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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology

edited by Iyare Izevbaye

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4088 | Submission Open

Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology

(This special issue belongs to the Section Cancer Biology and Oncology)

Feature Reviews on Cardiovascular and Metabolic Diseases

edited by

Cristiana Bustea

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3948 | Submission Open

Keywords: cardiovascular diseases; metabolic diseases; global health; disease prevention; innovative treatments

(This special issue belongs to the Section Cell Biology and Pathology)

Tendinopathy and Myopathy: From Molecular Basis to Therapy

edited by

Simon Fuk-Tan Tang

and Carl Pai Chu Chen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3689 | Submission Open

Keywords: musculoskeletal disorder; tendinopathy; myopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

The Development of Cancer Immunotherapy

edited by

Satoshi Wada

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3554 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

New Insights and Latest Advances in Corneal and Ocular Surface Diseases

edited by Isabella M. Y. Cheung and Akilesh Gokul

submission deadline 30 Nov 2025 | 5 articles | Viewed by 2992 | Submission Open

Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Pulmonary Pathophysiology

edited by Ourania S. Kotsiou and Erasmia Rouka

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2790 | Submission Open

Keywords: pathophysiology; aging; disease; injury; microbiome; small airways; pleura; lung cancer; infections; critical care

(This special issue belongs to the Section Cell Biology and Pathology)

Bioinformatics Analysis of RNA for Human Health and Disease

edited by Jihwan Ha

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2595 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Diagnostics and Therapy for Malignant Tumors: New Developments

edited by

Chan-Yen Kuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2528 | Submission Open

Keywords: metabolites; immunity; microbiome; microenvironment; inflammation

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomarkers for Neurodegenerative Disorders: From Bench to Bedside

edited by George P. Paraskevas

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1293 | Submission Open

Keywords: dementia; Alzheimer’ s disease; frontotemporal dementia; dementia with Lewy bodies; parkinsonism; tau protein; TDP-43; α -synuclein; Tau-PET; amyloid-PET

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Research of Neurological and Psychiatric Disorders

edited by

Yuen Gao

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1155 | Submission Open

Keywords: molecular biology; neurodegenerative disorders; psychiatry; biomarkers; therapeutic targets

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Exploring Human Diseases Through Genomic and Genetic Analyses

edited by Fernando Regateiro and

Henriqueta Silva

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1100 | Submission Open

Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches

edited by

Antonio Biondi

and

Marco Vacante

submission deadline 30 Nov 2025 | 1 articles | Viewed by 992 | Submission Open

Keywords: colorectal cancer; biomarkers; chemotherapy; immunotherapy; liquid biopsy; endoscopy; surgery; microbiota; screening

(This special issue belongs to the Section Cancer Biology and Oncology)

Role of Natural Product in Cardiovascular Disease—2nd Edition

edited by

Jian Li

submission deadline 30 Nov 2025 | 2 articles | Viewed by 764 | Submission Open

Keywords: nature products; phytochemicals; biological and pharmacological activity; cardiovascular disease (CVD) pathogenesis of CVD; risk factors of CVD; metabolic symptom; clinical or preclinical studies

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Neurodevelopmental and Neuropsychiatric Disorders in Animal Models

edited by Yael Abreu-Villaça

submission deadline 30 Nov 2025 | 1 articles | Viewed by 668 | Submission Open

Keywords: mood disorder; mental disorder; substance use disorder; autism spectrum disorder (ASD); attention-deficit/hyperactive disorder (ADHD); depression and anxiety disorders; schizophrenia; bipolar disorder; epilepsy; eating disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches

edited by Yanyun Gao

submission deadline 30 Nov 2025 | Viewed by 513 | Submission Open

Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodegeneration No More: Cutting-Edge Technologies and Therapies in the Evolution of Neurodegenerative Disease Management—2nd Edition

edited by

Masaru Tanaka

Simone Battaglia

and

Donato Liloia

submission deadline 30 Nov 2025 | Viewed by 342 | Submission Open

Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Interplay Between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Mariano Catanesi

submission deadline 30 Nov 2025 | Viewed by 304 | Submission Open

Keywords: miRNA; neurodegenerative diseases; mitochondrial dysfunction; aging; gene expression

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies

edited by

Mubarak Taiwo Mustapha

submission deadline 30 Nov 2025 | Viewed by 289 | Submission Open

Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Mechanisms of Normal and Malignant Hematopoiesis: 2nd Edition

edited by

Myunggon Ko

submission deadline 30 Nov 2025 | Viewed by 281 | Submission Open

Keywords: hematopoietic stem cells; self-renewal; differentiation; hematological malignancies; molecular mechanisms; genetic factors; epigenetic factors; transcriptional regulation; HSC niche; targeted therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Cancer Genetics and Epigenetics

edited by

Zheng-Yuan Su

submission deadline 30 Nov 2025 | Viewed by 199 | Submission Open

Keywords: cancer genetics; epigenetics; DNA methylation; histone modifications; non-coding RNAs; tumor heterogeneity; drug resistance; biomarkers; precision oncology; personalized therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

The Role of Iron in Human Diseases

edited by Margherita Correnti

submission deadline 30 Nov 2025 | 1 articles | Viewed by 186 | Submission Open

Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Diagnosis, Management and Treatment of Rheumatoid Arthritis

edited by Yong Feng

submission deadline 30 Nov 2025 | Viewed by 160 | Submission Open

Keywords: rheumatoid arthritis; autoimmune disorder; synovial inflammation; genetic factors; signaling pathway; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Hepatocellular Carcinoma: From Pathophysiology to Therapeutic Approaches Treatment

edited by

Wasim A. Dar

submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open

Keywords: hepatocellular carcinoma; pathophysiology; therapeutic interventions

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of HOX Genes in Particular Cancers

edited by

Renata Freitas

submission deadline 30 Nov 2025 | Viewed by 137 | Submission Open

Keywords: HOX genes; anti-cancer drugs; cell memory program; epigenetic regulation

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovative Biomaterials and Advanced Techniques for Bone Regeneration Applications

edited by

Antonio Apicella

submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open

Keywords: biomaterials; bone regeneration; osteointegration; 3D printing; biomimetic design

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy

edited by

Andrey Jorge Serra

, Ednei Luiz Antonio, Gianna Móes de Albuquerque-Pontes and Luis Felipe Neves dos Santos

submission deadline 30 Nov 2025 | Viewed by 93 | Submission Open

Keywords: cardiomyopathy; cardiac remodeling; heart disease; heart failure; mechanisms; new therapies; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches

edited by

Guangtong Deng

submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open

Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis

(This special issue belongs to the Section Molecular and Translational Medicine)

Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Second Edition

edited by

Cristina Tudoran

and Dragos Cozma

submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open

Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; thyroid dysfunction; hormonal alterations; endothelial dysfunction; coronary artery disease; hypertension; peripheric arterial disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome

edited by Hermann L. Müller

submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open

Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular and Histopathological Background of Diabetic Neuropathy

edited by

Mária Bagyánszki

submission deadline 30 Nov 2025 | Viewed by 73 | Submission Open

Keywords: diabetic neuropathy; insulin; hyperglycaemia; peripheral neuropathy; autonomic neuropathy; proximal neuropathy; enteric neuropathy; mononeuropathy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Coronary Artery Disease: From Pathophysiology to Therapeutic Strategies

edited by

Pawel Nadziakiewicz

submission deadline 30 Nov 2025 | Viewed by 71 | Submission Open

Keywords: pathophysiological concept of coronary artery disease; coronary microvascular dysfunction; chronic coronary syndrome; acute coronary syndrome; post-acute coronary syndrome with heart failure; diagnostics in coronary artery disease; therapeutic strategies in CAD; revascularization

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Genomics and Bioinformatics of Human Disease

edited by Sankarasubramanian Jagadesan

submission deadline 30 Nov 2025 | Viewed by 64 | Submission Open

Keywords: genomics; bioinformatics; precision medicine; single-cell RNA sequencing; genetic variations; cellular heterogeneity; AI/ML; pathogenicity prediction

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance

edited by

Yinghao Cao

submission deadline 30 Nov 2025 | Viewed by 57 | Submission Open

Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Novel Biomaterials and Tissue Engineering Approaches in Periodontal Regeneration

edited by

Federico Mussano

submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open

Keywords: periodontium; tissue engineering; regenerative medicine; biomaterials; bioprinting; mesenchymal stem/stromal cells; senescence; aging; advanced therapeutics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Therapeutic Resistance in Oral Cancer: Mechanisms, Biomarkers, and Novel Strategies to Restore Treatment Responses

edited by

Vui King Vincent-Chong

submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open

Keywords: oral cancer; OSCC; chemotherapy; radiotherapy; immunotherapy; therapeutic resistance; HNSCC; biomarker; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Neurophysiology and the Treatment of Parkinson’s Disease

edited by

Giorgia Sciacca

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: movement disorders; hypokinetic movement disorders; Parkinson’ s disease; levodopa; treatment; neurophysiology; neuroplasticity; motor learning

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights in Radiotherapy: Bridging Radiobiology and Oncology

edited by

Yuan-Hao Lee

and I-Tsang Chiang

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: tissue-sparing effect; bystander effect; factors that affect radiation-induced lethality; radiation-induced abscopal effect; mechanisms that enhance tissue radiosensitivity; synergistic effect from radiotherapy and immunotherapy; regulatory perspectives on medical radiation safety

(This special issue belongs to the Section Cancer Biology and Oncology)

State-of-the-Art Endocrine Cancer Biology and Oncology

edited by

Piotr Glinicki

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: thyroid and parathyroid tumors; adrenal tumors (hormonally active and inactive; ACC); neuroendocrine tumors (NEN); pituitary neuroendocrine tumors (PiNETs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Urogenital Cancers: New Molecular and Translational Aspects on Carcinogenesis and Treatments (2nd Edition)

edited by

Silvia Di Agostino

Vittoria Rago

and

Anna Perri

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: prostate cancer; bladder cancer; renal cell carcinoma; testicular cancer; ovarian cancer; endometrial cancer; carcinogenesis; biomarkers; early diagnosis; upper urinary tract tumors; diagnosis; treatment; environmental factors; diet

(This special issue belongs to the Section Cancer Biology and Oncology)

Periodontal Disease and Periodontal Tissue Regeneration—Second Edition

edited by

Irina-Georgeta Sufaru

and

Sorina Mihaela Solomon

submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open

Keywords: periodontal diagnosis; periodontal immunology; periodontal microbiology; periodontal tissue regeneration; tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Clinical Advances in Hepatocellular Carcinoma

edited by Mohamed A. Abd El Aziz

submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open

Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation

(This special issue belongs to the Section Cancer Biology and Oncology)

Structure-Based Drug Molecule Design and Organic Synthesis

edited by

Sateesh Dubbu

submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open

Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Engineering Extracellular Matrix (ECM)-Based Scaffold Biomaterials for Cancer Treatment

edited by

Sanjay Pal

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: extracellular matrix; biomaterials; immunomodulatory agents; cancer immunotherapy; sustained delivery; drug delivery; tumor modeling; 3D model; therapeutic response; decellularized ECM

(This special issue belongs to the Section Gene and Cell Therapy)

Inflammatory Bowel Diseases: New Diagnostic and Therapeutic Approaches—Second Edition

edited by

Maria Manuela Estevinho

and

Fernando Magro

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: bowel inflammation; Crohn’ s disease; endoscopy; inflammatory bowel disease; targeted therapy; ulcerative colitis

(This special issue belongs to the Section Immunology and Immunotherapy)

The Preparation of an Exosome/Liposomal Nano-Drug Delivery System and Its Application in the Treatment of Inflammatory Bowel Disease

edited by

Dingpei Long

and

Jialing Bao

submission deadline 30 Nov 2025 | Viewed by 40 | Submission Open

Keywords: exosomes; liposomes; nano-drug delivery systems; inflammatory bowel disease (IBD); targeted therapy; mucosal drug delivery; drug encapsulation; immunomodulation; nanomedicine; extracellular vesicles; personalized medicine

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Pathogenesis, Diagnosis, and Treatment of Prostate Cancer

edited by

Sara Harsini

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: prostate cancer ; molecular imaging; PET/CT; PSMA (prostate-specific membrane antigen); theranostics; radiopharmaceutical therapy; diagnosis and staging; radiology; targeted therapy; tumor microenvironment

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Molecular Research on Physical Activity, Sleep and Cognitive Function

edited by

Yanwei You

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: physical activity; sleep; cognitive function; molecular mechanisms; neuroplasticity; oxidative stress; inflammation; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Small Intestinal Bacterial Overgrowth and Antimicrobial

edited by

Andrej Belančić

and

Mislav Radić

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome

(This special issue belongs to the Section Molecular and Translational Medicine)

Two Decades of Advances in Colorectal Cancer Prevention and Treatment: From Aspirin to Precision Oncology

edited by

Manish Tripathi

and

Puneet Vij

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: immunotherapy; biomarkers; colorectal cancer; targeted therapies; molecular pathways

(This special issue belongs to the Section Cancer Biology and Oncology)

Animal Models for Neurological Disease Research

edited by

Sreeja Sarasamma

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Displaying special issue 551-600 on page 12 of 15.

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