Synaptic Function and Modulation in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 475

Special Issue Editor


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Guest Editor
Center for Neural Engineering & Institute for Technology and Medical Systems Innovation, Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering & Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA
Interests: hierarchical and temporal multiscale modeling of the nervous system; synaptic transmission; learning and memory; cognition in health and disease; therapeutics development; neuromodulation

Special Issue Information

Dear Colleagues,

Synaptic function and modulation are critical for proper nervous system function having been implicated in a myriad of processes ranging from basic neural communication to sophisticated behaviors and complex cognitive functions. Disruptions in synaptic mechanisms underlie a wide range of neurological and psychiatric disorders, highlighting it as a research area of the utmost importance to improve our understanding of these diseases and enable the development of more efficacious therapeutic strategies.

This Special Issue aims to gather recent developments in our understanding of synaptic function and modulation, emphasizing its roles in health and disease.

We encourage our colleagues to submit manuscripts on, but not limited to, the following topics: synaptic plasticity, neurotransmitter release, receptor dynamics, aging, and the impact of genetic and environmental factors on synaptic health. Computational studies are also welcome. By contributing to this Special Issue, authors will be able to share their research with a wide audience and thus foster collaboration and innovation in the field, thereby advancing our cumulative knowledge about this important topic.

Dr. Jean-Marie C. Bouteiller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synaptic function
  • synaptic plasticity
  • neurotransmitter release
  • receptor dynamics

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Published Papers (1 paper)

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Review

22 pages, 2308 KiB  
Review
Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders
by Ángel R. Rábago-Monzón, Juan F. Osuna-Ramos, David A. Armienta-Rojas, Josué Camberos-Barraza, Alejandro Camacho-Zamora, Javier A. Magaña-Gómez and Alberto K. De la Herrán-Arita
Biomedicines 2025, 13(5), 1121; https://doi.org/10.3390/biomedicines13051121 - 6 May 2025
Viewed by 119
Abstract
Stress and sleep share a reciprocal relationship, where chronic stress often leads to sleep disturbances that worsen neurodegenerative and psychiatric conditions. Non-neuronal cells, particularly astrocytes and microglia, play critical roles in the brain’s response to stress and the regulation of sleep. Astrocytes influence [...] Read more.
Stress and sleep share a reciprocal relationship, where chronic stress often leads to sleep disturbances that worsen neurodegenerative and psychiatric conditions. Non-neuronal cells, particularly astrocytes and microglia, play critical roles in the brain’s response to stress and the regulation of sleep. Astrocytes influence sleep architecture by regulating adenosine signaling and glymphatic clearance, both of which can be disrupted by chronic stress, leading to reduced restorative sleep. Microglia, activated under stress conditions, drive neuroinflammatory processes that further impair sleep and exacerbate brain dysfunction. Additionally, the gut–brain axis mediates interactions between stress, sleep, and inflammation, with microbial metabolites influencing neural pathways. Many of these effects converge on the disruption of synaptic processes, such as neurotransmitter balance, synaptic plasticity, and pruning, which in turn contribute to the pathophysiology of neurodegenerative and psychiatric disorders. This review explores how these cellular and systemic mechanisms contribute to stress-induced sleep disturbances and their implications for neurodegenerative and psychiatric disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells and the gut–brain axis. Full article
(This article belongs to the Special Issue Synaptic Function and Modulation in Health and Disease)
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