenerative medicine.

With this in mind, we welcome submissions to this special issue on how factors related to exercise, diet/nutrition, obesity, metabolism and ageing affect regenerative medicine, including cell development, stem cells, tissue repair and degeneration. The application of such interactions is also an important part of this special issue. In particular, we aim to highlight how knowledge of such interactions can be applied to improve the practice and conditions of tissue bioengineering, as well as therapeutic approaches and implications.

Dr. Abdelaziz Ghanemi
Guest Editor

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Keywords

  • obesity
  • exercise
  • nutrition (diet)
  • obesity
  • metabolism
  • ageing
  • regenerative medicine
  • tissue engineering
  • therapeutics

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Published Papers (1 paper)

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4 pages, 162 KiB  
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Therapeutic Potential of Exercise-Induced SPARC in Bone Health?
by Abdelaziz Ghanemi, Mayumi Yoshioka and Jonny St-Amand
Biomedicines 2025, 13(4), 945; https://doi.org/10.3390/biomedicines13040945 - 12 Apr 2025
Viewed by 244
Abstract
Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, [...] Read more.
Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. Such properties can be explored in conditions including bone fractures or requiring bone regenerative adjuvants. In addition, these properties can also be applied in basic research such as building an environment more suitable for cellular proliferation or optimizing in vitro conditions. Full article
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