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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Research on Colorectal Cancers

edited by

Wangxiong Hu

submission deadline 31 Dec 2025 | Viewed by 29 | Submission Open

Keywords: high microsatellite instability; epigenetic age acceleration; spatial omics and single-cell sequencing; cold tumors and immunotherapy; driver gene; DNA replication repair; liquid biopsy; ctDNA

(This special issue belongs to the Section Cancer Biology and Oncology)

Animal Models for the Study of Cardiovascular Physiology—Second Edition

edited by Sandra Lia Amaral

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: hypertension; stroke; myocardium infarction; arterial stiffness; supravalvular aortic stenosis; cardiac remodeling; capillary angiogenesis; exercise training; vascular diseases; non-pharmacological treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Pathomechanisms of Disturbances Underlying Chronic Disorders—Third Edition

edited by

Dorota Formanowicz

submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open

Keywords: chronic disorders; atherosclerosis; inflammation; oxidative stress; lipoproteins; endothelial dysfunction; biomarkers; pathomechanisms

(This special issue belongs to the Section Immunology and Immunotherapy)

Novel Drug Delivery Systems: Design, Evaluation and Application: 2nd Edition

edited by

Yongtai Zhang

submission deadline 31 Dec 2025 | Viewed by 20 | Submission Open

Keywords: pharmaceutics; drug delivery systems; nanoparticles; nanomedicine; biomolecules; hydrogels; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Pathogenesis and Treatment of Infectious Diseases

edited by Francesca Gioia

submission deadline 31 Dec 2025 | Viewed by 20 | Submission Open

Keywords: antimicrobial resistance; phage therapy; host– pathogen interactions; molecular diagnostics; immunotherapy

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Pathogenesis and Therapeutic Intervention of Alzheimer's Disease

edited by Chanchal Sharma

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: dementia; Alzheimer’ s disease; neuroinflammation; microglia; gene therapy; stem cells; blood– brain barrier; oxidative stress; gut-microbiome; diet; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Signaling of Protein Kinases in Development and Disease (2nd Edition)

edited by

John Zheng Fu

submission deadline 31 Dec 2025 | Viewed by 8 | Submission Open

Keywords: kinase; phosphorylation; signaling; mutation; mechanism; development; inhibitor; disease

(This special issue belongs to the Section Cell Biology and Pathology)

Inflammation in Neurogenerative Diseases: Mechanisms and Therapeutic Frontiers

edited by

Shao-Bin Wang

submission deadline 1 Jan 2026 | Viewed by 47 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; biomarkers mitochondria dysfunction; microglia; immune response; therapeutic development; gene therapy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nanoparticles for Glioblastoma Therapy

edited by Shambhavi Pandey and

Benjamí Oller-Salvia

submission deadline 20 Jan 2026 | Viewed by 27 | Submission Open

Keywords: nanoparticles; blood& ndash; brain barrier; gene delivery; glioblastoma; cancer stem cells; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)

edited by

Gvantsa Kharaishvili

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1554 | Submission Open

Keywords: prostate cancer; castration-resistant prostate cancer; metastatic disease; biomarker; tumor microenvironment; treatment; immunotherapy; drug resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Feature Reviews in Cytokines

edited by

Monika Zajkowska

submission deadline 30 Jan 2026 | 1 articles | Viewed by 570 | Submission Open

Keywords: cytokines; neurodegenerative disease; cancer; diabetes; obesity; immunological disorder; cardiovascular disease; diagnosis; biomarker; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity—2nd Edition

edited by

Adrian-Bogdan Țigu

submission deadline 31 Jan 2026 | 5 articles | Viewed by 11083 | Submission Open

Keywords: cell death; drug repositioning; translational research; oncology; cancer therapy; apoptosis

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Research of Neurodegenerative and Psychiatric Diseases, 2nd Edition

edited by

Dubravka Švob Štrac

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7742 | Submission Open

Keywords: neurodegenerative disorders; psychiatric diseases; biomarkers; therapeutic targets; omics approaches; molecular pathways; cell biology; animal models; clinical studies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Biomarkers in Inflammatory Bowel Disease: Pathophysiology and New Therapeutic Strategies—Second Edition

edited by

Marino Vilović

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6738 | Submission Open

Keywords: inflammatory bowel disease (IBD); Crohn’ s disease; ulcerative colitis; biomarkers; molecular biomarkers in IBD; pathophysiology; therapeutic approaches in IBD; precision medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Nanoparticle-Based Drug Delivery in Cancer Therapy: Current Progress and Challenges

edited by

Menghuan Tang

and

Zhaoqing Cong

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4855 | Submission Open

Keywords: nanoparticle; targeted drug delivery; controlled release; clinical translation; drug resistance; nanomedicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Applications and Perspectives of Cold Electric Discharge Plasmas in Biomedicine and Bioengineering

edited by

Andrei Vasile Nastuta

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4704 | Submission Open

Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Mechanisms and Novel Therapies for Brain Injury: 2nd Edition

edited by

Arjun Sapkota

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4638 | Submission Open

Keywords: stroke; spinal cord injury; traumatic brain injury; seizure; brain tumors; neurodegeneration; neuroinflammation; blood– brain barrier disruption; neuroprotection; drug discover; mechanism of action; target validation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cardiovascular and Metabolic Disease: New Treatment and Future Directions—4th Edition

edited by

Alfredo Caturano

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4605 | Submission Open

Keywords: cardiovascular disease; metabolic disease; diabetes; therapy; drugs; implantable device; heart failure; heart transplantation; cardiac surgery; future directions

(This special issue belongs to the Section Cell Biology and Pathology)

Medicinal Chemistry in Drug Design and Discovery, 2nd Edition

edited by

Małgorzata Jarończyk

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2892 | Submission Open

Keywords: design and synthesis of medicinal compounds; identification and characteristics of targets; mechanism of action; profiles of safety; structure– activity relationship; ligand– target interactions; drugs repurposing

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Therapeutic Potential for Cannabis and Cannabinoids, 3rd Edition

edited by

Wesley M. Raup-Konsavage

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2842 | Submission Open

Keywords: cannabis; tetrahydrocannabinols (THC); cannabidiol (CBD); cannabigerol (CBG); cannabinoid; cannabinol (CBN); cannabichromene (CBC); pain; cancer; anxiety; PTSD; sleep disorders; neuroprotection; anti-inflammatory

(This special issue belongs to the Section Molecular and Translational Medicine)

PPARs in Health and Disease, 2nd Edition

edited by

Maria Konstandi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2743 | Submission Open

Keywords: PPARα ; PPARβ /δ ; PPARγ ; nuclear receptor; lipid homeostasis; glucose homeostasis; neurodegenerative disorders; dyslipidemia; atherosclerosis; cardiovascular disease; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Hypertension and Chronic Renal Failure

edited by

Caterina Carollo

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2716 | Submission Open

Keywords: hypertension; chronic renal failure; NephroCardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Triple Negative Breast Cancer: From Mechanisms to Therapeutic Approaches

edited by Emad Rakha and Padmashree Rida

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2586 | Submission Open

Keywords: triple-negative breast cancer; neoadjuvant; adjuvant; chemotherapy; immunotherapy; antibody– drug conjugates; immune checkpoint inhibitors; DNA damage; EGFR; FGFR; microtubule dynamics; centrosome amplification

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Genetic Research and Molecular Diagnostics for Hematological Diseases

edited by Ying S. Zou and Leonard N. Yenwongfai

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2049 | Submission Open

Keywords: hematological diseases; genetic research; benign hematology; inherited disorders; next-generation sequencing/long-read sequencing; optical genome mapping; transcriptome; proteomics; digital pathology; deep convolutional neural networks

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advances in Combination Therapy for Chronic Diseases: Bridging Conventional and Natural Products for Enhanced Outcomes

edited by

Xian (Phoebe) Zhou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1926 | Submission Open

Keywords: combination therapy; interaction; chronic diseases; synergy; molecular pathways; mathematical methods; minimizing side effects

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Neonatal Medicine in Japan

edited by

Fumihiko Namba

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1599 | Submission Open

Keywords: mesenchymal stromal cells; artificial placenta; therapeutic gasses; animal models; off-label drug use

(This special issue belongs to the Section Molecular and Translational Medicine)

Brain Injury: New Insights into Mechanisms and Future Promising Treatments—Second Edition

edited by

Kristina Pilipović

and

Petra Dolenec

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1596 | Submission Open

Keywords: acquired brain injury; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; stroke; tissue engineering; traumatic brain injury

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Molecular Basis of the Immune Response in Pulmonary Fibrosis

edited by

Tamara Cruz

and

Fernanda Hernandez

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1533 | Submission Open

Keywords: immune response; fibrosis; aging; senescence

(This special issue belongs to the Section Immunology and Immunotherapy)

Feature Reviews in Infection and Immunity

edited by

Vijay Singh Gondil

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1457 | Submission Open

Keywords: emerging pathogens; antimicrobial resistance; vaccine; host-pathogen immune interactions; immunotherapy; antimicrobial drug; immune evasion; innate and adaptive immunity

(This special issue belongs to the Section Immunology and Immunotherapy)

Infectious Diseases: Prevention, Diagnosis, and Treatment Under Antimicrobial Resistance Global Urgency

edited by

Célia F. Rodrigues

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1410 | Submission Open

Keywords: AMR; infectious diseases; bacteria; fungi; alternative treatment

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Therapeutic Strategies in Gynecological Malignant Tumors—2nd Edition

edited by

Alberto Farolfi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1291 | Submission Open

Keywords: targeted therapy; precision medicine; gynecological cancers; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Biology and Oncology)

Ophthalmic Genetics: Unraveling the Genomics of Eye Disorders

edited by Raffaella Cascella

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1164 | Submission Open

Keywords: ophthalmic genetics; inherited retinal disease; genomics; molecular biology; gene therapy; artificial intelligence; bioinformatics; biostatistical analysis

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies

edited by

Deepti Diwan

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1031 | Submission Open

Keywords: neurovascular; blood vessels; nervous system; neurological diseases

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advancements in Cardiac Imaging: Diagnostics, Prognostics, and Therapeutics

edited by Ilaria Dentamaro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 810 | Submission Open

Keywords: cardiac imaging; echocardiography; cardiovascular magnetic resonance imaging; cardio CT; nuclear cardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Exploring Potential Therapeutic Compounds with Anti-Inflammatory Activity

edited by Shomaila Mehmood

submission deadline 31 Jan 2026 | 1 articles | Viewed by 705 | Submission Open

Keywords: green tea polyphenols; isoflavanoids; resveratrol; curcumin; genistein; melatonin; antioxidants; metalloporphyrins; anti-inflammatory compounds

(This special issue belongs to the Section Molecular and Translational Medicine)

Applications and Developments of Metal-Based Drugs

edited by

Sajal Sen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 647 | Submission Open

Keywords: anticancer; anti-infectious diseases; nuclear medicines; immunotherapeutic; drug delivery; organometallic complexes; metal-based drugs; metallotherapeutic drugs

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Advances in Insulin—100 Years Since Its Discovery: 2nd Edition

edited by

Tomislav Bulum

submission deadline 31 Jan 2026 | Viewed by 475 | Submission Open

Keywords: insulin action; insulin analogs; type 1 diabetes; type 2 diabetes; complications; glucose homeostasis

(This special issue belongs to the Section Cell Biology and Pathology)

Feature Reviews in Ophthalmology

edited by

Ana Maria Dascalu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 433 | Submission Open

Keywords: glaucoma; retinal diseases; diabetic retinopathy; age-related macular degeneration; retinitis pigmentosa; Leber's congenital amaurosis; ocular surface pathology

(This special issue belongs to the Section Molecular and Translational Medicine)

Neural Nexus: Interdisciplinary Perspectives on Neurological Disorders

edited by Gianandrea Traversi,

Marianna Mazza

and Giuseppe Marano

submission deadline 31 Jan 2026 | Viewed by 300 | Submission Open

Keywords: neurological disorders; mental health; artificial intelligence; machine learning; biomarkers; drug discovery; therapeutic targets; neuroscience research

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advancements and Challenges in Anticancer Targeted Therapy with Small Molecules

edited by Monika Papiez

submission deadline 31 Jan 2026 | Viewed by 294 | Submission Open

Keywords: small molecules; cancer; anticancer targeted therapy; cancer resistance; cancer growth blockers

(This special issue belongs to the Section Cancer Biology and Oncology)

Nephrotic Syndrome: Pathomechanism, Diagnostics and Novel Treatment Options—2nd Edition

edited by

Kan Katayama

submission deadline 31 Jan 2026 | Viewed by 275 | Submission Open

Keywords: focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Vesicles: Research Advances in Cancer Treatment and Diagnostics

edited by

Luís R. Raposo

submission deadline 31 Jan 2026 | Viewed by 269 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer therapy; diagnostics; cellular communication; tumor microenvironment; EV biogenesis

(This special issue belongs to the Section Cancer Biology and Oncology)

Role of Glycomics in Health and Diseases

edited by

Tijl Vermassen

submission deadline 31 Jan 2026 | Viewed by 269 | Submission Open

Keywords: glycomics; protein chemistry; tumor immunology; biomarker research

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Human Reproductive Biology

edited by

Nikolaos Machairiotis

submission deadline 31 Jan 2026 | 1 articles | Viewed by 245 | Submission Open

Keywords: gametogenesis; fertilization; egg retrieval; embryo implantation; epigenetics; microRNAs in fertility; hormonal signaling; stem cells and fertility; assisted reproductive technologies; molecular and polymorphism in fertility; reproductive health novelty

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Epilepsy Research

edited by Duyu A. Nie

submission deadline 31 Jan 2026 | Viewed by 226 | Submission Open

Keywords: disease mechanisms; genetics; biomarkers; epilepsy surgery; electroencephalogram; animal models; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Research in Neurorehabilitation, 2nd Edition

edited by

Manuel Gaviria

submission deadline 31 Jan 2026 | Viewed by 195 | Submission Open

Keywords: mechanisms; CNS trauma; ischemic CNS injury; neurodegenerative disorders; neurorehabilitation; neuroplasticity; personalized therapy; neuroprosthetics; brain– computer interfaces; neurodevelopmental disorder

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neural Organoids: Advancing Our Understanding of the Central and Peripheral Nervous Systems

edited by Birtele Marcella

submission deadline 31 Jan 2026 | Viewed by 194 | Submission Open

Keywords: neural organoids; brain development; tissue engineering; disease modeling; peripheral nervous system; single-cell analysis; neural circuits; bioengineering; stem cells; neurodevelopmental disorders

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Renin–Angiotensin System in Immune Regulation: Roles in Blood, Vessels, and Inflammation

edited by Chao Liu

submission deadline 31 Jan 2026 | Viewed by 186 | Submission Open

Keywords: renin– angiotensin system; immune regulation; vascular biology; inflammation; T cells; macrophages; neutrophils; angiotensin II; ACE2; stem cells

(This special issue belongs to the Section Immunology and Immunotherapy)

Parkinson’s Disease: Where Are We and Where Are We Going To

edited by Carmen Borrué

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: Parkinson’ s disease; gait disorders; biomarkers; neurodegenerative disease; AI

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Biomarkers and More Efficient Therapies for Sepsis—2nd Edition

edited by

Wen-Lin Su

, Chih-Hao Shen,

Sheng-Kang Chiu

and