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Biomedicines
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Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology
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Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1213

Special Issue Editor

Dr. Wenqiang Du

E-Mail Website
Guest Editor
Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
Interests: cancer–stroma interaction; maternal–fetal interfaces; mechanobiology; tissue engineering; microphysiological systems

Special Issue Information

Dear Colleagues,

This Special Issue seeks to showcase research that merges the fields of engineering and biology through the lens of mechanobiology. We aim to highlight studies that provide insights into critical biological processes and develop innovative bioengineering solutions.

Contributors are encouraged to submit original research articles, comprehensive reviews and case studies that explore the mechanical aspects of biological systems from a molecular to an organ scale. This includes advances in microphysiological systems that mimic the pathophysiological context of cells, innovations in bioengineering that contribute to our understanding of disease pathogenesis and the application of mechanobiology findings to develop therapeutic strategies.

The Special Issue targets an interdisciplinary audience of biologists, bioengineers and medical researchers, aiming to foster a collaborative dialogue that bridges theoretical knowledge with clinical and practical applications. We particularly welcome contributions that push the boundaries of how mechanical forces can influence and dictate biological function and pathology, thus opening new avenues for mechanobiological research in health and disease.

Dr. Wenqiang Du
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanomedicine
  • mechanobiology
  • microphysiological systems
  • bioengineering
  • forces

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Published Papers (2 papers)

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Research

21 pages, 4565 KiB  
Article
Experimental Study of Two-Bite Test Parameters for Effective Drug Release from Chewing Gum Using a Novel Bio-Engineered Testbed
by Kazem Alemzadeh and Joseph Alemzadeh
Biomedicines 2025, 13(8), 1811; https://doi.org/10.3390/biomedicines13081811 - 24 Jul 2025
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Abstract
Background: A critical review of the literature demonstrates that masticatory apparatus with an artificial oral environment is of interest in the fields including (i) dental science; (ii) food science; (iii) the pharmaceutical industries for drug release. However, apparatus that closely mimics human [...] Read more.
Background: A critical review of the literature demonstrates that masticatory apparatus with an artificial oral environment is of interest in the fields including (i) dental science; (ii) food science; (iii) the pharmaceutical industries for drug release. However, apparatus that closely mimics human chewing and oral conditions has yet to be realised. This study investigates the vital role of dental morphology and form–function connections using two-bite test parameters for effective drug release from medicated chewing gum (MCG) and compares them to human chewing efficiency with the aid of a humanoid chewing robot and a bionics product lifecycle management (PLM) framework with built-in reverse biomimetics—both developed by the first author. Methods: A novel, bio-engineered two-bite testbed is created for two testing machines with compression and torsion capabilities to conduct two-bite tests for evaluating the mechanical properties of MCGs. Results: Experimental studies are conducted to investigate the relationship between biting force and crushing/shearing and understand chewing efficiency and effective mastication. This is with respect to mechanochemistry and power stroke for disrupting mechanical bonds releasing the active pharmaceutical ingredients (APIs) of MCGs. The manuscript discusses the effect and the critical role that jaw physiology, dental morphology, the Bennett angle of mandible (BA) and the Frankfort-mandibular plane angle (FMA) on two-bite test parameters when FMA = 0, 25 or 29.1 and BA = 0 or 8. Conclusions: The impact on other scientific fields is also explored. Full article
(This article belongs to the Special Issue Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology)
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Graphical abstract

17 pages, 4553 KiB  
Article
Numerical Simulation of the Effect of Electrical Stimulation on Disuse After Hip Replacement
by Qian Wang, Chuanyong Qu, Xiaohui Li and Yufan Yan
Biomedicines 2025, 13(2), 471; https://doi.org/10.3390/biomedicines13020471 - 14 Feb 2025
Viewed by 739
Abstract
Background: Total hip replacement replaces the femoral head, which cannot heal, with an artificial femoral shaft to ensure the patient’s normal life. However, due to the stress-masking effect of the proximal femur loaded with the artificial femur stem, the implant bears a large [...] Read more.
Background: Total hip replacement replaces the femoral head, which cannot heal, with an artificial femoral shaft to ensure the patient’s normal life. However, due to the stress-masking effect of the proximal femur loaded with the artificial femur stem, the implant bears a large part of the load, resulting in insufficient stress stimulation of the proximal femur and bone waste remodeling. In turn, it is easy to lose bone, resulting in loosening. As a new treatment method, electrical stimulation has been widely used for bone loss, nonunion, and other diseases, and it has achieved good therapeutic effects. Methods: Therefore, in this work, electrical stimulation was introduced for postoperative density assessment, and a new disuse remodeling model was established to simulate density loss after remodeling and the resistance effect of electrical stimulation. The effects of various parameters on density loss in the model are discussed. Results: The simulation results revealed significant stress masking and density loss in the neck of the femur after hip replacement, and electrical stimulation placed in the neck of the femur may resist this density loss to a certain extent. The rate of bone mineral density reduction decreased after the addition of electrical stimulation, indicating that electrical stimulation can have a certain resistance to the density reduction caused by stress shielding, and this result is helpful for the rehabilitation of hip arthroplasty. Full article
(This article belongs to the Special Issue Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology)
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