The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 2712
Special Issue Editor
Interests: cancer; synthesis of antitumor organic compounds; synthesis of fluorescent probes
Special Issue Information
Dear Colleagues,
Natural killer (NK) cells play a pivotal role in immune surveillance and the elimination of tumor cells. Through a set of activating and inhibitory receptors, NK cells recognize and destroy malignant cells; however, tumors have developed evasion mechanisms with which to escape NK-cell-mediated destruction, posing a significant challenge in the field of immunotherapy. This Special Issue explores the mechanisms of NK cell action in the cancer context, the strategies tumors employ to evade NK cell activity, and emerging NK-cell-based therapies, such as CAR-NK cells and combination therapies. Finally, recent clinical trials and future challenges in the clinical implementation of these therapies will be discussed.
Dr. Maria Eugenia Garcia Rubino
Guest Editor
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Keywords
- NK cells
- cancer immunotherapy
- tumor evasion
- cytotoxicity
- CAR-NK
- cytokines
- IL-2
- immunotherapy
- tumor microenvironment
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