Advanced Research in Melanoma Metastasis

Dear Colleagues,

Metastatic disease remains the leading cause of mortality in melanoma patients. The mechanisms of melanoma progression, invasion, and metastasis formation have been the focus of extensive studies for decades, as melanoma has been observed as having one of the highest metastatic potentials among human cancers. The metastasis formation of primary tumors is a balance of cellular interactions between the host (‘soil’) and the tumor (‘seed’), characterized by altered crosstalk between cells, a mechanism determined by both the intrinsic properties of the tumor cells and the host response. According to the ‘seed and soil’ hypothesis, the primary tumor contributes to the preparation of secondary sites for tumor cell invasion and development, known as the pre-metastatic niche (PMN). The distribution of the targeted organ is especially variable depending on the type of cancer; however, melanoma has the unique property of having a fully comprehensive metastatic potential; hence, any organ or tissue can host melanoma metastasis. The site of distant metastasis is an important and independent predictor of the survival of melanoma patients with metastatic disease.

This Special Issue focuses on experimental insights into melanoma progression, invasion, and metastasis formation, with particular attention to tumor–host interactions, the pre-metastatic niche, and organ-specific metastatic patterns. We welcome laboratory medicine and experimental studies that advance the mechanistic understanding of melanoma dissemination and may reveal new therapeutic targets. Purely clinical studies will not be considered.

Dr. Viktória Koroknai
Guest Editor

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