The Role of Cytokines in Health and Disease: 3rd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 282

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue predominantly covers the usefulness of the determination of cytokines in healthy patients and patients with civilization diseases, with a particular emphasis on neurodegenerative and neoplastic diseases. Despite being non-contagious, civilization diseases are often referred to as the epidemics of the 21st century because they spread globally and lead to over 80% of premature deaths. For many years, it has been observed that society is progressively ageing, which results in an increase in the number of elderly people who are most at risk of developing degenerative diseases of the central nervous system, as well as cancer. As part of this Special Issue, we are looking for new indicators allowing for early detection (even in potentially healthy patients, years before the first symptoms of the emerging disease), and thus a better prognosis of the survival of patients with selected civilization diseases. It is assumed that the introduction of the concentrations of the analyzed proteins to the diagnosis of patients with civilization diseases may facilitate the diagnosis and differentiation of these diseases, and thus enable the early initiation of treatment.

This Special Issue aims to comprehensively study the role of cytokines in health and in various diseases (mainly, but not only, the diseases of civilization, such as cancers or neurodegenerative diseases). Moreover, the aim of this Special Issue is also to understand the involvement of different cytokine groups in diagnosis and/or therapy and to investigate the new potential therapies targeting cytokines. In this Special Issue, original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  • Cytokines as prognostic factors of different diseases;
  • Cytokines as novel tumor markers in malignant tumors;
  • Cytokines in neurodegeneration;
  • Cytokines in neuroinflammation;
  • Cytokines in COVID-19;
  • Potential novel role of cytokines in health and disease.

I look forward to receiving your contributions.

Dr. Monika Zajkowska
Guest Editor

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Keywords

  • cytokine
  • chemokine
  • neurodegenerative disease
  • cancer
  • inflammatory mediator
  • diagnosis
  • biomarker

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30 pages, 3316 KiB  
Systematic Review
Preclinical Evidence of Curcuma longa Linn. as a Functional Food in the Management of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Rodent Studies
by Samuel Abiodun Kehinde, Zahid Naeem Qaisrani, Rinrada Pattanayaiying, Wai Phyo Lin, Bo Bo Lay, Khin Yadanar Phyo, Myat Mon San, Nurulhusna Awaeloh, Sasithon Aunsorn, Ran Kitkangplu and Sasitorn Chusri
Biomedicines 2025, 13(8), 1911; https://doi.org/10.3390/biomedicines13081911 - 5 Aug 2025
Abstract
Background/Objectives: Metabolic syndrome (MetS) is a multifactorial condition characterized by abdominal obesity, dyslipidemia, insulin resistance, hypertension, and chronic inflammation. As its global prevalence rises, there is increasing interest in natural, multi-targeted approaches to manage MetS. Curcuma longa Linn. (turmeric), especially its active [...] Read more.
Background/Objectives: Metabolic syndrome (MetS) is a multifactorial condition characterized by abdominal obesity, dyslipidemia, insulin resistance, hypertension, and chronic inflammation. As its global prevalence rises, there is increasing interest in natural, multi-targeted approaches to manage MetS. Curcuma longa Linn. (turmeric), especially its active compound curcumin, has shown therapeutic promise in preclinical studies. This systematic review and meta-analysis evaluated the effects of Curcuma longa and its derivatives on MetS-related outcomes in rodent models. Methods: A comprehensive search was conducted across six databases (PubMed, Scopus, AMED, LILACS, MDPI, and Google Scholar), yielding 47 eligible in vivo studies. Data were extracted on key metabolic, inflammatory, and oxidative stress markers and analyzed using random-effects models. Results were presented as mean differences (MD) with 95% confidence intervals (CI). Results: Meta-analysis showed that curcumin significantly reduced body weight (rats: MD = −42.10; mice: MD = −2.91), blood glucose (rats: MD = −55.59; mice: MD = −28.69), triglycerides (rats: MD = −70.17; mice: MD = −24.57), total cholesterol (rats: MD = −35.77; mice: MD = −52.61), and LDL cholesterol (rats: MD = −69.34; mice: MD = −42.93). HDL cholesterol increased significantly in rats but not in mice. Inflammatory cytokines were markedly reduced, while oxidative stress improved via decreased malondialdehyde (MDA) and elevated superoxide dismutase (SOD) and catalase (CAT) levels. Heterogeneity was moderate to high, primarily due to variations in curcumin dosage (ranging from 10 to 500 mg/kg) and treatment duration (2 to 16 weeks) across studies. Conclusions: This preclinical evidence supports Curcuma longa as a promising functional food component for preventing and managing MetS. Its multi-faceted effects warrant further clinical studies to validate its translational potential. Full article
(This article belongs to the Special Issue The Role of Cytokines in Health and Disease: 3rd Edition)
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