Role of DNA Methylation in Human Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 2560
Editor
Interests: DNA methylation; nucleosome complexes; chromatin remodeling; chromatin-associated protein complexes
Special Issue Information
Dear Colleagues,
DNA methylation is a fundamental epigenetic mechanism that regulates gene expression, maintains genomic stability, and shapes chromatin organization, thereby influencing cell fate across development and disease. This Special Issue, "Role of DNA Methylation in Human Health and Diseases", aims to compile high-quality research articles and reviews that advance our understanding of the dynamic mechanisms of DNA methylation in both physiological and pathological contexts. We seek to highlight studies that investigate the roles of DNA methylation in development, aging, cancer, neurological disorders, metabolic diseases, and immune responses.
Particular emphasis will be placed on mechanistic and translational insights, including the discovery of methylation-based biomarkers for early diagnosis and prognosis, as well as the development of novel epigenetic therapies. We especially welcome submissions that utilize cutting-edge technologies—such as structural biology, single-cell and multi-omics, and integrative computational approaches—to map methylation patterns, uncover regulatory mechanisms, and explore the therapeutic potential of modulating the epigenome.
This Special Issue seeks to highlight the principles of DNA methylation in human biology and foster innovative avenues for precision epigenetic interventions. We aim to provide a valuable resource for researchers bridging basic epigenetic mechanisms with translational applications, advancing precision medicine and improving patient outcomes.
Dr. Ting-Hai Xu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA methylation
- epigenetics
- translational research
- biomarker
- gene regulation
- epigenetic therapy
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