Molecular Regulation of Spermatozoa—Second Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 674
Special Issue Editor
Interests: reproduction; female fertility preservation; male fertility preservation; female infertility; male infertility; oocyte; sperm; embryo; ovarian tissue; spermatogonial stem cell; testicular tissue; reproductive cells and tissues culture; reproductive cells and tissues cryopreservation; apoptosis; oxidative stress; antioxidant therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infertility is a common problem affecting many couples worldwide. In approximately 50% of cases, the male factor is the primary or contributing cause. In most infertile cases, adequate numbers of spermatozoa are produced, and in fact, these numbers are sufficient to induce pregnancy; however, the biological functions such as capacitation, hyperactivation, acrosome reaction, and fertilizing ability of those spermatozoa have been compromised and are considered the most frequent cause of human infertility. A dynamic interplay between spermatozoa and a constantly changing environment is necessary to activate the underlying molecular events and signaling pathways that regulate sperm functions. Various signaling molecules, such as hormones, immune regulatory molecules, neurotransmitters, ions, proteins, growth factors, and free radicals, regulate sperm functions, mainly through post-translational modifications of proteins. Therefore, the deregulation of those interactions can be behind male factor infertility.
For this Special Issue of ”Biomedicines”, we invite you to contribute either an original research article or a review article on the topic “Molecular Regulation of Spermatozoa.” The scope includes in vitro and in vivo research on molecular mechanisms and signaling pathways that regulate spermatozoa function in physiological conditions and under special conditions, such as those causing male infertility or subfertility. Additionally, any paper related to the redox regulation role in sperm function is welcome.
Dr. Atefeh Najafi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- spermatogenesis
- spermiogenesis
- sperm
- capacitation
- acrosome reaction
- hyperactivation
- fertilization
- male infertility
- antioxidants
- redox regulation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
Related Special Issue
- Molecular Regulation of Spermatozoa in Biomedicines (10 articles)
