Advancements in Neuroscience: A Special Issue in Honour of Ramón Y Cajal

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1231

Special Issue Editor

Special Issue Information

Dear Colleagues,

This year marks the 90th anniversary of Ramón y Cajal’s passing. We wish to honour the father of neuroscience with this Special Issue.

Perfectioning Golgi’s staining, Cajal precisely depicted the architecture of neuronal connections, combining his talent for drawing and his devotion to histology. After sharing the Nobel Prize with Camillo Golgi in 1906, Cajal shed light on the contiguous nature of neurons, which he called “the mysterious butterflies of the soul”. He succeeded in tracing, for the first time, the propagation of the nerve impulse through dynamic polarization, advancing brain function research. Beyond his invaluable scientific contributions, which made him a pioneer of modern neuroscience, Cajal merits to be remembered for his fervent enthusiasm, restless work and unconditioned devotion to research. He provided us with powerful tools to explore neuronal connections, inspiring further research.

In order to celebrate Cajal, we invite scholars to contribute original research articles,  reviews and perspectives related to neurobiology achievements, but also to innovative laboratory techniques, fundamental and translational research, therapeutic targets, and strategies for understanding the complexities of healthy and damaged nervous systems.

Dr. Maria A. Bonifacio
Guest Editor

Manuscript Submission Information

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Keywords

  • neurobiology
  • neuroscience
  • histology
  • imaging
  • nervous system
  • brain
  • neurodegenerative diseases
  • neurodevelopmental disorders
  • molecular biology
  • big data mining

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Published Papers (1 paper)

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Research

15 pages, 6366 KiB  
Article
Adaptive and Compensatory Neural Signatures in Fibromyalgia: An Analysis of Resting-State and Stimulus-Evoked EEG Oscillations
by Lucas Camargo, Kevin Pacheco-Barrios, Lucas M. Marques, Wolnei Caumo and Felipe Fregni
Biomedicines 2024, 12(7), 1428; https://doi.org/10.3390/biomedicines12071428 - 27 Jun 2024
Cited by 1 | Viewed by 744
Abstract
This study aimed to investigate clinical and physiological predictors of brain oscillatory activity in patients with fibromyalgia (FM), assessing resting-state power, event-related desynchronization (ERD), and event-related synchronization (ERS) during tasks. We performed a cross-sectional analysis, including clinical and neurophysiological data from 78 subjects [...] Read more.
This study aimed to investigate clinical and physiological predictors of brain oscillatory activity in patients with fibromyalgia (FM), assessing resting-state power, event-related desynchronization (ERD), and event-related synchronization (ERS) during tasks. We performed a cross-sectional analysis, including clinical and neurophysiological data from 78 subjects with FM. Multivariate regression models were built to explore predictors of electroencephalography bands. Our findings show a negative correlation between beta oscillations and pain intensity; fibromyalgia duration is positively associated with increased oscillatory power at low frequencies and in the beta band; ERS oscillations in the theta and alpha bands seem to be correlated with better symptoms of FM; fatigue has a signature in the alpha band—a positive relationship in resting-state and a negative relationship in ERS oscillations. Specific neural signatures lead to potential clusters of neural adaptation, in which beta oscillatory activity in the resting state represents a more adaptive activity when pain levels are low and stimulus-evoked oscillations at lower frequencies are likely brain compensatory mechanisms. These neurophysiological changes may help to understand the impact of long-term chronic pain in the central nervous system and the descending inhibitory system in fibromyalgia subjects. Full article
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