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Biomedicines
Special Issues
Microbial Metabolites and Their Impact on Gut Homeostasis
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Microbial Metabolites and Their Impact on Gut Homeostasis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 895

Special Issue Editors

Dr. Federica Laudisi

E-Mail Website
Guest Editor
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
Interests: inflammatory bowel disease; intestinal inflammation; colorectal cancer; intestinal epithelial barrier; microbiota
Special Issues, Collections and Topics in MDPI journals
Dr. Carmine Stolfi

E-Mail Website
Guest Editor
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
Interests: colorectal cancer; immunotherapy; inflammatory bowel diseases; anti-cancer drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A growing body of research pinpoints a significant impact of the gut microbiota on human health and disease due to its ability to influence the intestinal epithelial barrier’s function and the host’s immune response. In particular, the intestinal microbiome, taking advantage of dietary compounds, can produce and release numerous metabolites that play a role in the regulation of host physiology, and some microbial metabolites can even be synthesized by gut microbes. These microbe-related molecules can serve as substrates for metabolic reactions and are crucial in modulating host–microbiota interactions.

In this Special Issue, we will focus on the role of microbial metabolites in gut homeostasis, a fine-tuned balance between the intestinal epithelial barrier, commensals, and host immunity, ensuring the absorption of nutrients and protection against enteric pathogens and xenobiotic substances. We will also discuss these compounds’ potential therapeutic implications in treating intestinal and extra-intestinal disorders.

We invite researchers working on the gut microbiota and the related metabolites to submit original articles or reviews to improve our knowledge of this complex and fascinating field.

Dr. Federica Laudisi
Dr. Carmine Stolfi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal microbiota
  • microbial metabolites
  • gut homeostasis
  • inflammatory response
  • intestinal epithelial barrier
  • immune response
  • diet

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Published Papers (1 paper)

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Research

12 pages, 825 KiB  
Article
Periodic Changes in the Gut Microbiome in Women with the Mixed Type of Irritable Bowel Syndrome
by Aleksandra Kaczka, Aleksandra Błońska, Cezary Chojnacki, Anita Gąsiorowska, Janusz Błasiak, Tomasz Popławski and Jan Chojnacki
Biomedicines 2025, 13(3), 652; https://doi.org/10.3390/biomedicines13030652 - 7 Mar 2025
Viewed by 620
Abstract
Background: The mixed type of irritable bowel syndrome (IBS-M) is characterized by recurrent constipation and diarrhea. The cause of the variability of these symptoms is not sufficiently understood. The aim of this study was to perform metagenomic and metabolic assessment of the gut [...] Read more.
Background: The mixed type of irritable bowel syndrome (IBS-M) is characterized by recurrent constipation and diarrhea. The cause of the variability of these symptoms is not sufficiently understood. The aim of this study was to perform metagenomic and metabolic assessment of the gut microbiome in constipation and diarrheal period of IBS-M. Methods: This study included 30 women, aged 28–47 years old, with the symptoms which aligned with those of IBS-M, according to the Rome IV Criteria. Results: In both periods of the disease, the dysbiosis index (DI), the Shannon diversity index (SDI), the hydrogen–methane and ammonia breath tests, as well as the selected bacterial metabolites (-p-hydroxyphenyl acetic acid (HPA), 3-indoxyl sulfate (Indican, 3-IS)), and hippuric acid (A) in urine, were determined. The dysbiosis index (DI) in the period of constipation was 3.73 ± 0.90 points, and in the diarrheal period it did not change significantly 3.93 ± 0.75 points (p > 0.05). During the diarrheal period, the diversity of bacteria increases from 2.16 ± 0.59 to 2.74 ± 0.50 points on the Shannon dietary index (p < 0.001). The gut microbiome profile also changed, especially during the diarrheal period where an abundance of Bifidobacterium spp. and Lactobacillus spp. decreased significantly. In addition, during this period, the levels of hydrogen and ammonia in breath air increased, while the methane level decreased. The differences also concern the results of urinary metabolites, especially related to hippuric acid and indican. During the diarrheal period, the levels of hydrogen and ammonia ions increased, while the methane level decreased. The differences also concern the results of urinary metabolites, especially related to hippuric acid and indican. Conclusions: In patients with IBS-M, periodic changes in the profile and metabolism of the gut microbiome occur, which coexist with recurrent symptoms such as constipation and diarrhea. Full article
(This article belongs to the Special Issue Microbial Metabolites and Their Impact on Gut Homeostasis)
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