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Biomedicines
Special Issues
The Art of ART (Assisted Reproductive Technologies)
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The Art of ART (Assisted Reproductive Technologies)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 132

Special Issue Editor

Dr. Dimitrios Papageorgiou

E-Mail Website
Guest Editor
Department of Gynecology, Athens Naval and Veteran Hospital, 11521 Athens, Greece
Interests: minimally invasive gynecology; gynecology; endometriosis; gynecologic malignancies; HIPEC; obstetrics; high risk pregnancies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The management of infertility has changed because of the development of Assisted Reproductive Technologies (ART). Reproductive medicine is constantly expanding thanks to new advancements in treatments like intrauterine insemination (IUI), intracytoplasmic sperm injection (ICSI), and in vitro fertilization (IVF).

The scientific and clinical significance of ART innovation will be highlighted in this Special Issue, with a focus on improving infertility diagnosis and reproductive outcomes.  The creation of technologies to improve oocyte quality and embryo implantation capacity will be one of the main areas of concentration.  Targeting critical phases of oocyte and embryo physiology, such as chromosomal integrity, fertilization effectiveness, oocyte growth and maturation, and embryo development, is the goal of these technologies.

We are looking for submissions that address preimplantation genetic testing (PGT), mitochondrial replacement therapy (MRT), culture media enhancements, follicle recruitment for better oocyte selection, and the optimization of in vitro fertilization (IVF) techniques.  Researchers and clinicians are encouraged to submit case reports, systematic reviews, meta-analyses, and original research for publication that discuss the most recent advancements in ART, in the pathophysiology of infertility, in preimplantation diagnosis and in the outcomes of IVF applications.

We look forward to receiving high-quality submissions that advance reproductive medicine and ART.

Dr. Dimitrios Papageorgiou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assisted reproductive technologies
  • infertility diagnosis
  • intrauterine insemination (IUI)
  • intracytoplasmic sperm injection (ICSI)
  • in vitro fertilization (IVF)
  • embryo implantation
  • oocyte quality
  • preimplantation genetic testing
  • mitochondrial replacement therapy
  • follicular recruitment
  • reproductive medicine

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Published Papers (1 paper)

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Research

11 pages, 358 KiB  
Article
Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters
by Mahira Ismayilova, Aytakin Hasanova and Andrei Semikhodskii
Biomedicines 2025, 13(5), 1191; https://doi.org/10.3390/biomedicines13051191 (registering DOI) - 13 May 2025
Abstract
Background/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious [...] Read more.
Background/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious concern in programmes of assisted reproductive technologies. Recently, the introduction of preimplantation genetic testing for aneuploidies (PGT-A) has increased the pregnancy rate and live births. We investigated the effect of PGT-A on the success of IVF treatment in couples with the male factor of infertility. Methods: Two experimental groups and one control group were studied: Group A (110 couples)—male partners with abnormal semen parameters, with PGT-A; Group B (110 couples)—male partners with abnormal semen parameters, without PGT-A; and Group C (105 couples)—control, male partners with normal spermograms, with PGT-A. A Day 3 blastomere biopsy was followed by FISH-based PGT-A. A total of 880 embryos from Group A and 890 embryos from Group C was analysed. Results: In patients with abnormal semen parameters, embryonic aneuploidy was twice as common compared to the control (13.6% vs. 5.8%, p < 0.001). Group B had the lowest clinical pregnancy rate (28.2%), with two out of three pregnancies ending in a miscarriage. Only 10% of IVF cycles in this group resulted in live birth compared with 35.5% for Group A and 49.5% for Group C. Conclusions: Our data demonstrate that PGT-A screening as part of IVF treatment drastically increases the clinical pregnancy rate and chances of live birth in couples where male partners have semen abnormality. Full article
(This article belongs to the Special Issue The Art of ART (Assisted Reproductive Technologies))
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