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Biomedicines
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The Art of ART (Assisted Reproductive Technologies)
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The Art of ART (Assisted Reproductive Technologies)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 3425

Special Issue Editor

Dr. Dimitrios Papageorgiou

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Guest Editor
Department of Gynecology, Athens Naval and Veterans Hospital, 11521 Athens, Greece
Interests: minimal invasive gynecological surgery; gynecologic oncology; endoscopic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The management of infertility has changed because of the development of Assisted Reproductive Technologies (ART). Reproductive medicine is constantly expanding thanks to new advancements in treatments like intrauterine insemination (IUI), intracytoplasmic sperm injection (ICSI), and in vitro fertilization (IVF).

The scientific and clinical significance of ART innovation will be highlighted in this Special Issue, with a focus on improving infertility diagnosis and reproductive outcomes.  The creation of technologies to improve oocyte quality and embryo implantation capacity will be one of the main areas of concentration.  Targeting critical phases of oocyte and embryo physiology, such as chromosomal integrity, fertilization effectiveness, oocyte growth and maturation, and embryo development, is the goal of these technologies.

We are looking for submissions that address preimplantation genetic testing (PGT), mitochondrial replacement therapy (MRT), culture media enhancements, follicle recruitment for better oocyte selection, and the optimization of in vitro fertilization (IVF) techniques.  Researchers and clinicians are encouraged to submit case reports, systematic reviews, meta-analyses, and original research for publication that discuss the most recent advancements in ART, in the pathophysiology of infertility, in preimplantation diagnosis and in the outcomes of IVF applications.

We look forward to receiving high-quality submissions that advance reproductive medicine and ART.

Dr. Dimitrios Papageorgiou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assisted reproductive technologies
  • infertility diagnosis
  • intrauterine insemination (IUI)
  • intracytoplasmic sperm injection (ICSI)
  • in vitro fertilization (IVF)
  • embryo implantation
  • oocyte quality
  • preimplantation genetic testing
  • mitochondrial replacement therapy
  • follicular recruitment
  • reproductive medicine

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Published Papers (4 papers)

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Research

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12 pages, 269 KB  
Article
Chlamydia trachomatis-Specific Antibodies and In Vitro Fertilization Outcome
by Natasa Djordjevic, Ana Todorovic, Predrag Sazdanovic, Maja Sazdanovic, Marija Sorak, Aleksandra Gavrilovic, Aida Parandilovic, Eliana Garalejic, Marija Vujovic, Sanja Matic, Suzana Popovic and Dejan Baskic
Biomedicines 2025, 13(8), 2032; https://doi.org/10.3390/biomedicines13082032 - 20 Aug 2025
Viewed by 800
Abstract
Objectives: Chlamydia trachomatis (CT) infection affects female fertility. The purpose of our study was to assess the association between serological and follicular fluid markers of CT infection and in vitro fertilization (IVF) success. Methods: This prospective multicenter cohort study included female [...] Read more.
Objectives: Chlamydia trachomatis (CT) infection affects female fertility. The purpose of our study was to assess the association between serological and follicular fluid markers of CT infection and in vitro fertilization (IVF) success. Methods: This prospective multicenter cohort study included female patients undergoing an IVF procedure in Serbia. The IVF procedure was performed according to the standard protocol. Serum and follicular fluid samples were collected during IVF, and anti-major outer membrane protein (anti-MOMP) IgG and IgA were determined by the Enzyme-Linked Immunosorbent Assay (ELISA) test. Results: A significantly higher embryo implantation rate was detected among patients negative for antibodies in follicular fluid (OR (95% CI): 5.254 (1.055; 26.152)). There was a trend toward increased risk of IVF failure in patients positive for either IgG or IgA in follicular fluid, or positive for IgG in serum. Older age was associated with lower odds for successful implantation (OR (95% CI): 0.888 (0.820; 0.962)), biochemical pregnancy (OR (95% CI): 0.890 (0.817; 0.969)), and live birth (OR (95% CI): 0.906 (0.833; 0.985)). Conclusions: Our results suggest that the presence of chlamydial anti-MOMP IgG and IgA in the serum and follicular fluid of infertile women could be indicative of lower IVF success rate, and that advanced maternal age is associated with higher risk of IVF failure. Full article
(This article belongs to the Special Issue The Art of ART (Assisted Reproductive Technologies))
11 pages, 1218 KB  
Article
Predictive Ability of an Objective and Time-Saving Blastocyst Scoring Model on Live Birth
by Bing-Xin Ma, Feng Zhou, Guang-Nian Zhao, Lei Jin and Bo Huang
Biomedicines 2025, 13(7), 1734; https://doi.org/10.3390/biomedicines13071734 - 15 Jul 2025
Viewed by 606
Abstract
Objectives: With the development of artificial intelligence technology in medicine, an intelligent deep learning-based embryo scoring system (iDAScore) has been developed on full-time lapse sequences of embryos. It automatically ranks embryos according to the likelihood of achieving a fetal heartbeat with no manual [...] Read more.
Objectives: With the development of artificial intelligence technology in medicine, an intelligent deep learning-based embryo scoring system (iDAScore) has been developed on full-time lapse sequences of embryos. It automatically ranks embryos according to the likelihood of achieving a fetal heartbeat with no manual input from embryologists. To ensure its performance, external validation studies should be performed at multiple clinics. Methods: A total of 6291 single vitrified–thawed blastocyst transfer cycles from 2018 to 2021 at the Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology were retrospectively analyzed by the iDAScore model. Patients with two or more blastocysts transferred and blastocysts that were not cultured in a time-lapse incubator were excluded. Blastocysts were divided into four comparably sized groups by first sorting their iDAScore values in ascending order and then compared with the clinical, perinatal, and neonatal outcomes. Results: Our results showed that clinical pregnancy, miscarriage, and live birth significantly correlated with iDAScore (p < 0.001). For perinatal and neonatal outcomes, no significant difference was shown in four iDAScore groups, except sex ratio. Uni- and multivariable logistic regressions showed that iDAScore was significantly positively correlated with live birth rate (p < 0.05). Conclusions: In conclusion, the objective ranking can prioritize embryos reliably and rapidly for transfer, which could allow embryologists more time for processes requiring hands-on procedures. Full article
(This article belongs to the Special Issue The Art of ART (Assisted Reproductive Technologies))
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11 pages, 233 KB  
Article
Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters
by Mahira Ismayilova, Aytakin Hasanova and Andrei Semikhodskii
Biomedicines 2025, 13(5), 1191; https://doi.org/10.3390/biomedicines13051191 - 13 May 2025
Viewed by 621
Abstract
Background/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious [...] Read more.
Background/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious concern in programmes of assisted reproductive technologies. Recently, the introduction of preimplantation genetic testing for aneuploidies (PGT-A) has increased the pregnancy rate and live births. We investigated the effect of PGT-A on the success of IVF treatment in couples with the male factor of infertility. Methods: Two experimental groups and one control group were studied: Group A (110 couples)—male partners with abnormal semen parameters, with PGT-A; Group B (110 couples)—male partners with abnormal semen parameters, without PGT-A; and Group C (105 couples)—control, male partners with normal spermograms, with PGT-A. A Day 3 blastomere biopsy was followed by FISH-based PGT-A. A total of 880 embryos from Group A and 890 embryos from Group C was analysed. Results: In patients with abnormal semen parameters, embryonic aneuploidy was twice as common compared to the control (13.6% vs. 5.8%, p < 0.001). Group B had the lowest clinical pregnancy rate (28.2%), with two out of three pregnancies ending in a miscarriage. Only 10% of IVF cycles in this group resulted in live birth compared with 35.5% for Group A and 49.5% for Group C. Conclusions: Our data demonstrate that PGT-A screening as part of IVF treatment drastically increases the clinical pregnancy rate and chances of live birth in couples where male partners have semen abnormality. Full article
(This article belongs to the Special Issue The Art of ART (Assisted Reproductive Technologies))

Review

Jump to: Research

13 pages, 235 KB  
Review
Impact of the Female Genital Microbiota on Outcomes of Assisted Reproductive Techniques
by Zacharias Fasoulakis, Dimitrios Papageorgiou, Athanasios Papanikolaou, Marianna Chatziioannou, Ioakeim Sapantzoglou, Afroditi Pegkou, George Daskalakis and Panos Antsaklis
Biomedicines 2025, 13(6), 1332; https://doi.org/10.3390/biomedicines13061332 - 29 May 2025
Viewed by 1088
Abstract
The female genital microbiota plays a critical role in reproductive health and has recently emerged as a key factor influencing the outcomes of Assisted Reproductive Techniques (ARTs). Beyond traditional concerns about vaginal dysbiosis and infections such as bacterial vaginosis or mycoses, recent evidence [...] Read more.
The female genital microbiota plays a critical role in reproductive health and has recently emerged as a key factor influencing the outcomes of Assisted Reproductive Techniques (ARTs). Beyond traditional concerns about vaginal dysbiosis and infections such as bacterial vaginosis or mycoses, recent evidence highlights the broader impact of genital microbial communities, including the vaginal, cervical, and endometrial niches, on ART success rates. New findings suggest that specific bacterial profiles, as well as shifts in the virome and mycobiome, can significantly affect implantation and pregnancy outcomes. Non-invasive biomarkers such as menstrual blood have also been proposed for assessing endometrial receptivity. Furthermore, growing attention has been directed towards methodological challenges such as contamination risks during microbiota sampling which may influence study reliability. This review synthesizes the latest data on the relationship between the female genital microbiota and ART outcomes, with a focus on standardized microbiological analysis techniques and specific patient populations such as those experiencing recurrent implantation to optimize ART success based on microbiota profiling. Full article
(This article belongs to the Special Issue The Art of ART (Assisted Reproductive Technologies))
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