Regenerative Medicine for Bone and Cartilage
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 2
Special Issue Editor
2. Orthopaedics, Medical School, University of Queensland, St. Lucia, QLD 4072, Australia
Interests: articular cartilage; bone marrow lesions; osteochondral allograft; osteochondral autograft; matrix autologous chondrocyte implantation; autologous bone grafting
Special Issue Information
Dear Colleagues,
Bone marrow lesions (BMLs) are associated with injuries to the articular cartilage surface; these radiographic findings can represent progression of intra-articular osteochondral lesions, healing following regenerative procedures or precursors to the development of osteoarthritis in the knee. Radiographically, these lesions demonstrate increased sclerosis and/or cystic lesions on X-ray and Cat Scan (CT) images and a bright signal on T2-weighted and a dark signal on T1-weighted magnetic resonance images (MRIs). These imaging findings have been mislabeled as “bone marrow edema” by clinicians but histologically little evidence of inflammation is demonstrated. Pathologically, fibrofatty or fibrovascular (fibrotic) composition, remodeling and trabecular thinning or thickening can be seen. Again, cystic formation in combination with necrosis, hemorrhaging and finally inflammation is demonstrated as well. Various clinical conditions present radiographically with similar appearances. Traumatic contusions with or without ligamentous damage spontaneous insufficiency fractures (SIFs), osteoarthritis, osteonecrosis, and pain syndromes can demonstrate BMLs. Treatment of these conditions varies based on the etiology and clinical findings as a result. This Special Issue will explore the use of regenerative medicine to treat these various conditions.
Dr. Deryk Jones
Guest Editor
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Keywords
- articular cartilage
- bone marrow lesion
- osteochondral allograft and autograft
- chondrocyte
- trabeculae
- magnetic resonance image
- regeneration
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