Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 989

Special Issue Editor


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Guest Editor
Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
Interests: cancer–stroma interaction; maternal–fetal interfaces; mechanobiology; tissue engineering; microphysiological systems

Special Issue Information

Dear Colleagues,

This Special Issue seeks to showcase research that merges the fields of engineering and biology through the lens of mechanobiology. We aim to highlight studies that provide insights into critical biological processes and develop innovative bioengineering solutions.

Contributors are encouraged to submit original research articles, comprehensive reviews and case studies that explore the mechanical aspects of biological systems from a molecular to an organ scale. This includes advances in microphysiological systems that mimic the pathophysiological context of cells, innovations in bioengineering that contribute to our understanding of disease pathogenesis and the application of mechanobiology findings to develop therapeutic strategies.

The Special Issue targets an interdisciplinary audience of biologists, bioengineers and medical researchers, aiming to foster a collaborative dialogue that bridges theoretical knowledge with clinical and practical applications. We particularly welcome contributions that push the boundaries of how mechanical forces can influence and dictate biological function and pathology, thus opening new avenues for mechanobiological research in health and disease.

Dr. Wenqiang Du
Guest Editor

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Keywords

  • mechanomedicine
  • mechanobiology
  • microphysiological systems
  • bioengineering
  • forces

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Published Papers (1 paper)

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Research

17 pages, 4553 KiB  
Article
Numerical Simulation of the Effect of Electrical Stimulation on Disuse After Hip Replacement
by Qian Wang, Chuanyong Qu, Xiaohui Li and Yufan Yan
Biomedicines 2025, 13(2), 471; https://doi.org/10.3390/biomedicines13020471 - 14 Feb 2025
Viewed by 607
Abstract
Background: Total hip replacement replaces the femoral head, which cannot heal, with an artificial femoral shaft to ensure the patient’s normal life. However, due to the stress-masking effect of the proximal femur loaded with the artificial femur stem, the implant bears a large [...] Read more.
Background: Total hip replacement replaces the femoral head, which cannot heal, with an artificial femoral shaft to ensure the patient’s normal life. However, due to the stress-masking effect of the proximal femur loaded with the artificial femur stem, the implant bears a large part of the load, resulting in insufficient stress stimulation of the proximal femur and bone waste remodeling. In turn, it is easy to lose bone, resulting in loosening. As a new treatment method, electrical stimulation has been widely used for bone loss, nonunion, and other diseases, and it has achieved good therapeutic effects. Methods: Therefore, in this work, electrical stimulation was introduced for postoperative density assessment, and a new disuse remodeling model was established to simulate density loss after remodeling and the resistance effect of electrical stimulation. The effects of various parameters on density loss in the model are discussed. Results: The simulation results revealed significant stress masking and density loss in the neck of the femur after hip replacement, and electrical stimulation placed in the neck of the femur may resist this density loss to a certain extent. The rate of bone mineral density reduction decreased after the addition of electrical stimulation, indicating that electrical stimulation can have a certain resistance to the density reduction caused by stress shielding, and this result is helpful for the rehabilitation of hip arthroplasty. Full article
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