Immunometabolic Determinants of Gut–Liver Axis Health

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 77

Special Issue Editor


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Guest Editor
Molecular Immunonutrition Group, Madrid Institute for Advanced Studies in Food (IMDEA-Food), 28049 Madrid, Spain
Interests: immunonutrition; macrophages; trained immunity; gut-liver axis; microbiota
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Special Issue Information

Dear Colleagues,

The bidirectional relationship between environmental conditions in the intestinal tract and liver function is undoubted and widely accepted. The interaction of stimuli affecting the gut microbiota and intestinal immune system are critical determinants of liver function. The composition of the microbiota seems to be subjected and conditioned to the maturation, orientation, and magnitude of the innate and adaptive immune responses. However, it is the ecometabolic conditions that are presented as key effectors in the function and direction of the immune response(s). These interactions determine the 'entero-hepatic' axis, this being the basis of various influences on the functions of other internal organs. A clear example of this is the impact of the entire hepatic axis on the function of the central nervous system, as well as the lungs and kidneys. From a global point of view, the pathologies associated with imbalances in the functions and immunometabolic conditions of these organs share bases that present their molecular origin in the emerging signaling in the intestinal context. This complex network of interactions in the 'entero-hepatic' axis represents an important challenge for the biomedical sector. Thus, it must face various aspects that are extremely involved in the development of pathologies with an enormous impact on our society. A critical view of this area of research reveals the existence of numerous unanswered questions, as well as the need for a multidisciplinary approach to support the translation of biomedical studies into effective precision medicines in health promotion.

Dr. Jose Moisés Laparra
Guest Editor

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Keywords

  • gut microbiota
  • 'entero-hepatic' axis
  • gut–liver axis
  • immunometabolism

Published Papers

This special issue is now open for submission.
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