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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Biomarkers and Technologies in the Research and Diagnosis of Human Diseases: Second Edition

edited by

Benjamin M. Liu

submission deadline 31 Oct 2025 | Viewed by 224 | Submission Open

Keywords: pathology; diseases; biomarkers; diagnosis; novel technologies

(This special issue belongs to the Section Immunology and Immunotherapy)

PET and SPECT Imaging for the Diagnosis of Neurodegenerative Diseases

edited by Paulina Gonzalez and

Carlo Colosimo

submission deadline 31 Oct 2025 | Viewed by 198 | Submission Open

Keywords: neurodegenerative diseases; PET imaging and diagnosis; neurological disorders; clinical PET imaging; positron emission tomography

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by

Gennaro Nappo

and

Niccola Funel

submission deadline 31 Oct 2025 | Viewed by 194 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; treatment pancreatic cancer; chemotherapy pancreatic cancer; radiotherapy pancreatic cancer; pancreatic cancer biology; PDAC preclinical model; biomolecular markers; theragnostic molecules; target therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Insights and Translational Approaches in Musculoskeletal Disorders

edited by Priyanka Kushwaha

submission deadline 31 Oct 2025 | Viewed by 174 | Submission Open

Keywords: musculoskeletal disorders; osteoarthritis; rheumatoid arthritis

(This special issue belongs to the Section Molecular and Translational Medicine)

Poly-Pharmacological Effects and Mechanisms of Phytochemicals

edited by

Jiawen Shou

submission deadline 31 Oct 2025 | Viewed by 170 | Submission Open

Keywords: phytochemicals; natural products; poly-pharmacology; novel application; research updates on phytochemicals

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

The Molecular Mechanisms of Hearing, Balance and Deafness

edited by

Francisco J. del Castillo

submission deadline 31 Oct 2025 | Viewed by 160 | Submission Open

Keywords: hearing; balance; deafness; molecular mechanisms; genetics; transcriptomics

(This special issue belongs to the Section Molecular and Translational Medicine)

Treatment of HIV Infection: Strategies, New Drugs and Drug Metabolism

edited by

Salvatore Martini

submission deadline 31 Oct 2025 | Viewed by 142 | Submission Open

Keywords: HIV; long-acting; efficacy; tolerability; adherence

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Musculoskeletal Diseases: From Molecular Basis to Therapy—3th Edition

edited by

Elisa Belluzzi

and

Assunta Pozzuoli

submission deadline 31 Oct 2025 | Viewed by 124 | Submission Open

Keywords: musculoskeletal diseases; bone cancer; soft tissue cancer; bone metastasis; natural compounds; anticancer drugs; osteoarthritis; joint tissues; biomarkers; inflammation; microRNAs; exosomes

(This special issue belongs to the Section Molecular and Translational Medicine)

The Human Proteinomics in Disease, Diagnostics and Translation into Precision Medicine: Current Status and Future Prospects—2nd Edition

edited by

M. Walid Qoronfleh

submission deadline 31 Oct 2025 | Viewed by 103 | Submission Open

Keywords: proteomics; human proteome; systems biology; precision medicine; biomarker(s); disease pathogenesis; diagnostics; mass spectrometry; tandem mass spectrometry; LC-MS/MS; peptides and proteins; multiplex protein analysis; protein network; protein– protein interaction; splice variants; post-translational modifications; omics analysis; data integration; bioinformatics; artificial intelligence; deep learning

(This special issue belongs to the Section Molecular and Translational Medicine)

Photodynamic Therapy (4th Edition)

edited by

Stefano Bacci

submission deadline 31 Oct 2025 | Viewed by 100 | Submission Open

Keywords: antimicrobial photodynamic treatment; chronic wounds; inflammatory dermatoses; photobiology photochemistry; photochemotherapy; photosensitizing agents; skin cancer; oral mucosa

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications

edited by

Stefano Cacciatore

and

Emanuele Marzetti

submission deadline 31 Oct 2025 | Viewed by 98 | Submission Open

Keywords: aging; age-related diseases; cellular senescence; mitochondrial dysfunction; inflammation and oxidative stress; biomarkers; precision medicine; pharmacological interventions; healthy aging; translational geriatric research

(This special issue belongs to the Section Molecular and Translational Medicine)

Stem Cell Therapy and Tissue Engineering

edited by

Nurettin Sahiner

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: stem cells; stem cell therapy; stem cell cancer therapy; hydrogels/cryogels; porous network biomaterials; tissue engineering

(This special issue belongs to the Section Cell Biology and Pathology)

Vitamin D: Latest Scientific Discoveries in Health and Disease

edited by

Mohamed Abouzid

submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open

Keywords: vitamin D; vitamin D metabolites; metabolic pathways; vitamin D receptor; polymorphisms; pathogenesis; vitamin D deficiency

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Type 2 Diabetes: Insulin Regulation and Therapeutic Strategies

edited by

Syed A. A. Rizvi

submission deadline 31 Oct 2025 | Viewed by 80 | Submission Open

Keywords: type 2 diabetes; insulin regulation; glycemic control; insulin resistance; therapeutic strategies; personalized medicine; GLP-1 receptor agonists; SGLT2 inhibitors; novel insulin formulations; non-insulin therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Tumor Microenvironment in Cancer: Basic Science, Artificial Intelligence, and Clinical Research

edited by Rada Amin

submission deadline 31 Oct 2025 | Viewed by 74 | Submission Open

Keywords: tumor microenvironment; cancer progression; malignancies; immunotherapy; therapy resistance; immune evasion

(This special issue belongs to the Section Cancer Biology and Oncology)

Immune Checkpoint Regulation and Signaling Pathways in Cancer

edited by Sreeja C. Sekhar

submission deadline 31 Oct 2025 | Viewed by 74 | Submission Open

Keywords: tumor-immune evasion and interaction; immune check point inhibition; PD-1/PDL-1 pathway; T-cell exhaustion and tumor microenvironment; single-cell profiling; therapeutic resistance; tumor-infiltrating cells; checkpoint inhibitors and immune modulation

(This special issue belongs to the Section Immunology and Immunotherapy)

Dualistic Equilibrium in Neurotransmission and Beyond: Unraveling the Pathophysiology and Unlocking Novel Therapeutic Targets in Neuropsychiatric Disorders—2nd Edition

edited by

Masaru Tanaka

and

Simone Battaglia

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

An Update on Mechanisms and Treatments for Thyroid Cancer in Current Oncology, 2nd Edition

edited by Zhilong Ai

submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open

Keywords: thyroid cancer; mechanisms; treatments; biomarkers; precision medicine; infiltration; metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

The Intricacies of Developmental and Epileptic Encephalopathies: A Journey Towards Innovative Therapies

edited by Muhammad Nauman Arshad and Paul Davies

submission deadline 31 Oct 2025 | Viewed by 69 | Submission Open

Keywords: cognitive; behavioral deficits

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Interaction Between Microbiota and Immunity in Health and Diseases

edited by Giuseppe Merra

submission deadline 31 Oct 2025 | Viewed by 68 | Submission Open

Keywords: microbiota; microbiome; inflammation; immunity; epithelial barrier

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Antipsychotics: 70 Years—2nd Edition

edited by

Giovanni Lentini

and

Serge Mignani

submission deadline 31 Oct 2025 | Viewed by 66 | Submission Open

Keywords: polypharmacology; multi-target drugs; emerging therapeutic targets; repurposing; complementary medicine; psychosis; schizophrenia; bipolar disorder; Alzheimer’ s disease

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biological Role of Oxidative Stress in Inflammatory Processes

edited by

Magdalena Paulina Kasprzak

submission deadline 31 Oct 2025 | Viewed by 66 | Submission Open

Keywords: oxidative stress; redox balance; antioxidants; NRF2; microbiota; bilirubin; Tlr4; inflammation

(This special issue belongs to the Section Cell Biology and Pathology)

New Molecular Insights into the Pathogenesis and Drug Development of Neurodegenerative Diseases: 2nd Edition

edited by Aifang Cheng, Beika Zhu and Fulin Ma

submission deadline 31 Oct 2025 | Viewed by 65 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; molecular mechanisms; high-throughput drug screening; drug repurposing; cellular and animal models; brain organoids; mode of action; pharmacological evaluations; preclinical study

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Fetal Medicine: New Insight and Future Direction

edited by

Carl Weiner

and

Judith Klein-Seetharaman

submission deadline 31 Oct 2025 | Viewed by 63 | Submission Open

Keywords: fetal medicine; spontaneous preterm birth; early-onset pre-eclampsia; fetal hypoxia; poor growth

(This special issue belongs to the Section Cell Biology and Pathology)

Mechanistic Insights into Protein Dynamics: Membrane Interactions, Phase Separation, and Disease-Linked Aggregation

edited by Ramesh Prasad

submission deadline 31 Oct 2025 | Viewed by 62 | Submission Open

Keywords: protein conformational dynamics; membrane-mediated interactions; liquid– liquid phase separation (LLPS); neurodegenerative protein aggregation; structural biology techniques

(This special issue belongs to the Section Cell Biology and Pathology)

Regulation of Bone Homeostasis: Crosstalk Between Osteoblasts and Osteoclasts

edited by

Xiangguo Che

submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open

Keywords: bone homeostasis; bone remodeling; osteoporosis; vascular calcification; osteoblast; osteoclast; signaling pathways; cellular communication; regulatory mechanisms

(This special issue belongs to the Section Cell Biology and Pathology)

Cancer-Associated Thrombosis: From Biomarkers to Diagnostic and Therapeutic Strategies to Optimize Treatment

edited by

Roberta Pancani

and Gualtiero Palareti

submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open

Keywords: cancer-associated thrombosis; venous thrombosis; biomarkers; pulmonary embolism; precision medicine; diagnostic optimization

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodevelopmental Disorders: From Mechanisms to Therapeutic Approaches

edited by Manuel López-Aranda

submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder (ASD); attention-deficit/hyperactivity disorder (ADHD); intellectual disability; schizophrenia; neuroimaging; molecular mechanisms; genetic and epigenetic factors; translational neuroscience; therapeutic interventions

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advanced Research in Anticancer Inhibitors and Targeted Therapy

edited by Changmin Peng and

Hassan Ebrahim

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: histone deacetylases (HDACs); YAP signaling; targeted therapy; oncogenic signaling; biomarker discovery; small-molecule inhibitors; cancer drug resistance; epigenetic therapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Diagnostic Biomarkers and Novel Therapeutics Targets for Fragile X Syndrome, Autism Spectrum Disorders and Genetic Neurodevelopmental Diseases: Advances and Challenges, 2nd Edition

edited by Yolanda De Diego-Otero and Rocio Calvo-Medina

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: fragile X syndrome; autism spectrum disorders; neurodevelopmental disorders; developmental neuroscience; cognitive development

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Latest Advancements in Radiotherapy

edited by

Moshi Geso

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: radiobiology; dosimetry; nanoparticles; FLASH; radiation

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis, Diagnosis and Treatment of Melanoma

edited by Vijayasteltar B. Liju

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: melanoma; metastasis; targeted therapies; immunotherapy; tumor microenvironment; combination therapies; molecular pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss

edited by

Wissam Ghusn

submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); gastro-esophageal reflux disease (GERD); obesity; cardiometabolic comorbidities; type 2 diabetes; hypertension; gut hormones; gastrointestinal function

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Emerging Trends in Cancer: Biomarkers, Therapeutic Strategies and Future Directions

edited by Nedime Serakinci

submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open

Keywords: cancer biomarkers; stem cells; personalized medicine; emerging cancer therapies; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in 3D Bioprinting: From Materials to Functional Tissue Constructs

edited by

Tina Maver

submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open

Keywords: 3D bioprinting; tissue engineering; biofabrication; regenerative medicine; bioprinted skin; organ-on-a-chip; biomaterials; vascularized constructs

(This special issue belongs to the Section Biomedical Engineering and Materials)

Platelets in Human Health and Diseases

edited by Joanna Sikora

submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open

Keywords: platelet; hemostasis; thrombosis; antiplatelet drugs; inflammation; cancer; cardiovascular diseases

(This special issue belongs to the Section Cell Biology and Pathology)

Glioma Therapy: Current Status and Future Prospects

edited by Bernd Kaina

submission deadline 31 Oct 2025 | Viewed by 43 | Submission Open

Keywords: glioblastoma; temozolomide; nitrosoureas; immunotherapy; biologicals; tyrosine kinase inhibitors; senotherapeutics

(This special issue belongs to the Section Cancer Biology and Oncology)

Male Reproductive Medicine: From Basic to Clinical Research

edited by Donghui Huang

submission deadline 31 Oct 2025 | Viewed by 42 | Submission Open

Keywords: male reproductive function; spermatogenesis; hormonal regulation; genetic and epigenetic influences; environmental toxicology; male reproductive health

(This special issue belongs to the Section Molecular and Translational Medicine)

From Multinodular Goiter to Thyroid Cancer—Diagnosis and Treatment

edited by

Beata Wojtczak

submission deadline 31 Oct 2025 | Viewed by 42 | Submission Open

Keywords: multinodular goiter; thyroid cancer; thyroid disorders; thyroid nodules; thyroid gland

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Neutrophils in Immunity and Diseases: 2nd Edition

edited by

Akrivi Chrysanthopoulou

submission deadline 31 Oct 2025 | Viewed by 41 | Submission Open

Keywords: neutrophils; inflammation; neutrophil biology; immunity; NETs

(This special issue belongs to the Section Cell Biology and Pathology)

Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (3rd Edition)

edited by

Francesco Massari

and

Pietro Scicchitano

submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open

Keywords: endothelial function; cardiomyopathies; cardiovascular pharmacology; cardiac therapeutics; noninvasive vascular treatments; molecular cardiac biomarkers; molecular vascular biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Airway Inflammation and Lung Dysfunction

edited by Aruni Jha

submission deadline 31 Oct 2025 | Viewed by 37 | Submission Open

Keywords: airway inflammation; lung dysfunction; acute respiratory distress syndrome (ARDS); chronic obstructive pulmonary disease (COPD); asthma; airway remodeling; therapeutic strategies; inflammation mechanisms

(This special issue belongs to the Section Molecular and Translational Medicine)

Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy 2.0

edited by

Beata Jabłońska

and

Sławomir Mrowiec

submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open

Keywords: inflammatory bowel disease; gastrointestinal tumor; gastrointestinal cancer; acute pancreatitis; chronic pancreatitis; pancreatic cyst; biliary cyst; liver disease; biliary tract disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanomaterials and Nanotechnology in Biomedical Research

edited by

Doǧa Kavaz

submission deadline 31 Oct 2025 | Viewed by 23 | Submission Open

Keywords: nanotechnology; nanomaterials in drug delivery; biosensing; regenerative medicine; theranostics

(This special issue belongs to the Section Nanomedicine and Nanobiology)

“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes

edited by

Lucinda V. Reis

and

Eurico Lima

submission deadline 20 Nov 2025 | Viewed by 43 | Submission Open

Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

The End of the COVID-19 Pandemic—What Is Currently Known and What Could Have Been Useful Four Years Ago? (2nd Edition)

edited by

Monika Zajkowska

and

Monika Gudowska-Sawczuk

submission deadline 30 Nov 2025 | 12 articles | Viewed by 23542 | Submission Open

Keywords: COVID-19; SARS-CoV-2; pandemic; diagnosis; biomarkers; treatment; immunity; inflammation; cytokines; vaccine

(This special issue belongs to the Section Molecular and Translational Medicine)

Dopamine Signaling Pathway in Health and Disease—2nd Edition

edited by

Floriana Volpicelli

Maria Concetta Miniaci

and

Luisa Speranza

submission deadline 30 Nov 2025 | 8 articles | Viewed by 15308 | Submission Open

Keywords: differentiation; disease modeling ; dopamine and drugs; gene expression; human stem cells; neuronal development; reprogramming; signaling pathways; neurodegeneration; neuromodulation

(This special issue belongs to the Section Molecular and Translational Medicine)

Progress in Neurodevelopmental Disorders Research

edited by

Catarina Morais Seabra

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6681 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder; attention deficit hyperactivity disorder

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition

edited by

Ana Maria Dascalu

and

Dragos Serban

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6526 | Submission Open

Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

The Neuropharmacology of Cannabinoids: Developments in Medicine

edited by

Tibor Markus Brunt

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4648 | Submission Open

Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

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