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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Dysfunction: From a Pathophysiological Mechanism to a Potential Therapeutic Target—3rd Edition

edited by

Pasquale Ambrosino

and

Guido Grassi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2890 | Submission Open

Keywords: endothelial function; arterial stiffness; vascular medicine; cardiovascular risk; nitric oxide; reactive oxygen species; interleukins; inflammation; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research on Skeletal Muscle Metabolism

edited by Lorenzo Sanesi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2655 | Submission Open

Keywords: energy metabolism; mebabolic signaling pathways; homeostasis; myokines; aging; atrophy; muscle metabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Research in Ocular Pathology

edited by

Sorin Lucian Bolintineanu

and

Laura Andreea Ghenciu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2654 | Submission Open

Keywords: molecular pathology; ocular diseases; biomarkers; diabetic retinopathy; glaucoma; age-related macular degeneration; thyroid eye disease; inflammatory pathways; oxidative stress; angiogenesis; neurodegeneration; gene therapy; cell therapy; precision medicine; ocular imaging

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Cardiovascular Remodeling: Molecular Mechanisms and Therapeutic Targets

edited by

Elena Kaschina

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2557 | Submission Open

Keywords: cardiac remodeling; vascular remodeling; ageing; pathogenesis; molecular mechanisms; diagnostics; therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Biotechnology in the Treatment and Management of Hearing Loss

edited by

Alessandro Castiglione

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2372 | Submission Open

Keywords: hearing loss; gene therapy; regenerative medicine; cochlear implants; nanotechnology stem cell therapy; CRISPR-Cas9; auditory prosthetics; artificial intelligence; auditory regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Mechanisms and Therapeutic Approaches for Hepatocellular Carcinoma

edited by Lanqi Gong,

Xinyuan Guan

and Yu Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2308 | Submission Open

Keywords: hepatocellular carcinoma; HCC diagnosis and prognosis; HCC mechanisms; therapeutic resistance; immunotherapy; targeted therapy; personalized medicine; drug development; clinical trials; translational studies

(This special issue belongs to the Section Cancer Biology and Oncology)

Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy

edited by

Angela Rizzi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2288 | Submission Open

Keywords: acute urticaria; chronic urticaria; pathogenesis; mast cells; biomarkers; diagnosis; biologicals

(This special issue belongs to the Section Molecular and Translational Medicine)

Diabetes: Comorbidities, Therapeutics and Insights (3rd Edition)

edited by

Tomislav Bulum

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2157 | Submission Open

Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Autophagy, Apoptosis and Cancer: 2025 Update

edited by

Md Ataur Rahman

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1976 | Submission Open

Keywords: autophagy; apoptosis; glioblastoma; hypoxia-inducible factors (HIFs); female fertility and ovarian cancer; nanoparticle-based drug delivery; bioactive natural products

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Oral Medicine—2nd Edition

edited by

Arkadiusz Dziedzic

and

Robert Kubina

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1684 | Submission Open

Keywords: oral medicine; oral manifestations of systemic conditions; drug-induced lesions; oral pathologies; head and neck cancer; autoimmune; oral lesions; bisphosphonates; systemic pharmacotherapy; infectious diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis and Treatment of Mycobacterium Tuberculosis Infection

edited by Sajid Nadeem

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1651 | Submission Open

Keywords: mycobacterium tuberculosis; pathogenesis; host-directed therapy; inflammation; necrosis; innate and adaptive immunity

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Microcirculation, Thrombosis, and Inflammation in Peripheral Artery Disease and in the Brain

edited by

Patricia Pia Wadowski

and

Henriette Löffler-Stastka

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1623 | Submission Open

Keywords: microcirculation; thrombosis; inflammation; peripheral artery disease; brain

(This special issue belongs to the Section Molecular and Translational Medicine)

Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition

edited by

Aline Yen Ling Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1545 | Submission Open

Keywords: induced pluripotent stem cells; iPSC generation; somatic reprogramming; iPSC-derived cells; cell therapy; exosome therapy; therapeutic application; drug screening

(This special issue belongs to the Section Cell Biology and Pathology)

Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches, 2nd Edition

edited by

Marie-Lise Maddelein

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1363 | Submission Open

Keywords: neurodegenerative diseases; neurons; mechanism

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Congenital Heart Disease: Diagnosis, Treatment and Prognosis

edited by

Gaetano Thiene

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1324 | Submission Open

Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

Application of Artificial Intelligence in Biomedicines

edited by

Raffaele Pugliese

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: artificial intelligence; generative artificial intelligence; precision medicine; clinical decision support; drug discovery; personalized therapy; trustworthy AI

(This special issue belongs to the Section Molecular and Translational Medicine)

Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches

edited by

Giorgio Sodero

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1241 | Submission Open

Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Precision Cancer Therapy

edited by

Yongheng Chen

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1049 | Submission Open

Keywords: personalized cancer therapy; targeted therapy; immunotherapy; cancer genomics; cancer biomarker; liquid biopsy; CAR-T cell therapy; kinase inhibitor; combination therapy; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 942 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 28 Feb 2026 | Viewed by 563 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Peptide Therapeutic Approaches for Cancer Treatment

edited by

Prakash Lingasamy

and

Vijayachitra Modhukur

submission deadline 28 Feb 2026 | Viewed by 490 | Submission Open

Keywords: peptide therapeutics; cancer treatment; drug delivery systems; molecular imaging; bioinformatics; machine learning and artificial intelligence (AI); therapeutic targeting; peptide– drug conjugates; personalized medicine; immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Gastric Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatment

edited by Sharona B. Ross

submission deadline 28 Feb 2026 | 1 articles | Viewed by 435 | Submission Open

Keywords: gastric cancer; tumor microenvironment; molecular mechanism; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Adipokines (3nd Edition)

edited by

Christa Büchler

submission deadline 28 Feb 2026 | Viewed by 426 | Submission Open

Keywords: adiponectin; receptor; agonist; biomarker; inflammation; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Primary and Relapsed Ovarian Cancer

edited by Cornelia Bachmann

submission deadline 28 Feb 2026 | Viewed by 359 | Submission Open

Keywords: ovarian cancer; relapse; BRCA; genetics; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets

edited by Jude Taylor

submission deadline 28 Feb 2026 | Viewed by 344 | Submission Open

Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Role of Environmental Pollutants in Cancer and Chemoresistance

edited by

Fabio Altieri

and

Margherita Eufemi

submission deadline 28 Feb 2026 | Viewed by 343 | Submission Open

Keywords: environmental pollutants; cancer cells; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances of Amyloid-β Dynamics in Health and Diseases

edited by

Rahat Ullah

submission deadline 28 Feb 2026 | Viewed by 338 | Submission Open

Keywords: Alzheimer’ s disease (AD); amyloid-β clearance; brain and periphery; cerebral amyloid angiopathy (CAA)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Innovations in Nanomedicine for Disease Management

edited by Anna Valentino and

Raffaele Conte

submission deadline 28 Feb 2026 | Viewed by 312 | Submission Open

Keywords: nanomedicine; nanoparticles; smart drug delivery; personalized medicine; minimally invasive treatments; gene therapy; regenerative medicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders

edited by

Xuming Zhu

submission deadline 28 Feb 2026 | Viewed by 247 | Submission Open

Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Biomedical Engineering for the Elderly

edited by

Siti Anom Ahmad

submission deadline 28 Feb 2026 | Viewed by 189 | Submission Open

Keywords: biomedical engineering; gerontechnology; artificial intelligence in healthcare; digital health; physiological signal processing; human– machine interaction; rehabilitation engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Cancer Treatment

edited by

Vlasios Karageorgos

and

George Liapakis

submission deadline 28 Feb 2026 | Viewed by 167 | Submission Open

Keywords: targeted therapy; bio-conjugates; biologic agents; precision oncology; personalized cancer treatment; biomarker-guided therapy; cancer drug development; biopharmaceuticals

(This special issue belongs to the Section Cancer Biology and Oncology)

Cannabinoids in Therapeutics: Mechanisms, Signaling Pathways and Personalized Treatment Strategies

edited by

Jan Rožanc

and

Uroš Maver

submission deadline 28 Feb 2026 | Viewed by 167 | Submission Open

Keywords: cannabinoids; endocannabinoid system; cancer; pain; inflammation; personalized medicine; receptor signaling; therapeutic development; drug delivery; pharmacogenomics; systems pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Advances in Wound Healing and Skin Regeneration

edited by

Bingrong Zhou

and Siqi Fu

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: wound healing; skin regeneration; biomaterials; stem cell therapy; tissue engineering; bioactive dressings; 3D bioprinting; growth factors; chronic wounds; regenerative medicine

Current Challenges and Future Trends in Intracranial Aneurysms: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Zhongsong Shi and

Aichi Chien

submission deadline 28 Feb 2026 | Viewed by 137 | Submission Open

Keywords: intracranial aneurysm; subarachnoid hemorrhage; inflammation; immune; smooth muscle cell; endothelial dysfunction; hemodynamic forces; biomarkers; neuroimaging; non-coding RNA; multi-omics; endovascular treatment; computational fluid dynamic

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Glioblastoma: From Pathology to Novel Therapeutic Approaches

edited by Carlen A. Yuen

submission deadline 28 Feb 2026 | Viewed by 136 | Submission Open

Keywords: glioblastoma; EGFR; TERT; +7/-10; CAR T-cell therapy; immunotherapy; GammaTile® ; LITT

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment

edited by

Guanhu Yang

submission deadline 28 Feb 2026 | Viewed by 128 | Submission Open

Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives

edited by

Shuchao Wang

submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open

Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by

Toomas Toomsoo

submission deadline 28 Feb 2026 | Viewed by 119 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Innovative Strategies for the Diagnosis and Treatment of Sarcopenia and Osteoporosis

edited by Wei-Bin Hsu and

Meng-Huang Wu

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: sarcopenia; osteoporosis; healthy aging; bone strength; muscle health; fracture prevention; pharmacological therapies; nutritional support; exercise rehabilitation

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Pulmonary Fibrosis

edited by

Mari Ozaki

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: pulmonary fibrosis; interstitial lung disease; antifibrotic therapy; precision medicine; imaging diagnostics; novel therapeutics; pathobiology; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Novel Insight into Human Reproductive Medicines

edited by

Bo Huang

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: IVF; oocyte; sperm; clinical outcome; embryo; ovulation induction; fertilization; PGT

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders

edited by

Qingkun Liu

and

Xin-An Liu

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut– brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology

edited by Sevastiani Antonouli and

Valentina Di Nisio

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges

(This special issue belongs to the Section Gene and Cell Therapy)

Drug Resistance and Novel Targets for Cancer Therapy—Third Edition

edited by

Bruno Kaufmann Robbs

and

Fernando de Carvalho da Silva

submission deadline 28 Feb 2026 | Viewed by 92 | Submission Open

Keywords: cancer; drug resistance; targeted therapy; conventional chemotherapy; natural products; molecular targets; cancer hallmarks; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Diagnosis and Therapeutic Strategies in Intraocular Inflammation—Second Edition

edited by

Uwe Pleyer

submission deadline 28 Feb 2026 | Viewed by 92 | Submission Open

Keywords: biomarker; diagnosis; immune pharmacology; immune regulation; immune system; infection; uveitis; therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Neurotrauma: Mechanisms, Pathways, and Emerging Therapeutic Interventions, 2nd Edition

edited by Kevin Pierre and

Brandon Lucke-Wold

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: neurotrauma; traumatic brain injury; spinal cord injury; inflammation; oxidative stress; excitotoxicity; diagnostic biomarkers; imaging techniques; neuroprotection; neurogeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches

edited by

Santarsiero Anna

Vittoria Infantino

and Paolo Convertini

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Neuroimmunology and Neurological Infection

edited by

Mariya Ivanovska

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: neuroimmunology; neurological infections; immune-mediated diseases; neurodegeneration; biomarkers; immunotherapy; neuroinflammation; clinical neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Technologies in Liquid Biopsy of Cancers

edited by Lingdi Yin

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

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