Cutting-Edge Research on Cardiovascular Nuclear Medicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Special Issue “Cutting-Edge Research on Cardiovascular Nuclear Medicine” is inspired by the breakthrough in the domain of transthyretin cardiac amyloidosis during the last decade in terms of early detection and innovative treatment advances. Transthyretin cardiac amyloidosis may be acquired (wild-type) or hereditary (mutant) and is triggered by extracellular deposition of insoluble amyloid fibrils in the myocardial tissue. The differential diagnosis of this progressive infiltrative cardiomyopathy mainly concerns light-chain amyloidosis. the most frequent type of cardiac amyloidosis. Interestingly, both transthyretin and light-chain cardiac amyloidosis mainly affect males. Tissue biopsy and, in selected cases, mass spectrometry remain the gold standard for amyloid fibril typing. The scope of this recruitment encompasses the pathophysiological mechanisms and diagnostic caveats, involving laboratory biomarkers, associated cardiac and extracardiac clinical manifestations, electrocardiographic, echocardiographic, magnetic resonance imaging, and especially nuclear medicine modalities, as well as the novel targeted therapeutic agents. Clarification of the underlying molecular pathogenetic traces coupled with catalytic nuclear imaging tools gradually further reinforces the diagnostic algorithm and guides therapeutic approaches of transthyretin cardiac amyloidosis. Hence, this Special Issue welcomes original articles and reviews by researchers and clinicians in order to share their expertise and insights focusing on traditional and novel nuclear medicine methods (single-photon emission computed tomography (SPECT), positron emission tomography (PET), and/or hybrid systems), including artificial intelligence tools, for the early identification, precise characterization, prognosis, monitoring, and evaluation of response to treatment in cases of transthyretin cardiac amyloidosis. We hope that the contributions to this Special Issue shall enrich the scientific background and clinical practice in the field of cardiac amyloidosis.
Dr. Pipitsa N. Valsamaki
Guest Editor
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Keywords
- transthyretin cardiac amyloidosis
- molecular mechanisms
- nuclear medicine imaging (SPECT, SPECT/CT, PET/CT)
- treatment advancements
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