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Biomedicines
Special Issues
Epigenetics and Metabolic Disorders
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Epigenetics and Metabolic Disorders

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 3658

Special Issue Editor

Dr. Patrik Krumpolec

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Guest Editor
Medirex Group Academy, 949 05 Nitra, Slovakia
Interests: metabolic diseases; inflammatory bowel diseases; genomics; epigenetics

Special Issue Information

Dear Colleagues,

Metabolic diseases represent a wide spectrum of disorders arising from disruptions in the body's metabolic processes. The constantly increasing incidence and prevalence of metabolic disorders make this group of diseases not only an epidemiological issue but also an economic and societal problem.

One of the causes of metabolic diseases is epigenetic changes in the regulation of genes that control metabolic processes. Understanding epigenetic changes in the context of the development of metabolic diseases has the potential to influence processes related to the onset and progression of these diseases and may lead to new strategies in prevention and treatment.

This Special Issue welcomes original research and review articles dedicated to epigenetic processes underlying the onset and development of metabolic diseases. We encourage authors to contribute to this Special Issue with works related to (but not limited to) the following:

  • Prenatal epigenetic changes related to metabolic diseases;
  • Heredity and epigenetic changes underlying metabolic diseases;
  • The role of epigenetics in relationship of environmental factors and metabolic diseases;
  • Therapeutic interventions targeting abnormal epigenetic markers associated with metabolic diseases.

Dr. Patrik Krumpolec
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic diseases
  • epigenetics
  • DNA methylation
  • histone modification
  • non-coding RNA (ncRNA)-mediated gene regulation
  • heredity
  • environmental factors

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

33 pages, 2598 KiB  
Review
Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs
by Nikolaos Theodorakis and Maria Nikolaou
Biomedicines 2025, 13(1), 135; https://doi.org/10.3390/biomedicines13010135 - 8 Jan 2025
Cited by 10 | Viewed by 3206
Abstract
Cardiovascular–Kidney–Metabolic syndrome, introduced by the American Heart Association in 2023, represents a complex and interconnected spectrum of diseases driven by shared pathophysiological mechanisms. However, this framework notably excludes the liver—an organ fundamental to metabolic regulation. Building on this concept, Cardiovascular–Renal–Hepatic–Metabolic (CRHM) syndrome incorporates [...] Read more.
Cardiovascular–Kidney–Metabolic syndrome, introduced by the American Heart Association in 2023, represents a complex and interconnected spectrum of diseases driven by shared pathophysiological mechanisms. However, this framework notably excludes the liver—an organ fundamental to metabolic regulation. Building on this concept, Cardiovascular–Renal–Hepatic–Metabolic (CRHM) syndrome incorporates the liver’s pivotal role in this interconnected disease spectrum, particularly through its involvement via metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the increasing prevalence of CRHM syndrome, unified management strategies remain insufficiently explored. This review addresses the following critical question: How can novel anti-diabetic agents, including sodium–glucose cotransporter-2 inhibitors (SGLT2is), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and dual gastric inhibitory polypeptide (GIP)/GLP-1RA, offer an integrated approach to managing CRHM syndrome beyond the boundaries of traditional specialties? By synthesizing evidence from landmark clinical trials, we highlight the paradigm-shifting potential of these therapies. SGLT2is, such as dapagliflozin and empagliflozin, have emerged as cornerstone guideline-directed treatments for heart failure (HF) and chronic kidney disease (CKD), providing benefits that extend beyond glycemic control and are independent of diabetes status. GLP-1RAs, e.g., semaglutide, have transformed obesity management by enabling weight reductions exceeding 15% and improving outcomes in atherosclerotic cardiovascular disease (ASCVD), diabetic CKD, HF, and MASLD. Additionally, tirzepatide, a dual GIP/GLP-1RA, enables unprecedented weight loss (>20%), reduces diabetes risk by over 90%, and improves outcomes in HF with preserved ejection fraction (HFpEF), MASLD, and obstructive sleep apnea. By moving beyond the traditional organ-specific approach, we propose a unified framework that integrates these agents into holistic management strategies for CRHM syndrome. This paradigm shift moves away from fragmented, organ-centric management toward a more unified approach, fostering collaboration across specialties and marking progress in precision cardiometabolic medicine. Full article
(This article belongs to the Special Issue Epigenetics and Metabolic Disorders)
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